Preparation, characterization, in vivo and in vitro studies of arsenic trioxide Mg-Fe ferrite magnetic nanoparticles

Yang, Guosheng; Li, Xianghui; Zhao, Zhe; Wang, Wenbo

doi:10.1038/aps.2009.158

Cited by 19 publications

(9 citation statements)

References 17 publications

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“…The variation of cell viabilities with respect to MgFe 2 O 4 concentration is shown in Figure 6. This variation is also supported by the previous experimental results in which the magnesium nanoparticle shows toxicity at only higher concentrations [33,55].…”

Section: Cytotoxicity and Induction Of Apoptosis By Mgfe 2 Osupporting

confidence: 87%

Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure

Kanagesan

Hashim

Subramani

et al. 2013

Journal of Nanomaterials

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Nanocrystalline magnesium ferrites (MgFe2O4) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2O4nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μg/mL) against MCF-7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe2O4nanoparticles in a dose-dependent manner. Flow cytometry analysis shows that MgFe2O4nanoparticles in 800 μg/mL concentration are more cytotoxic compared to vehicle-treated MCF-7 cells and suggests their potential utility as a drug carrier in the treatment of cancer.

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Section: Cytotoxicity and Induction Of Apoptosis By Mgfe 2 Osupporting

confidence: 87%

Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure

Kanagesan

Hashim

Subramani

et al. 2013

Journal of Nanomaterials

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“…The encapsulated microcrystal did not grow to large crystal but was stabilized within microsphere for sustained release (Figure 2(A,D)). The drug load was over 40%, which is 5-6 folds higher than that of reported ATO-microspheres (Zhou et al, 2005(Zhou et al, , 2012 and 4-20 folds higher than that of reported ATO-nanoparticles (Yang et al, 2009;Ellison et al, 2017;Lu et al, 2018;Hu et al, 2019;Lian et al, 2019). The encapsulation efficiency was 21.6%, which was at the similar level as previously reported studies (Lu et al, 2018;Lian et al, 2019).…”

Section: Discussionsupporting

confidence: 75%

“…While non-resorbable beads are currently used for chemoembolization on clinic, resorbable drug-eluting beads gained a lot of focus as they have advantages of transient embolization, not interfering repeat chemoembolization, and complete drug releasing (Marelli et al, 2007;Weng et al, 2011;Choi et al, 2015;Lee et al, 2018). PLGA is a biocompatible and biodegradable polymer and Yang et al used modified PLGA to form ATO-loaded nanoparticles and reached drug load of 10.08%, the highest previously reported value (Yang et al, 2009). In current study, we chose PLGA to make ATOloaded microspheres and did not observe any adverse effect from PLGA.…”

Section: Discussionmentioning

confidence: 99%

Chemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal

et al. 2020

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Chemoembolization for hepatocellular carcinoma (HCC) is often suboptimal due to multiple involved signaling and lack of effective drugs. Arsenic trioxide (ATO) is a potent chemotherapeutic agent, which can target multiple signaling and have substantial efficacy on HCC. However, its usage is limited due to systemic toxicity. Using ATO-eluting beads/microspheres for chemoembolization can have locoregional drug delivery and avoid systemic exposure but will require high drug load, which has not been achieved due to low solubility of ATO. Through an innovative approach, we generated the transiently formed ATO microcrystals via micronization and stabilized these microcrystals by solvent exchange. By encapsulating ATO microcrystals, but not individual molecules, with poly(lactide-co-glycolic acid) (PLGA), we developed microspheres cored with extremely high dense ATO. The molar ratio between ATO and PLGA was 157.4:1 and drug load was 40.1%, which is 4–20 fold higher than that of reported ATO nano/microparticles. These microspheres sustainably induced reactive oxygen species, apoptosis, and cytotoxicity on HCC cells and reduced tumor growth by 80% via locoregional delivery. Chemoembolization on mice model showed that ATO-microcrystal loaded microspheres, but not ATO, inhibited HCC growth by 60–75%, which indicates ATO within these microspheres gains the chemoembolizing function via our innovative approach.

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“…Most chemotherapies are expensive and cause serious side effects ranging from nausea, vomiting, mucositis, ulceration and necrosis of the colon to acute myeloid leukemia with a preleukemic phase and heart failure. 15 Several reports clearly show that different types of magnetic nanoparticles are toxic to different types of cancer cells cultured in vitro including human SK-MEL-37 melanoma cells, 16 human osteosarcoma Saos-2 cells, 17 and cervical adenocarcinoma HeLa cells. 18 Current paradigms of apoptosis suggest that in mammalian cancer cells, the magnetic nanoparticles activate the oxidative stress by increasing reactive oxygen species (ROS) levels and depleting the antioxidant glutathione, which result in the induction of apoptosis via p53, survivin, bax/bcl-2, and caspase pathways.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin

Al‐Qubaisi¹,

Abdullah²,

Flaifel³

et al. 2013

IJN

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Abstract:In this study, in vitro cytotoxicity of nickel zinc (NiZn) ferrite nanoparticles against human colon cancer HT29, breast cancer MCF7, and liver cancer HepG2 cells was examined. The morphology, homogeneity, and elemental composition of NiZn ferrite nanoparticles were investigated by scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. The exposure of cancer cells to NiZn ferrite nanoparticles (15.6-1,000 µg/mL; 72 hours) has resulted in a dose-dependent inhibition of cell growth determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The quantification of caspase-3 and -9 activities and DNA fragmentation to assess the cell death pathway of the treated cells showed that both were s timulated when exposed to NiZn ferrite nanoparticles. Light microscopy examination of the cells exposed to NiZn ferrite nanoparticles demonstrated significant changes in cellular morphology. The HepG2 cells were most prone to apoptosis among the three cells lines examined, as the result of treatment with NiZn nanoparticles. In conclusion, NiZn ferrite nanoparticles are suggested to have potential cytotoxicity against cancer cells.

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Preparation, characterization, in vivo and in vitro studies of arsenic trioxide Mg-Fe ferrite magnetic nanoparticles

Cited by 19 publications

References 17 publications

Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure

Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure

Chemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal

Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin

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Preparation, characterization, in vivo and in vitro studies of arsenic trioxide Mg-Fe ferrite magnetic nanoparticles

Cited by 19 publications

References 17 publications

Cytotoxic Effect of Nanocrystalline MgFe2O4 Particles for Cancer Cure

Cytotoxic Effect of Nanocrystalline MgFe2O4 Particles for Cancer Cure

Chemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal

Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin

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Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure

Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure