Overview: Application of Carbopol 940 in Gel

Safitri, Fenny Indah; Nawangsari, Desy; Febrina, Dina

doi:10.2991/ahsr.k.210127.018

Cited by 41 publications

(35 citation statements)

References 11 publications

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“…For instance, different grades of CP were formulated in a study to deliver meloxicam, and it was found that none of the formulation prepared in the study demonstrated pharmaceutical instability problems during accelerated stability testing [ 54 ]. However, there are studies that support that a change in the pH of the CP-based gel formulations during the stability study can impart change in the viscosity of the formulations [ 55 ]. Nevertheless, the pH of the optimized formulation in the current study did not change significantly over time ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

et al. 2022

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Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that is converted to hydrocolloid gel in hot water with notable gel strength. Currently, its mucoadhesion properties have not been fully explored. Therefore, the main aim of this study was to evaluate the mucoadhesive potential of AG binary dispersions in combination with Carbopol 934P (CP) as mucoadhesive gel preparations. The gels fabricated via homogenization were evaluated for ex vivo mucoadhesion, swelling index (SI), dissolution and stability studies. The mucoadhesive properties of AG were concentration dependent and it was improved by the addition of CP. Maximum mucoadhesive strength (MS) (27.03 g), mucoadhesive flow time (FT) (192.2 min), mucoadhesive time in volunteers (MT) (203.2 min) and SI (23.6% at 4 h) were observed with formulation F9. The mucoadhesive time investigated in volunteers (MT) was influenced by AG concentration and was greater than corresponding FT values. Formulations containing 0.3%, w/v AG (F3 and F9) were able to sustain the release (~99%) for both drugs till 3 h. The optimized formulation (F9) did not evoke any inflammation, irritation or pain in the buccal cavity of healthy volunteers and was also stable up to 6 months. Therefore, AG could be considered a natural and potential polymer with profound mucoadhesive properties to deliver drugs through the mucosal route.

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Section: Resultsmentioning

confidence: 99%

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

et al. 2022

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“…It is a hydrophilic, non-toxic, and non-irritating synthetic polymer often used in the pharmaceutical industry as a base for soft dosage forms. The advantage of this polymer is its ability to form gels in water at room temperature within a wide pH range (from 4 to 10) [ 45 ]. The amount of Carbopol ® 940 affects the consistency of the composition [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels

et al. 2022

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Abietic acid, a naturally occurring fir resin compound, that exhibits anti-inflammatory and wound-healing properties, was formulated into biocompatible emulgels based on stable microemulsions with the addition of a carbamate-containing surfactant and Carbopol® 940 gel. Various microemulsion and emulgel formulations were tested for antioxidant and wound-healing properties. The chemiluminescence method has shown that all compositions containing abietic acid have a high antioxidant activity. Using Strat-M® skin-modelling membrane, it was found out that emulgels significantly prolong the release of abietic acid. On Wistar rats, it was shown that microemulsions and emulgels containing 0.5% wt. of abietic acid promote the rapid healing of an incised wound and twofold tissue reinforcement compared to the untreated group, as documented by tensiometric wound suture-rupture assay. The high healing-efficiency is associated with a combination of antibacterial activity of the formulation components and the anti-inflammatory action of abietic acid.

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“…It's because Formula 1 and 3 contain less gelling agent (1.0% of Carbopol). It is known that the lower concentration of Carbopol will increase the gel capability to spread [28]. On the other side, the viscosity of Formula 1 and 3 are lower than Formula 2 and 4.…”

Section: Spreadability and Viscosity Testmentioning

confidence: 97%

“…In order for a wound-healing preparation to assist this process, its pH must not be more than 6.0. Carbopol as the gelling agent, naturally has acidic pH, so it needs to be neutralized to reach the targeted pH of formulation [28]. Triethanolamine (TEA) as the pH adjuster plays the important role to alkalize the gel's pH.…”

Section: Organoleptic and Phmentioning

confidence: 99%

Formulation and Evaluation of Wound Healing Gel of White Leadtree (Leucaena Leucocephala (Lam.) De Wit.) Leaves Extract

Veronica

DWIASTUTI

2022

Int J App Pharm

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Objective: The aim of this research is to formulate and evaluate the wound healing gel of Leucaena leucocephala leaves extract. Methods: In this research, the extract of Leucaena leaves was formulated into wound healing gel by using a variation of the concentration of Carbopol as a gelling agent and Propylene glycol as a humectant. Afterward, the gel's physical properties (pH, viscosity, spreadability), stability, and sterility were tested. The wound healing activity was evaluated by making excision wounds on the Wistar Albino rat's back, and then the gels were applied to the wound every day. The wound's size was measured and counted as the percentage of wound closure. Results: The result showed that Formula 4 (contains 1.5% of Carbopol and 12% of Propylene glycol) has the best physical characteristics and wound healing activity. Formula 4 showed 100% wound closure on the 11th day of the treatment, while the negative control only reached 49.12%. The statistical parameter with the p-value<0.05 stated that they are significantly different. Conclusion: This research demonstrated that gel with Leucaena leaf extract has good physical characteristics, and it can significantly improve the wound healing process.

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Overview: Application of Carbopol 940 in Gel

Cited by 41 publications

References 11 publications

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

Supramolecular Tools to Improve Wound Healing and Antioxidant Properties of Abietic Acid: Biocompatible Microemulsions and Emulgels

Formulation and Evaluation of Wound Healing Gel of White Leadtree (Leucaena Leucocephala (Lam.) De Wit.) Leaves Extract

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