Preparation of absorbable surgical suture: Novel approach in biomedical application

Senthil, R.; Parvathaleswara, Sastry Thotapalli; Nandhagobal, Gunadharini; Alagumuthu, Tamilselvi; Nallathambi, Gobi

doi:10.1016/j.jddst.2018.08.010

Cited by 22 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[43] Rethinam et al ( 2018) prepared absorbable sutures in their studies, and they directly seeded HaCat cells on these absorbable sutures to perform MTT assay, as well. [44] Consistent with the results of studies with different spider species in the literature, it was concluded that the silk material obtained from A. bruennichi spiders, which was designed to be used as a surgical suture, is not cytotoxic on mammalian fibroblast cells and can be evaluated as biocompatible in this respect.…”

Section: Cytotoxicity Testing Of Spider Silksupporting

confidence: 71%

See 1 more Smart Citation

In vitro and in vivo investigation of Argiope bruennichi spider silk‐based novel biomaterial for medical use

Karahisar Turan,

Kılıç Süloğlu,

İde

et al. 2024

Biopolymers

View full text Add to dashboard Cite

As a natural and biocompatible material with high strength and flexibility, spider silk is frequently used in biomedical studies. In this study, the availability of Argiope bruennichi spider silk as a surgical suture material was investigated. The effects of spider silk‐based and commercial sutures, with and without Aloe vera coating, on wound healing were evaluated by a rat dorsal skin flap model, postoperatively (7th and 14th days). Biochemical, hematological, histological, immunohistochemical, small angle x‐ray scattering (SAXS) analyses and mechanical tests were performed. A. bruennichi silk did not show any cytotoxic effect on the L929 cell line according to MTT and LDH assays, in vitro. The silk materials did not cause any allergic reaction, infection, or systemic effect in rats according to hematological and biochemical analyses. A. bruennichi spider silk group showed a similar healing response to commercial sutures. SAXS analysis showed that the 14th‐day applications of A. bruennichi spider silk and A. vera coated commercial suture groups have comparable structural results with control group. In conclusion, A. bruennichi spider silk is biocompatible in line with the parameters examined and shows a healing response similar to the commercial sutures commonly used in the skin.

show abstract

Section: Cytotoxicity Testing Of Spider Silksupporting

confidence: 71%

“…[ 43 ] Rethinam et al (2018) prepared absorbable sutures in their studies, and they directly seeded HaCat cells on these absorbable sutures to perform MTT assay, as well. [ 44 ]…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo investigation of Argiope bruennichi spider silk‐based novel biomaterial for medical use

Karahisar Turan,

Kılıç Süloğlu,

İde

et al. 2024

Biopolymers

View full text Add to dashboard Cite

show abstract

“…Among those of a synthetic origin, are glycolic polyacid (Dexon), nylon (Ethilon™), polydioxanone (PDS II™), polyglactin 910 (Vicryl™), polypropylene (Prolene™) [10], and those from a natural origin are of catgut (collagen derived from intestinal submucosa from sheep), silk (from the silkworm Bombyx mori L.), cotton, and flax. In this sense, studies aiming to develop suture materials from natural biopolymers, such as collagen [11], chitin [12], and chitosan [13], have been conducted. Chitosan is a polymer derived from chitin, which has been found in a wide range of natural sources (the exoskeletons of the crustaceans, crabs, and shrimps, and the cell walls of fungi [14]) that exhibit biodegradability, biocompatibility, and hemostatic capacity, as well as the ability to inhibit the growth of microorganisms and accelerate the capacity of wound healing [15,16,17,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Silva

Cruz

et al. 2019

Materials

View full text Add to dashboard Cite

The aim of this study was to prepare chitosan (CS) filaments incorporated with N-acetyl-D-Glucosamine (GlcNAc), using the wet spinning method, in order to combine the GlcNAc pharmacological properties with the CS biological properties for use as absorbable suture materials. The filaments were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), uniaxial tensile testing, in vitro biodegradation, and through in vitro drug release and cytotoxicity studies. It was observed that the addition of GlcNAc did not alter the morphology of the filaments. The CS and CS/GlcNAc filaments presented diameters 145 µm and 148 µm, respectively, and the surfaces were homogeneous. Although the mechanical resistance of the chitosan filaments decreased with the incorporation of the GlcNAc drug, this property was greater than the mean values indicated in the U.S. Pharmacopeia (1.7 N) for suture number 6-0 (filament diameter of 100–149 μm). The biodegradation of the CS filaments was accelerated by the addition of GlcNAc. After 35 days, the CS/GlcNAc filaments degradability was at its total, and for the CS filaments it was acquired in 49 days. The in vitro kinetic of the release process was of the zero-order and Hopfenberg models, controlled by both diffusion and erosion process. The in vitro cytotoxicity data of the CS and CS/GlcNAc filaments toward L929 cells showed that these filaments are nontoxic to these cells. Thus, the GlcNAc-loaded CS filaments might be promising as absorbable suture materials. In addition, this medical device may be able to enhance healing processes, relieve pain, and minimize infection at the surgery site due the prolonged release of GlcNAc.

show abstract

“…In fact, collagen absorbable sutures are mechanically robust and demonstrate more minor tissue reactivity than standard silk sutures and absorbable sutures [32]. Suture materials are used to bring body tissues together until healing takes place [33]. Nonetheless, grafting absorbable collagen sutures onto the human body internally could trigger acute inflammation and breed bacteria around the wounds.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Surgical Sutures Developed Using Electrostatic Yarn Wrapping Technology

Lou

Hung

Wei

et al. 2023

JFB

View full text Add to dashboard Cite

A significant amount of research has been conducted on applying functional materials as surgical sutures. Therefore, research on how to solve the shortcomings of surgical sutures through available materials has been given increasing attention. In this study, hydroxypropyl cellulose (HPC)/PVP/zinc acetate nanofibers were coated on absorbable collagen sutures using an electrostatic yarn winding technique. The metal disk of an electrostatic yarn spinning machine gathers nanofibers between two needles with positive and negative charges. By adjusting the positive and negative voltage, the liquid in the spinneret is stretched into fibers. The selected materials are toxicity free and have high biocompatibility. Test results indicate that the nanofiber membrane comprises evenly formed nanofibers despite the presence of zinc acetate. In addition, zinc acetate can effectively kill 99.9% of E. coli and S. aureus. Cell assay results indicate that HPC/PVP/Zn nanofiber membranes are not toxic; moreover, they improve cell adhesion, suggesting that the absorbable collagen surgical suture is profoundly wrapped in a nanofiber membrane that exerts antibacterial efficacy and reduces inflammation, thus providing a suitable environment for cell growth. The employment of electrostatic yarn wrapping technology is proven effective in providing surgical sutures with antibacterial efficacy and a more flexible range of functions.

show abstract

Preparation of absorbable surgical suture: Novel approach in biomedical application

Cited by 22 publications

References 26 publications

In vitro and in vivo investigation of Argiope bruennichi spider silk‐based novel biomaterial for medical use

In vitro and in vivo investigation of Argiope bruennichi spider silk‐based novel biomaterial for medical use

N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Antibacterial Surgical Sutures Developed Using Electrostatic Yarn Wrapping Technology

Contact Info

Product

Resources

About