Preparation of a novel chitosan-microcapsules/starch blend film and the study of its drug-release mechanism

Huo, Weiqiang; Xie, Gancheng; Zhang, Weixin; Wang, Wei; Shan, Junyang; Liu, Hechou; Zhou, Xiaohua

doi:10.1016/j.ijbiomac.2016.02.049

Cited by 45 publications

(15 citation statements)

References 22 publications

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“…The release rates in vitro of Chitosan (CS)-microcapsules (MCs) and Antofloxacin-loaded CS-MCs and starch (AMS) films prepared by Weiqiang Huo and Gancheng Xie were 70% and 15%. The release rates in vitro after 20 h were 95% and 30%, after 5 h were 52% and 8% respectively [45]. For microcapsules, excessively long release times and excessive release rates are detrimental, especially drugs or supplements, time of digestion and absorption of the human body does not exceed 6 h, the small intestine is the most important place of absorption, so the drug encapsulated in the microcapsules to release in a large amount at specific time.…”

Section: Resultsmentioning

confidence: 99%

Microencapsulation of Phosphorylated Human-Like Collagen-Calcium Chelates for Controlled Delivery and Improved Bioavailability

Liu

Deng

et al. 2018

Polymers

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Abstract:The bioavailability of Phosphorylated Human-like Collagen-calcium chelates (PHLC-Ca) as calcium supplement is influenced by the extremely low pH and proteolytic enzymes in the gastrointestinal tract. This study addresses these issues by microencapsulation technology using alginate (ALG) and chitosan (CS) as wall materials. The different ratio of ALG to PHLC-Ca on microcapsules encapsulation efficiency (EE) and loading capacity (LC) was evaluated and 1:1/2 was selected as the optimal proportion. The microcapsules were micron-sized and spherical in shape. PHLC-Ca was successfully entrapped into the matrix of ALG through forming intermolecular hydrogen bonding or other interactions. The confocal laser scanning microscopy (CLSM) indicated that CS was coated on ALG microspheres. The MTT assay exhibited that CS/ALG-(PHLC-Ca) microcapsules extracts were safe to L929. The animal experiment showed that CS/ALG-(PHLC-Ca) microcapsules was superior to treating osteoporosis than PHLC-Ca. These results illustrated that the bioavailability of PHLC-Ca was improved by microencapsulated.

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Section: Resultsmentioning

confidence: 99%

Microencapsulation of Phosphorylated Human-Like Collagen-Calcium Chelates for Controlled Delivery and Improved Bioavailability

Liu

Deng

et al. 2018

Polymers

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“…The increase in size could be due to chemical structure and concentrations of the solutions used for encapsulation of probiotics. Characterization of microbeads was done in a study [32] who reported that the spheres shape microbeads are easier to produce and use. Ashwar et al [24] reported in a study that the smooth and spherical hydrogel beads formed while dropping the alginate alone and alginate with various concentrations of soy protein isolate (SPI).…”

Section: Characterization Of Beadsmentioning

confidence: 99%

Survival and stability of free and encapsulated probiotic bacteria under simulated gastrointestinal and thermal conditions

Afzaal

Saeed

et al. 2020

International Journal of Food Properties

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The core objective of the current study was to assess the effect of encapsulation on the viability and stability of probiotic bacteria under simulated gastrointestinal digestion and thermal conditions. Purposely, probiotics were encapsulated with hydrogel matrices (sodium alginate and carrageenan) using encapsulator. Furthermore, developed microbeads were characterized by X-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopy to elucidate the interaction between hydrogel matrices and probiotics. The viability of probiotics assessed by subjecting to simulated GIT and thermal conditions. Encapsulation exhibited a significant (p< .05) effect on the survival and stability of probiotics. Overall, a decreasing trend in viability of probiotics was observed in all treatments. A rapid log reduction was observed when free probiotic cells were stored at refrigeration temperature compared to encapsulated probiotic bacteria. Likewise, in vitro gastrointestinal assay, only 3 log while in case of non-encapsulated bacteria 6 log reduction was recorded. In short, the results of the viable count in the case of encapsulated cells were above recommended level (10 6 cfu/g) under thermal as well as in GIT conditions.

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“…Антибиотик антофлоксацин (antofloxacin) был испытан в качестве модели при изучении кинетики высвобождения лекарственного вещества. Было установлено, что с увеличением содержания хитозана понижается коэффициент диффузии лекарства и растворимость пленки в воде [188].…”

Section: пальмовое маслоunclassified

Edible polymer films and coatings: background and current state (a review)

Savitskaya¹

2016

polymmattech

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В обзоре представлены данные о составе, способах получения и областях применения съедобных полимерных пленок и покрытий в качестве полностью биоразлагаемых упаковочных материалов. Проанализированы их основные физико-химические характеристики, функции и назначение, приведены примеры коммерциализации разработок в этой области. Savitskaya T. A. Edible polymer films and coatings: background and current state (a review). This review summarizes the composition, methods of preparation and applications of edible polymer films and coatings as completely biodegradable packaging materials. Basic physical and chemical characteristics, functions and purposes have been analyzed.The examples of the commercialization of research in this area are given.

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Preparation of a novel chitosan-microcapsules/starch blend film and the study of its drug-release mechanism

Cited by 45 publications

References 22 publications

Microencapsulation of Phosphorylated Human-Like Collagen-Calcium Chelates for Controlled Delivery and Improved Bioavailability

Microencapsulation of Phosphorylated Human-Like Collagen-Calcium Chelates for Controlled Delivery and Improved Bioavailability

Survival and stability of free and encapsulated probiotic bacteria under simulated gastrointestinal and thermal conditions

Edible polymer films and coatings: background and current state (a review)

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