Preparation of a new nerve guide from a poly(l-lactide-co-6-caprolactone)

Perego, G.; Cella, Gian Domenico; Aldini, NicolòNicoli; Fini, Milena; Giardino, Roberto

doi:10.1016/0142-9612(94)90066-3

Cited by 73 publications

(36 citation statements)

References 12 publications

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“…26 Biodegradable nerve guides potentially provide a successful alternative. 1,27,28 The objective of using biodegradable p(DLLA-⑀-CL) nerve guides is that the nerve guide degrades after guiding the regenerating nerve fibres towards the distal nerve stump. This generally prevents the formation of a neuroma-in-continuity and ingrowth of fibrous tissue.…”

Section: Discussionmentioning

confidence: 99%

Functional assessment of sciatic nerve reconstruction: Biodegradable poly (DLLA-?-CL) nerve guides versus autologous nerve grafts

Meek¹,

Dijkstra²,

Dunnen³

et al. 1999

Microsurgery

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The aim of this study was to compare functional nerve recovery after reconstruction with a biodegradable p(DLLA-epsilon-CL) nerve guide filled with modified denatured muscle tissue (MDMT), or an autologous nerve graft. We evaluated nerve recovery using walking track analysis (measurement of the sciatic function index [SFI]) and electrostimulation tests. Functional nerve recovery after reconstruction with a biodegradable p(DLLA-epsilon-CL) nerve guide filled with MDMT was faster when compared with nerve reconstruction using an autologous nerve graft. We conclude that in case of a short nerve gap in the rat, reconstruction can best be carried out using a p(DLLA-epsilon-CL) biodegradable nerve guide filled with MDMT.

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Section: Discussionmentioning

confidence: 99%

Functional assessment of sciatic nerve reconstruction: Biodegradable poly (DLLA-?-CL) nerve guides versus autologous nerve grafts

Meek¹,

Dijkstra²,

Dunnen³

et al. 1999

Microsurgery

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“…For example, some models of nerve regeneration use a tubular prosthesis able to guide axonal outgrowth. [2][3][4][5] The in vitro reconstitution of orientated systems as neuronal networks also needs cell culture substrates capable of directing the growth of neurons and their processes. 6,7 These surfaces can be used to study neuronal electrical activities 8 or intracellular ionic flow.…”

Section: Introductionmentioning

confidence: 99%

Fibronectin-pluronic coadsorption on a polystyrene surface with increasing hydrophobicity: Relationship to cell adhesion

Detrait

Lhoest

Bertrand

et al. 1999

J. Biomed. Mater. Res.

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Recently, patterned polystyrene surfaces containing hydrophobic (PS) and more hydrophilic (PSox) areas have been shown to be capable of directing cellular growth, which is mainly due to the competitive adsorption of adhesive and antiadhesive molecules. In this article, the competitive adsorption between a pluronic surfactant and fibronectin was studied on homogeneous PS or PSox substrates conditioned with mixtures containing increasing concentrations of one of the two molecules. Radiolabeling and X-ray photoelectron spectroscopy techniques showed that fibronectin adsorption increased on both surfaces if the fibronectin concentrations increased in the conditioning mixture. In contrast, fibronectin adsorption decreased on PSox and did not occur on PS surfaces when pluronic concentrations increased in the coating mixture. A comparison of these data with pheochromocytoma and Schwann cells cultured on patterned surfaces showed that the direction of cell growth on PSox areas depended first on the relative concentrations of the two components in the mixtures, and second, on their ratio; the best concentration ratio probably depends on the cell's ability to recondition its support.

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“…One successful alternative to eliminate these problems is the use of biodegradable nerve guides. [1][2][3] After functioning as a temporary scaffold for nerve regeneration, they gradually degrade. The use of a biodegradable nerve guide composed of an amorphous copolymer of DL-lactide and -caprolactone [p(DLLA--CL)] has proven to be effective.…”

mentioning

confidence: 99%

Long-term evaluation of functional nerve recovery after reconstruction with a thin-walled biodegradable poly (DL-Lactide-?-caprolactone) nerve guide, using walking track analysis and electrostimulation tests

Meek¹,

Dunnen

Schakenraad³

et al. 1999

Microsurgery

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This study was performed to evaluate the long-term functional nerve recovery after reconstruction of a 10-mm gap in the sciatic nerve of the rat, with a thin-walled nerve guide, composed of a biodegradable copolymer of DL-lactide and epsilon-caprolactone [p(DLLA-epsilon-CL)]. To evaluate both motor and sensory nerve recovery, walking track analysis and electrostimulation tests were carried out after implantation periods ranging from 3 to 52 weeks postoperatively. The first signs of both motor and sensory nerve recovery could be observed after 5 weeks. After 15 weeks, 70% of the sciatic function and 90% of the sensory nerve function had been recovered. After this period, the sciatic function index (SFI) did not improve further, whereas the sensory nerve function appeared to return to normal. When the results of the SFI measurements, minus those obtained from rats with severe automutilation, are extrapolated, further improvement of the SFI might be expected after 52 weeks. The fact that 100% sensory nerve recovery was obtained, as measured by the electrostimulation test, could be explained by sensory reinnervation from surrounding areas. The SFI was not fully reestablished because automutilation had a great impact on the use of walking track assessment.

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Preparation of a new nerve guide from a poly(l-lactide-co-6-caprolactone)

Cited by 73 publications

References 12 publications

Functional assessment of sciatic nerve reconstruction: Biodegradable poly (DLLA-?-CL) nerve guides versus autologous nerve grafts

Functional assessment of sciatic nerve reconstruction: Biodegradable poly (DLLA-?-CL) nerve guides versus autologous nerve grafts

Fibronectin-pluronic coadsorption on a polystyrene surface with increasing hydrophobicity: Relationship to cell adhesion

Long-term evaluation of functional nerve recovery after reconstruction with a thin-walled biodegradable poly (DL-Lactide-?-caprolactone) nerve guide, using walking track analysis and electrostimulation tests

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