Preparation, characterization and immunological evaluation of alginate nanoparticles loaded with whole inactivated influenza virus: Dry powder formulation for nasal immunization in rabbits

Dehghan, Solmaz; Kheiri, Masoumeh Tavassoti; Abnous, Khalil; Eskandari, Maryam; Tafaghodi, Mohsen

doi:10.1016/j.micpath.2017.12.011

Cited by 27 publications

(14 citation statements)

References 56 publications

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“…Alginate nanoparticles have been used to deliver various drugs such as metformin [ 74 ], DOX [ 75 ], ethionamide [ 76 ] and several other drugs. Various administration routes of alginate nanoparticles are pulmonary [ 77 ], oral [ 75 ], nasal [ 78 , 79 ], intravenous [ 80 ], vaginal [ 81 ] and ocular [ 82 ].…”

Section: Polysaccharides Based Drug Carriersmentioning

confidence: 99%

Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

et al. 2022

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Cancer is one of the most widespread deadly diseases, following cardiovascular disease, worldwide. Chemotherapy is widely used in combination with surgery, hormone and radiation therapy to treat various cancers. However, chemotherapeutic drugs can cause severe side effects due to non-specific targeting, poor bioavailability, low therapeutic indices, and high dose requirements. Several drug carriers successfully overcome these issues and deliver drugs to the desired sites, reducing the side effects. Among various drug delivery systems, polysaccharide-based carriers that target only the cancer cells have been developed to overcome the toxicity of chemotherapeutics. Polysaccharides are non-toxic, biodegradable, hydrophilic biopolymers that can be easily modified chemically to improve the bioavailability and stability for delivering therapeutics into cancer tissues. Different polysaccharides, such as chitosan, alginates, cyclodextrin, pullulan, hyaluronic acid, dextran, guar gum, pectin, and cellulose, have been used in anti-cancer drug delivery systems. This review highlights the recent progress made in polysaccharides-based drug carriers in anti-cancer therapy.

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Section: Polysaccharides Based Drug Carriersmentioning

confidence: 99%

Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

et al. 2022

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“…Curcumin diglutaric acid Oral/parenteral [189] Amygdalin Oral [190] Chitosan-β-cyclodextrins Curcumin-folic acid Parenteral [214] Self-assembly -Doxorubicin-curcumin Parenteral [180] Spray drying TiO 2 nanoparticles Temozolomide Parenteral [193] Other applications Gelation method Tween 80-Span 80 Deactivated influenza virus Nasal/parenteral [206] -Polydopamine or alginate dopamine Parenteral [208] Polyelectrolyte complexation Phenylalanine ethyl ester-oleic acid -Parenteral [209] ε-polylysine Bovine serum albumin Parenteral [211] Polyethyleneimine siRNA Parenteral [210] Self-assembly -Ovalbumin Parenteral [205] Electrospraying -Plasmid DNA Parenteral [204] Table 1. Continued.…”

Section: Chitosanmentioning

confidence: 99%

“…[205] Yet, alginate NPs were explored for nasal immunization in rabbits toward the influenza virus. [206] These new nanocarriers increased the immune response likewise being able to increase the residence time in mucosal tissues. Alg-NPs loaded with the transforming growth factor β1 and β3 showed also great promise in promoting chondrogenesis for tissue engineering applications.…”

Section: Other Applicationsmentioning

confidence: 99%

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Dodero

Alberti

Gaggero

et al. 2021

Adv Materials Inter

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along with other polysaccharides (e.g., celluloses, chitosan, etc.), is indeed considered an extremely promising material in the viewpoint of circular economy and in substituting petroleum-derived polymers. [3] Among others, one of the reasons for alginate success is its unique capability to bind different cations leading to stable and tailor-made hydrogels. [4] Owing to its biocompatibility, biodegradability, and nontoxicity, in the past decades alginate has been vastly explored for drug and gene delivery, tissue engineering, and wound healing applications. [5] In this sense, the recent nanotechnological advances have allowed the fabrication and exploitation of alginate-based nanostructured materials with completely new capabilities. Thereby, it is not surprising that nowadays a broad variety of alginate-based nanomaterials with various shapes, sizes, and compositions are prepared via different approaches, including controlled gelation, electrospinning and electrospraying, self-assembly, phase-separation, and micro fluidics., All these nanostructures hold the potential to interact with living organisms much more efficiently with respect to bulk systems, hence leading to specific functionalities at the same time avoiding the occurrence of toxicity issues. [6][7][8] Despite the use of alginate-based nanomaterials has been reviewed in the past, the focus has been commonly pointed to their generic properties and applications. Conversely, this review attempts to provide a more specific and comprehensive summary limited to the most recent advances in the fabrication and use of two of the most common and promising alginatebased nanomaterials, namely nanoparticles (NPs) and electrospun nanofibers (NFs), with a focus on biomedical and pharmaceutical applications.

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“…Because influenza epidemics kill thousands around the world, so, improving the immunogenicity and performance of the vaccines is of great importance. In one study by Dehghan and co-workers, alginate nanoparticles were fabricated via ionic gelation technique and then, the influenza vaccine and adjuvants were incorporated into alginate nanoparticles [ 37 ]. Physico-chemical, as well as biological investigations, exhibited no influence of the encapsulation process on the construction and chemistry of protein.…”

Section: The Role Of Alginate-based Adjuvant and Vaccine Delivery System For Pandemic Strainsmentioning

confidence: 99%

Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review

Mallakpour

Azadi

Hussain

2021

International Journal of Biological Macromolecules

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Pathogen transmission is a widespread threat to global human health. Vaccines are very important during the outbreak of a pandemic. Destructive fractures caused by a sudden outbreak of COVID-19 have spurred vaccine production at an unprecedented rate. The strategy of an effective vaccine delivery system is opening up novel probabilities to make more immunization. Indeed, vaccination is the most successful way to prevent deaths from infectious diseases. In order to optimal immune response production or improvement in the effectiveness of vaccines, delivery systems or adjuvants are required. Natural polymers such as chitosan, alginate, hyaluronic acid, gums, and β-glucan with antiviral activity have good potential as adjuvant or delivery systems for vaccine formulation development and design vaccine delivery devices. According to the antiviral performance and immunomodulation of these biopolymers, they will play significant characters in the anti-COVID-19 field. In this mini-review, the recent progress in vaccine development by using biopolymers is presented which, provides a reference for their research on anti-COVID-19 drugs and vaccines.

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Preparation, characterization and immunological evaluation of alginate nanoparticles loaded with whole inactivated influenza virus: Dry powder formulation for nasal immunization in rabbits

Cited by 27 publications

References 56 publications

Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review

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