Preparation, characterization, in vitro cell cytotoxicity and biological studies of Pd(II), Ag(I), Pt(IV) and Hg(II) piroxicam anti-inflammatory drug complexes

Abstract

Novel Pd(II), Ag(I), Pt(IV) and Hg(II) piroxicam (Pir) anti-inflammatory drug complexes were obtained upon the reaction of metal salts with piroxicam (Pir) in ethanol solvent at 60 °C. The proposed structure was explained with the aid of microanalytical analyses, conductivity, spectroscopic (FT-IR and UV-Vis.), magnetic calculations and thermogravimetric analyses (TG/TGA). The ratio of metal: Pir drug is found to be 1:2 in all complexes estimated by using molar ratio method. The conductance data reveal that Pd(II), Pt(II) and Hg(II) chelates are non-electrolytes except Ag(I) complex. The infrared spectrum of free piroxicam in comparison with its chelates indicated that the chelation mode occurs via the oxygen and nitrogen atoms of ν(C=O)carbonyl and ν(C=N) pyridyl, respectively. The kinetic parameters of thermogravimetric and its differential, such as activation energy, entropy of activation, enthalpy of activation, and Gibbs free energy were evaluated using Coats-Redfern and Horowitz-Metzger equations for Pir drug and its complexes. The antimicrobial tests were assessed toward some types of bacteria and fungi. The in-vitro cell cytotoxicity of the complexes in comparison with Pir against colon carcinoma (HCT-116) cell line was investigated.

Novel Schiff Bases Ligands and Their Complexes: Thermal Analysis, Antibacterial Activity, and Molecular Docking

“…A wealth of articles that extend from pure synthesis to contemporary physically-and biochemically-relevant investigations indicate that the metal complexes of β-ketoenamine ligands have played an essential role incoordination chemistry-based studies [19][20][21][22][23][24][25]. Furthermore, the broad-ranging biological and pharmacological consequence of diverse Schiff base metal complexes has piqued the curiosity of researchers [26][27][28][29][30]. Transition metal complexes are most commonly used in the medical field to test antibacterial and anticancer medications in the hopes of developing a feasible and safe treatment for bacterial interactions and cancer [31][32][33].…”