Preparation, Characterization and Tests of Incorporation in Stem Cells of Superparamagnetic Iron Oxide

Environmental implications and applications of engineered nanoscale magnetite and its hybrid nanocomposites: A review of recent literature

“…Given that SPION toxicity mainly stems from oxidative stress, surface modification with an antioxidant (such as N-Acetylcysteine or Trolox) may be a new method to suppress oxidative damage and injury. The thiolated SPIONs with mercaptosuccinic acid (MSA) and cysteine (Cys) have no toxic effects for stem cells [118]. Long-term in vivo studies in murine models have shown that dimercaptosuccinic acid (DMSA)-coated MNPs accumulate in spleen, liver and lung tissues during extended periods of time (at least up to 3 months) without any significant signs of toxicity detected [119].…”

Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications

“…Superparamagnetic iron oxide nanoparticles, such as Fe 3 O 4 (magnetite), have been employed in a variety of biomedical applications, including diagnostics and drug delivery. [1][2][3][4][5][6][7][8][9][10] Due to the superparamagnetic behavior of Fe 3 O 4 at room temperature, these NPs have a large constant magnetic moment and act as a giant paramagnetic atom, quickly responding to applied magnetic elds without residual magnetism and coercivity. This behavior makes Fe 3 O 4 NPs attractive in a number of biomedical applications.…”

Potential Use of DMSA‐Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID‐19 Disease

“…[25] Studies show that DMSA-coated iron oxide nanoparticles can greatly enhance the rate of cellular acceptance, leading to nonspecific adsorption to the cell surface, followed by endocytosis. [8,26,27] Taking advantage of DMSA-SPIONs, in this study, we obtained Fe 3 O 4 nanoparticles by the co-precipitation method using ferrous and ferric chlorides in an aqueous solution.…”

“…In the last decades, the use of superparamagnetic iron oxide nanoparticles (SPIONs) in biomedicine and pharmaceutical sciences were carefully investigated, especially magnetite nanoparticles (Fe 3 O 4 ), once they have been successfully used in different biomedical applications such as drug delivery, contrast agents for imaging, controlled drug release, hyperthermia, among others[ 6 , 7 , 8 , 9 ] SPIONs present superparamagnetic behavior and act as a single magnetic domain [10] providing fast response under an external magnetic field and consequently can be guided to a specific target. [8] In addition, when the magnetic field is removed, no residual magnetization remains, avoiding agglomeration of the nanoparticles in vivo. [11] This feature permits the guided administration of these nanoparticles to the target tissue/organ with minimum side effects.…”