Synthesis of pyridazine acetic acid derivatives possessing aldose reductase inhibitory activity and antioxidant properties

Studies on Some 3(2H)-Pyridazinone Derivatives with Antinociceptive Activity

“…Nineteen new [6-(4-methoxyphenyl)-3(2H)-pyridazinone-2-yl]-acetamide (1-10) and 3-[6-(4-methoxyphenyl)-3(2H)-pyridazinone-2-yl]propanamide (11)(12)(13)(14)(15)(16)(17)(18)(19) derivatives have been synthesized in this study. The structures of the compounds have been elucidated by their IR and NMR spectral data and elemental analysis.…”

“…In addition, various compounds incorporating a 3(2H)-pyridazinone ring have been synthesized and their pharmacological activities have been reported [10][11][12] . Recently it was reported that a considerable number of 3(2H)-pyridazinone derivatives have analgesic activity [6,[13][14][15][16][17][18] .…”

Versatility of the pyridazine system: Chemistry and biology

“…Though definitely less potent than epibatidine, which is active in the same test at 1 µg/kg, 1a favourably compared with morphine, active at 2 mg/kg. In addition, 1a exhibited the highest ratio (30) between the maximal non-toxic dose and the minimal analgesic dose, when compared to morphine (10) and epibatidine (7). It should be noted that reversion of the chloropyridazine substituent from N 3 to N 8 as in 2a, or the insertion on N 8 of an alkyl (1c) or a propionyl group (1b), markedly reduced or -as for 1b -abolished the activity.…”

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“…For this purpose, various compounds incorporating a pyridazinone ring have been synthesized and their pharmacological activities have been reported 1,2 . It has been reported that a considerable number of 3(2H)-pyridazinone derivatives bear analgesic activity.…”