Preparation of a porous functional polymer and its application in the separation of small molecules in conjunction with HPLC

Advancements in the preparation of high-performance liquid chromatographic organic polymer monoliths for the separation of small-molecule drugs

“…The other type porogen, in which the monomer is insoluble, results in a smaller pore structure. In recent years, binary and ternary porogens have often been used in the preparation of monolithic organic polymer columns [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] ( Table 3 ).…”

“… Type of monoliths Monolithic column Porogen Ref. Poly(styrene- co -divinylbenzene) Water, methanol, ethanol [30] 1-propanol, formamide [31] Toluene, isooctane [32] Toluene, isooctane methacrylic acid(micro-porogen) [32] Polymethacrylate-based monoliths Poly(BMA-EDMA) 1-propanol, 1,4-butanediol, water [33] Poly(SMA-co-2-Me-1,8-ODDMA) Tert.-butanol, 1,4-butanediol [34] Poly(BMA-co-EDMA) 1-propanol, 1,4-butanediol, water [35] Poly(BMA-co-META-co-EDMA) Water, 1,4-butanediol, 1-propanol [36] Poly(1,12-DoDDMA) Methanol, dodecanol [22] Poly (VER-co-EDMA) n -butanol, 1,4-butanediol, water [26] Poly (SPP- PETA) Ethanol, ethylene glycol [37] Poly(HDDA-co-BMA-co-EDMA) Dodecyl alcohol [38] Poly(TAIC -TMPTA) Polyethylene glycol 200, 1,2-propanediol [39] Polymers Glycerol dimethacrylate Polystyrene, chlorobenzene [40] Poly(ethylene glycol methyl ether acrylate-co-polyethylene glycol diacrylate) Ethyl ether, poly(ethyleneoxide)-poly(propylene oxide)-poly(ethylene oxide) [41] Note: butylmethacrylate (BMA), ethylenedimethacrylate (EDMA), stearyl methacrylate (SMA), 2-methyl-1,8-octanediol dimethacrylate (2-Me-1,8-ODDMA), [2-(methacryloyloxy)ethyl]-trimethyl ammonium chloride (META), 1,12-dodecanediol dimethacrylate (1,12-DoDDMA), vinyl ester resin(VER), triallyl isocyanurate (TAIC) -trimethylolpropane triacrylate (TMPTA), {[3-(methacryloylamino) propyl] dimethyl(3-sulf...…”

“…In 2014, Li et al [38] used hexanediol dimethacrylate (HDDA) and butylmethacrylate (BMA) as monomers, EDMA as a crosslinking agent, and dodecyl alcohol as a porogen to prepare a polymer monolith with good permeability, high mechanical stability and a large surface area. Benzene, amines, and phenols were successfully separated on the prepared monolithic column.…”

Poly (styrene-divinyl benzene-glycidylmethacrylate) stationary phase grafted with poly amidoamine (PAMAM) dendrimers for rapid determination of phenylene diamine isomers in HPLC

“…However, silica columns always have short service life in base mobile phase and high temperature, which limits the serviceable range of the columns [23,24]. To improve chemical and thermal stabilities, organic polymer supports have been developed as HPLC stationary phase [25,26]. Organic polymers used for HPLC matrices are mainly synthesized from styrene, divinyl benzene, methacrylate, acrylates and acrylamide monomers [27][28][29].…”

Preparation of a porous polymer monolithic column with an ionic liquid as a porogen and its applications for the separation of small molecules in high performance liquid chromatography

“…[1][2][3] Monoliths can be categorized into organic polymer-based and inorganic silica-based monoliths depending on the nature of the precursors used. [7][8][9] Although typical polymer monoliths are successfully used in the separation of macromolecules, efficient separation of small molecules is difficult to achieve. 5,6 There are increasing reports concerning polymer monoliths employed as the stationary phases because they possess unique structures.…”