Preparation of 5-Heteroaryl Substituted 1-(4-Fluorophenyl)-1H-indoles via Palladium-Catalyzed Negishi and Stille Cross-Coupling Reactions

Abstract

P r e p a r a t i o n o f 5 -H e t e r o a r y l S u b s t i t u t e d I n d o l e sAbstract: Palladium-catalyzed Negishi cross-coupling of 5-1-(4fluorophenyl)indolylzinc chloride with N-methyl-halopyrazoles, bromopyridines and bromopyrimidines in gram scale gave the corresponding cross-coupled products in 38-85% yield.