Preparation of 5-Alkyl-3-carboxymethylrhodanines and Their Aldose Reductase Inhibitory Activity.

Rhodanine derivatives as inhibitors of JSP-1

“…7 In contrast to literature reports, efforts to reduce 11 with sodium borohydride in DMF at 0°C failed to produce any of the desired product. 8 ammonium acetate provided the corresponding alkene in a 1:10 ratio of geometrical isomers by 1 H NMR. Based on literature precedence the isomeric ratio was presumed to be mainly the Z stereoisomer.…”