Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder

Sun, Fengying; Sui, Cheng; Zhou, Yanmin; Liu, Ximing; Shi, Yanan; Wu, Yi Hui; Li, Youxin

doi:10.1016/j.ijpharm.2013.07.041

Cited by 15 publications

(9 citation statements)

References 19 publications

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“…Sun [23] Method: Experiment carbopol 940 is a good material for topical delivery of tolterodine, giving a significantly higher yield of drug release than carbopol 934 and 980. 9 Aslani [24] Method: Experiment Formula 5 containing 1% carbopol 940 and 3% sodium CMC more mucoadhesive than Formula 4 containing 0.5%carbopol 940 and 3% sodium CMC.…”

Section: Methodsmentioning

confidence: 99%

Overview: Application of Carbopol 940 in Gel

Safitri¹,

Nawangsari²,

Febrina³

2021

Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)

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Carbopol is an acrylic polymer. Carbopol is non-toxic and non-irritating so that it is suitable for gel preparations. Carbopol 940 is often used as a gelling agent in gel preparations. Concentration of carbopol 940 as a gelling agent needs to be concerned to obtain a good gel preparation. This study aimed to determine the effect of carbopol 940 concentration on physical properties, drug release and the use in eye drops. The research method used was descriptive method with data collection technique using PICO (Population, Intervention, Compare, Outcame) approach. Based on the Descriptive research results, it was obtained that carbopol 940 had influences on the physical properties of the gel in the form of pH, viscosity, spreadability, adhesion, organoleptic and stability. Carbopol 940 is commonly used in controlled-release drug formulations. In addition, carbopol 940 is also safe to use in eye drops preparations which do not cause irritation in in vivo testing.

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Section: Methodsmentioning

confidence: 99%

Overview: Application of Carbopol 940 in Gel

Safitri¹,

Nawangsari²,

Febrina³

2021

Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)

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“…The vesicles were pelleted by centrifugation at 12,000× g at 5 °C for 30 min (5810R; Eppendorf, Hamburg, Germany). The supernatant layer was collected to measure free drug by high-performance liquid chromatography (HPLC) [ 15 ]. The percentage EE ( Table 1 ) was calculated using the following equation.…”

Section: Methodsmentioning

confidence: 99%

“…The sample (1 mL) from the receptor compartment was collected every hour for 8 h and an equal volume of fresh phosphate buffer saline, pH 7.4, was added immediately [ 16 , 17 ]. The amount of TT, from the proniosomal gel, in each sample was analyzed by reverse-phase HPLC eluted at 1 mL/min with a mobile phase of methanol:20 mM pH 3.0 acetate buffer (65:35, v / v ), measured at 281 nm with a ultraviolet (UV) detector [ 15 ]. Likewise for in vitro permeation studies, freshly excised rat skin was used under same conditions.…”

Section: Methodsmentioning

confidence: 99%

Tolterodine Tartrate Proniosomal Gel Transdermal Delivery for Overactive Bladder

et al. 2016

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The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation. Formulations were analyzed for drug entrapment efficiency (EE), vesicle size, surface morphology, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, in vitro skin permeation, and in vivo effects. The EE was 44.87%–91.68% and vesicle size was 253–845 nm for Span formulations and morphology showed a loose structure. The stability and skin irritancy test were also carried out for the optimized formulations. Span formulations with cholesterol-containing formulation S1 and glyceryl distearate as well as lecithin containing S3 formulation showed higher cumulative percent of permeation such as 42% and 35%, respectively. In the in vivo salivary secretion model, S1 proniosomal gel had faster recovery, less cholinergic side effect on the salivary gland compared with that of oral TT. Histologically, bladder of rats treated with the proniosomal gel formulation S1 showed morphological improvements greater than those treated with S3. This study demonstrates the potential of proniosomal vesicles for transdermal delivery of TT to treat OAB.

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“…The sample was measured in UV at a 281 nm wavelength with 35:65, V/V of mobile phase (20 mM pH 3.0 acetate buff er/methanol) at an elution rate of 1 mL min -1 . The retention time was 5.5 min (15).…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

“…Zhao reported that the fl ux of TT solution was not aff ected by addition of O-acylmenthol derived chemical enhancers but skin reservoir eff ects of enhancer-containing groups showed promising results compared to the control group (14). Choi reported that free base TT penetrated hairless mouse skin about 10 times more eff ectively compared to other lipophilic salt forms (15). Elshafeey et al developed controlled release of the drug into the systemic circulation with the use of TT microemulsion, which was advantageous in prevention of nocturnal enuresis with improvement in patient compliance (16).…”

mentioning

confidence: 99%

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

et al. 2017

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Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluationThe purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its effi cacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Diff erential scanning calorimetry and Fourier transform infrared analyses were also performed. To determine patch eff ectiveness, in vitro release, permeation and animal studies were performed. The patches showed satisfactory percentage of release, up to 89.9 %, and their mechanical properties included thickness (0.10-0.15 mm), tensile strength (4.62-9.98 MPa) and modulus of elasticity (20-29 MPa). There were no signifi cant interactions between TT and other excipients. Animal studies indicated that the TT patch reduced the incidence of side eff ects; however, studies of longer duration are required to determine the eff ectiveness in treating OAB.

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Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder

Cited by 15 publications

References 19 publications

Overview: Application of Carbopol 940 in Gel

Overview: Application of Carbopol 940 in Gel

Tolterodine Tartrate Proniosomal Gel Transdermal Delivery for Overactive Bladder

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

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