Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization

Mosafer, Jafar; Sabbaghi, Amir-Hossein; Badiee, Ali; Dehghan, Solmaz; Tafaghodi, Mohsen

doi:10.1016/j.ajps.2018.04.005

Cited by 51 publications

(30 citation statements)

References 33 publications

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“…PR8-chitosan formulation elicited higher IgG2a and IgG1 antibody titers compared with PR8-TMC. Alginate coating significantly decreased the antibody titers and less immune response was induced [ 121 ].…”

Section: Toxicity and In Vivo Studymentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

130

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Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.

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Section: Toxicity and In Vivo Studymentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

130

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“…Oral vaccine with plasmid-cured Salmonella enterica serovar Gallinarum, included in alginate-coated chitosan microparticles, induced higher expression of INF-γ and the same protection of chickens compared with the commercial fowl typhoid vaccine introduced parenterally [107]. Alginate-coated trimethylchitosan nanoparticles loaded with inactivated PR8 influenza virus generated a much higher IgG2a/IgG1 ratio than the non-coated ones and PR8 virus alone after intranasal administration [108].…”

Section: Adjuvant Familiesmentioning

confidence: 99%

Vaccine Adjuvants Derived from Marine Organisms

Sanina

2019

Biomolecules

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Vaccine adjuvants help to enhance the immunogenicity of weak antigens. The adjuvant effect of certain substances was noted long ago (the 40s of the last century), and since then a large number of adjuvants belonging to different groups of chemicals have been studied. This review presents research data on the nonspecific action of substances originated from marine organisms, their derivatives and complexes, united by the name ‘adjuvants’. There are covered the mechanisms of their action, safety, as well as the practical use of adjuvants derived from marine hydrobionts in medical immunology and veterinary medicine to create modern vaccines that should be non-toxic and efficient. The present review is intended to briefly describe some important achievements in the use of marine resources to solve this important problem.

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“…In the process of immunization against the influenza virus by the nasal route, the antigen, incorporated in chitosan-coated nanoparticles, crosses the epithelial barrier through microfold cells more easily, reaching the lymphoid tissue, associated with the nasal area, and dendritic cells more easily take over the nanoparticles. A previous study showed that chitosan is an immunoadjuvant because it obtained a superior immune response in mice that received chitosan-coated nanoparticles compared to the group that received uncoated nanoparticles [ 114 ].…”

Section: Chitosan In the Development Of Intranasal Vaccinesmentioning

confidence: 99%

“…The intranasal administration of polymeric nanoparticles containing various substances has several advantages, in addition to the general advantages of the nasal pathway: It prevents the enzymatic and chemical degradation of substances [ 106 ], increases the stability of volatile drugs, increases the residence time of substances at nasal mucosa, and has a better bioavailability [ 6 , 114 ]. The most commonly used mechanism for obtaining nanoparticles with the active substance is by introducing the active molecules during the nanoparticle manufacturing process, when the molecules are better fixed in the nanoparticle matrix.…”

Section: Chitosan-based Formulations For Intranasal Administrationmentioning

confidence: 99%

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

Popescu

Ghica

Dinu-Pîrvu

et al. 2020

IJMS

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In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

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Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization

Cited by 51 publications

References 33 publications

Current Status of Alginate in Drug Delivery

Current Status of Alginate in Drug Delivery

Vaccine Adjuvants Derived from Marine Organisms

New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

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