Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite

Al‐Qubaisi, Mothanna Sadiq; Al-Abboodi, Ashwaq Shakir; Alhassan, Fatah H.; Hussein‐Al‐Ali, Samer Hasan; Flaifel, Moayad Husein; Eid, Eltayeb E M; Mediani, Ahmed; Hussein, Mohd Zobir; Alnasser, Sulaiman Mohammed; Saeed, Mohammed Ibrahim; Abdullah, Rasedee; Ibrahim, Wisam Nabeel

doi:10.1016/j.jsps.2022.02.002

Cited by 9 publications

(4 citation statements)

References 46 publications

(47 reference statements)

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“…Chitosan controls bleeding by adsorption of plasma and coagulation of red blood cells. 17,24 The interaction of cationic chitosan with the anionic cell surface, increased membrane permeability and leakage of cellular material from the cell may be the antibacterial mechanism of chitosan. Chitosan can also interfere with mRNA production and protein incorporation.…”

Section: Chitosan Mechanism Of Actionmentioning

confidence: 99%

“…2,12,26. Due to its outstanding characteristics such as absorbency, malleability and cohesive concentration threshold to store and gradually release drugs with optimal resorption, it has been previously used as a transport system for local drug delivery, mucoadhesives, multiparticulate parenterals and floating orals. 24 Chitosan has immunomodulatory properties, stimulating macrophages to release IL-1, which in turn stimulates fibroblast and collagen proliferation. It promotes effective wound healing and regeneration of soft, bone and nerve tissues.…”

Section: Chitosan Mechanism Of Actionmentioning

confidence: 99%

“…It has been used to repair the alveolus after tooth extraction, in guided bone regeneration, hemostasis of surgical wounds in oral reconstruction, repair of temporomandibular joint discs. 13,14,24,26 7. In prosthetic dentistry, it is used for the modification of glass ionomer restoratives and the antibacterial activity of dental adhesive and the modification of lithium disilicate glass-ceramic luting procedures.…”

Section: Biological Effects Of Chitosan In Dentistrymentioning

confidence: 99%

“…The use of polymeric drug vehicles proved to be a very successful technique to formulate micro-and nanoparticles with controlled or targeted drug release in the oral cavity. 24,25,37 9. In pediatric dentistry, chitosan is used to prevent mucoadhesion of cariogenic bacteria.…”

Section: Biological Effects Of Chitosan In Dentistrymentioning

confidence: 99%

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Biological effects of chitosan in Dentistry

Nava Juárez

2023

Mex J Med Res

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Current research in the world has focused on studies of biomaterials in the medical area, leaving an emerging research model in dentistry, with little information available. In this sense, there are several biomaterials with potential to be used in various areas of dentistry, mainly in endodontics. Chitosan is a versatile biomaterial from its production to its multiple properties, applications and benefits. Chitosan is a biomolecule with an average molecular weight of 100 to 500 kDa, obtained from the exoskeleton of arthropods such as crabs, shrimps, lobsters and mollusks (squids, oysters, cuttlefish). Its chemical structure is similar to cellulose, formed by amino and hydroxyl functional groups in its polymeric structure, soluble in aqueous media. Several studies have considered chitosan as a safe product for biomedical use. It is currently used in the food industry for its fat absorption capacity, helping in weight loss for the control of overweight-obesity, as well as food preservation, cosmetics manufacturing, antioxidants, among others. Some of its properties in the medical area include its potent bactericidal, hemostatic and tissue regenerative effect. Giving improved results thanks to its great properties of biocompatibility, biodegradability, low toxicity and great antimicrobial potential. However, more clinical studies are needed to know its benefits and what its use in the clinical area implies. Therefore, the present manuscript aims to provide existing information on chitosan for the research and development of new, safer and more effective dental materials.

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Section: Chitosan Mechanism Of Actionmentioning

confidence: 99%

Section: Chitosan Mechanism Of Actionmentioning

confidence: 99%