Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure

Abstract

Nanocrystalline magnesium ferrites (MgFe2O4) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2O4nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μg/mL) against MCF-7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe2O4nanoparticles in a dose-dependent manner. Flow cytometry analysis shows that MgFe2O4nanoparticles in 800 μg/mL concentration are more cytotoxic compared to vehicle-treated MCF-7 cells and suggests their potential utility as a drug carrier in the treatment of cancer.

Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

“…The wide band around 3425 in Figure 2a and 3447 in Figure 2b and absorption peaks at 1652 in Figure 2a and 1633 in Figure 2b correspond to the respective hydroxyl group [41,42]. A sharp peak around 1388 cm´1 in both the spinel ferrites is attributed to the symmetric vibration of the NO 3ǵ roup [41].…”

“…The small absorption peaks around 2927 and 2855 cm −1 in zinc ferrite are ascribed to the anti-symmetric and symmetric-CH2-vibrations of the carbon chains [43]. Generally, the metal oxide vibrations occur below 1000 cm −1 [41]. Fe-O-H bending vibrations were observed at 797 cm −1 [44].…”

“…The wide band around 3425 in Figure 2a and 3447 in Figure 2b and absorption peaks at 1652 in Figure 2a and 1633 in Figure 2b correspond to the respective hydroxyl group [41,42]. A sharp peak around 1388 cm −1 in both the spinel ferrites is attributed to the symmetric vibration of the NO3 − group [41]. The small absorption peaks around 2927 and 2855 cm −1 in zinc ferrite are ascribed to the anti-symmetric and symmetric-CH2-vibrations of the carbon chains [43].…”

“…The average particle size is found to be 56 nm for CuFe2O4 and 68 nm ZnFe2O4, respectively. Spinel ferrite particles generally have a spherical shape with smooth surfaces and a narrow size distribution [41,46]. …”

“…The average particle size is found to be 56 nm for CuFe2O4 and 68 nm ZnFe2O4, respectively. Spinel ferrite particles generally have a spherical shape with smooth surfaces and a narrow size distribution [41,46]. Figure 4a,b shows the room-temperature magnetic hysteresis loops of the CuFe2O4 and ZnFe2O4 nanoparticles prepared by the sol-gel self-combustion technique.…”