Preparation of a diclofenac potentiometric sensor and its application to pharmaceutical analysis and to drug recovery from biological fluids

Shamsipur, Mojtaba; Jalali, Fahimeh; Ershad, Sohrab

doi:10.1016/j.jpba.2004.07.051

Cited by 70 publications

(34 citation statements)

References 19 publications

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“…They include potentiometry [2][3][4], chromatography [1,5], fluorometry [6][7][8], gravimetric [9], spectrophotometric [10][11][12][13][14], chemometric [15][16][17] and other methods [18][19][20][21].…”

Section: Fig 1 (A) -Diclofenac (B) -Rhodamine Bmentioning

confidence: 99%

Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B

Kormosh¹,

Hunka²,

Bazeľ

et al. 2007

Open Chemistry

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Abstract:The potentiometric response characteristics of a diclofenac selective electrode, based on ion association in different plasticizers, were compared. The sensitivity, working range, detection limit and selectivity of membrane sensors demonstrated significant dependence on the type of plasticizers. The potentiometric unit presented a linear response toward diclofenac concentrations between 1 × 10 −5 − 5 × 10 −2 mol L −1 , with slopes of approximately 60 mV dec −1 , and exhibited a response time of 3 s.The potentiometric analysis of sodium diclofenac in pharmaceutical formulations was perfomed by the membrane electrode proposed and compared with the results of potentiometric titration given by the Pharmacopoeia of Ukraine.

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Section: Fig 1 (A) -Diclofenac (B) -Rhodamine Bmentioning

confidence: 99%

Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B

Kormosh¹,

Hunka²,

Bazeľ

et al. 2007

Open Chemistry

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“…These include potentiometry (Shamsipur, Jalali, Ershad, 2005;Santini, Pezza, Pezza, 2006;Hassan et al, 2005), capillary zone electrophoresis (Jin, Zhang, 2000), high performance liquid chromatography (HPLC) (González, Yuln, Volonté, 1999;Kasperek, 2008;Arcelloni et al, 2001), highperformance liquid chromatography-mass spectrometry (HPLC-MS) (Abdel-Hamid, Novotny, Hamza, 1990), spectrophotometry (Botello, Perez-Caballero, 1995), spectrofluorometry (Arancibia, Boldrini, Escandar, 2000;Damiani et al, 1999;Carreira et al, 1995), thin layer chromatography (Sun, Fabre, 1994), gas chromatography (Siou, Pommier, Godbillon, 1991;Yilmaz, 2010), polarographic analysis (Xu, Chen, Song, 2004), spectrophotometry (De Souza, Tubino, 2005;AgatonovicKustrin et al, 1997;Matin, Farajzadeh, Joyuban, 2005;Sastry, Prasad-Tipirneni, Suryanarayana, 1989;Sena et al, 2004) and electrochemistry methods (Blanco-Lopez et al, 2003;Goyal, Chatterjee, Agrawal, 2010;Manea et al, 2010). In all electrochemical methods, modified electrodes were used due to the gradual passivation or contamination of unmodified solid working electrodes occurred during the diclofenac oxidation.…”

Section: Introductionmentioning

confidence: 99%

Differential pulse voltammetric determination of diclofenac in pharmaceutical preparations and human serum

Yılmaz

Kaban

Akcay

et al. 2015

Braz. J. Pharm. Sci.

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This article describes a differential pulse voltammetric (DPV) method for the determination of diclofenac in pharmaceutical preparations and human serum. The proposed method was based on electro-oxidation of diclofenac at platinum electrode in 0.1 M TBAClO 4 /acetonitrile solution. The well-defined two oxidation peaks were observed at 0.87 and 1.27 V, respectively. Calibration curves that obtained by using current values measured for second peak were linear over the concentration range of 1.5-17.5 μg mL -1 and 2-20 μg mL -1 in supporting electrolyte and serum, respectively. Precision and accuracy were also checked in all media. Intra-and inter-day precision values for diclofenac were less than 3.87, and accuracy (relative error) was better than 4.12%. The method developed in this study is accurate, precise and can be easily applied to Diclomec, Dicloflam and Voltaren tablets as pharmaceutical preparation. In addition, the proposed technique was successfully applied to spiked human serum samples. No electroactive interferences from the endogenous substances were found in human serum.Uniterms: Diclofenac/determination. Differential pulse voltammetry/quantitative analysis. Pharmaceutical formulations/analysis. Human serum/analysis Este artigo descreve um método de voltametria de pulso diferencial (VPD) para a determinação de diclofenaco em preparações farmacêuticas e em soro humano. O método proposto foi baseado em eletroxidação de diclofenaco no eléctrodo de platina em solução 0,1 M TBAClO 4 /acetonitrila. Dois picos de oxidação bem definidos foram observados em 0,87 e 1,27 V, respectivamente. As curvas de calibração obtidas utilizando-se valores de corrente medidos por segundo pico foram lineares no intervalo de concentração de 1,5-17,5 μg mL -1 e 2-20 μg mL -1 em eletrólito suporte e soro, respectivamente. Precisão e exatidão também foram verificadas em todos os meios. Valores de precisão intra-e inter-dia para o diclofenaco foram inferiores a 3.87 e a precisão (erro relativo) foi melhor do que 4,12%. O método desenvolvido neste estudo é exato, preciso e pode ser facilmente aplicado a Diclomec, Dicloflam e comprimidos Voltaren, como preparação farmacêutica. Além disso, a técnica proposta foi aplicada com sucesso em amostras de soro humano. Não se observaram interferências das substâncias endógenas no soro humano.Unitermos: Diclofenaco/determinação. Voltametria de pulso diferencial/análise quantitativa. Formulações farmacêuticas/análise. Soro humano/análise.

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“…The various analytical methods have been proposed for the determination of EDTA (5-9), sorbic acid (10)(11)(12)(13)(14), and diclofenac sodium (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). To the best of our knowledge, this study is the first report describing simultaneous determination of EDTA, sorbic acid, and diclofenac sodium in pharmaceutical preparations.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of EDTA, Sorbic Acid, and Diclofenac Sodium in Pharmaceutical Preparations Using High-Performance Liquid Chromatography

2013

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Abstract. A simple high-performance liquid chromatographic method for simultaneous determination of ethylenediaminetetraacetic acid (EDTA), sorbic acid, and diclofenac sodium was developed and validated. Separation was achieved on a C 18 column (10 cm×4.6 mm) using gradient elution. The mobile phase consisted of acetonitrile-ammonium dihydrogen phosphate buffer solution (0.01 M, pH02.5, containing 0.8% tetra-n-butyl ammonium hydroxide). The detector wavelength was set at 254 nm. Under these conditions, separation of three compounds was achieved in less than 10 min. The effect of two metal salts and metal concentration on peak area of EDTA was investigated. The pH effect on retention of EDTA and sorbic acid was studied. The method showed linearity for EDTA, sorbic acid, and diclofenac in the ranges of 2.5-100.0, 5.0-200.0, and 20.0-120.0 μg/mL, respectively. The within-and between-day relative standard deviations ranged from 0.52 to 1.94%, 0.50 to 1.34%, and 0.78 to 1.67% for EDTA, sorbic acid, and diclofenac, respectively. The recovery of EDTA, sorbic acid, and diclofenac from pharmaceutical preparation ranged from 96.0-102.0%, 99.7-101.5%, to 97.0-102.5%, respectively. To the best of our knowledge, this is the first report about simultaneous determination of EDTA, sorbic acid, and diclofenac.

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Preparation of a diclofenac potentiometric sensor and its application to pharmaceutical analysis and to drug recovery from biological fluids

Cited by 70 publications

References 19 publications

Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B

Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B

Differential pulse voltammetric determination of diclofenac in pharmaceutical preparations and human serum

Simultaneous Determination of EDTA, Sorbic Acid, and Diclofenac Sodium in Pharmaceutical Preparations Using High-Performance Liquid Chromatography

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