Formulation and Evaluation of Wound Healing Gel of White Leadtree (Leucaena Leucocephala (Lam.) De Wit.) Leaves Extract

Veronica, Evy Fenny; DWIASTUTI, RINI

doi:10.22159/ijap.2022v14i1.42126

Cited by 5 publications

(4 citation statements)

References 24 publications

(32 reference statements)

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“…The other essential factors are the viscosity and spreadability of the nanoemulgel preparations. These two factors affect the retention time of the trial and application to the skin area, which will impact the therapy's effectiveness [29]. The viscosity measurement was done on day one, three, and six after nanoemulgel preparation.…”

Section: Viscosity and Spreadability Testsmentioning

confidence: 99%

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Chrismaurin

DWIASTUTI²,

Chabib³

et al. 2023

Int J App Pharm

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Objective: This research aims to evaluate the effect of olive oil, tween 60, and span 20 on the physical properties of quercetin nanoemulgel. Methods: In this research, quercetin was formulated into nanoemulgel using a variation of olive oil, tween 60, span 20, and sodium alginate as a gelling agent. The nanoemulgel physical properties (pH, viscosity, and spreadability), stability, and particle size were tested. The data were measured and evaluated using Minitab®18 software; if the p-value<0.05, it is stated that there is a statistically significant difference in the formula. Results: The result showed that tween 60 has the greatest significant impact on pH, viscosity, and transmittance value with a p-value<0.05 for all, meanwhile span 20 has the greatest significant impact on the spreadability of the nanoemulgel preparations with a p-value<0.05 indicating that they are significantly different. Conclusion: This study reported that the effect of olive oil, tween 60 and span 20, with different variations, significantly impacts the physical properties (pH, viscosity, and spreadability) of the nanoemulgel.

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Section: Viscosity and Spreadability Testsmentioning

confidence: 99%

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Chrismaurin

DWIASTUTI²,

Chabib³

et al. 2023

Int J App Pharm

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“…The spreadability of nanoemulgel was measured 24 h after preparation. In this test, 1 gram of gel was placed in the middle of a glass plate and given a weight of 150 grams combined, allowed to stand for 1 min, then the diameter of the distribution was measured with a caliper [28,29].…”

Section: Spreadabilitymentioning

confidence: 99%

Optimization and Physical Characterization of Quercetin Nanoemulgel Formula as an Antibacterial Agent

2023

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Objective: This research aims to optimize the quercetin nanoemulgel formula to improve quercetin solubility as an antibacterial agent. Methods: In this research, quercetin was formulated into nanoemulgel with the factorial design of three independent variables, the concentration of oil phase (virgin coconut oil), surfactant (Tween 80), and co-surfactant (Span 80). The nanoemulgel physical properties (viscosity, spreadability, transmittance value, zeta potential, and particle size) were tested. The data were evaluated using Minitab®18 software; if the p-value<0.05, it is stated that there is a statistically significant difference in the formula, and the use of the response optimizer menu in the Minitab® 18 software determines the optimum formula with multiple responses. Results: The results showed that the concentration of quercetin used to inhibit the growth of Staphylococcus aureus was 2 mg/ml. The size of the particles had a mean of 62.487 nm, the polydispersity index had a mean of 0.365, and the percent transmittance had a mean of 95.533±0.113%. Measurements of the zeta potential had a mean of -26.712±0.154, with the viscosity and spreadability of the preparations made having a mean of 2495±0.250 cps and 4.795±0.028 cm. Conclusion: This study reported that the VCO amount of 3g, the tween amount of 12g and the span amount of 3.5g were found to be computational recommendations to achieve the optimum conditions only for percent transmittance value response.

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“…A gelling agent will form a gel matrix. At the same time, a humectant will maintain the stability of gel preparation by absorbing moisture and reducing water evaporation in the gel to overcome syneresis [13,14]. One of the humectants frequently used for gel preparation is propylene glycol (PG).…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Physical Characteristics and Shelf Life of Rice Water (Oryza Sativa L.) Gel Shampoo: The Role of Propylene Glycol Concentration

CHABIB,

SURYANI,

MUNAWIROH

et al. 2024

Int J App Pharm

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Objective: This study aims to determine the effect of variations in propylene glycol concentration on the physical properties and physical stability of rice water shampoo gel and the physical strength of rice water shampoo gel preparation. Methods: The active ingredient was rice water, which was prepared by washing rice with water at the proportion of 1:1. The rice water then was applied to HPMC K4M-based gel preparations and further designed to prepare shampoo gel with varying concentrations of propylene glycol 8%, 10%, and 12%. The rice water shampoo gel was evaluated for its organoleptic properties, pH, viscosity, spreadability, flowability test, softness test, and physical stability test. Results: The results of the physical properties test on the three formulas produced an organoleptic clear pale yellow color, lemon odor, and semi-solid shape. The pH test results obtained by F1 was 7.24±0.08, F2 was 5.89±0.01, and F3 was 6.02±0.01. The viscosity test results obtained by F1 amounted to 2082±80.07 cP, F2 amounted to 4987±883.88 cP, and F3 amounted to 6531±232.79 cP. The foam height test results obtained by F1 amounted to 4.6±2.11 cm, F2 amounted to 1.46±0.05 cm, and F3 amounted to 1.7±0.17 cm. Variations in propylene glycol levels affect the physical properties of shampoo gel preparations at pH, viscosity, and foam height but do not affect the organoleptic practice. The stability test that was conducted at weeks 0, 1, 2, 3, and 4 with varying levels of propylene glycol showed significant changes on viscosity and foam height stability. Conclusion: Variations in the concentrations of propylene glycol in the three formulations affect the physical but have no effects on the pH stability of the rice water shampoo gel preparation.

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Formulation and Evaluation of Wound Healing Gel of White Leadtree (Leucaena Leucocephala (Lam.) De Wit.) Leaves Extract

Cited by 5 publications

References 24 publications

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Optimization and Physical Characterization of Quercetin Nanoemulgel Formula as an Antibacterial Agent

Enhancing the Physical Characteristics and Shelf Life of Rice Water (Oryza Sativa L.) Gel Shampoo: The Role of Propylene Glycol Concentration

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