Preparation, characterization and <i>in vitro</i> activities evaluation of solid lipid nanoparticles based on PEG-40 stearate for antifungal drugs vaginal delivery

Cassano, Roberta; Ferrarelli, Teresa; Mauro, Maria Vittoria; Cavalcanti, Paolina; Picci, Nevio; Trombino, Sonia

doi:10.3109/10717544.2014.932862

Cited by 42 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SLNs have been obtained by the technique of the microemulsion [16][17][18][19][20][21][22][35][36][37]. The obtained ester, in the presence or in the absence of progesterone, was melted in a beaker at a temperature of about 70°C (temperature value higher than the melting temperature of the lipid).…”

Section: Preparation Of Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

“…Solid lipid nanoparticles (SLNs) are colloidal drug delivery systems able to transport lipophilic or hydrophilic molecules and can be obtained using different preparation approaches [12][13][14][15][16][17][18][19][20][21]. They are an alternative drug delivery system to other colloidal carriers, e.g., emulsions, liposomes, and polymeric nanoparticles, and very useful for the encapsulation, in particular, of drugs with poor water solubility such as progesterone [22].…”

Section: Introductionmentioning

confidence: 99%

“…The synthesis, involving the introduction of this amino acid, provided both protection and deprotection reactions in order to drive the coupling reaction between the protected amino acid and the synthesized ester. The obtained ester from the final synthesis was used as the lipid for the preparation of SLNs [16][17][18][19][20][21][22] useful as carriers of progesterone. All obtained compounds have been characterized by FT-IR and 1 H-NMR spectrophotometry.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solid Lipid Nanoparticles Based on L-Cysteine for Progesterone Intravaginal Delivery

Cassano

Trombino

2019

International Journal of Polymer Science

Self Cite

View full text Add to dashboard Cite

The present work has as its purpose the synthesis and characterization of a novel lipid material to be used in the preparation of solid lipid nanoparticles (SLNs) for the potential sustained release of progesterone in the vagina. For this reason, a material capable of ensuring the permanence of the formulation in the administration site for the time needed to guarantee the transmucosal absorption of the steroid was synthetized in order to reduce the number of administrations and to ensure an effective concentration of drug at the site of action. To this end, an ester, 2,3-dihydroxypropanoate of octadecyl (stearyl glycerine), containing two hydroxyl groups was initially synthesized. In particular, the hydroxyl group less sterically encumbered was functionalized with a thiol group, in a coupling reaction, with the amino acid L-cysteine. The obtained compound was characterized by FT-IR spectrometry and 1H-NMR. The functionalized lipid with L-cysteine was then used for the preparation of solid lipid nanoparticles that were loaded with progesterone. Finally, the release of progesterone from the lipid matrix based on newly synthesized ester, under conditions that simulate the vaginal physiological environment, was evaluated. All the obtained results suggest that the prepared nanoparticles could be used for the administration of progesterone, when its integration is essential, for example, in cases of threats of abortion or to increase fertility.

show abstract

Section: Preparation Of Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solid Lipid Nanoparticles Based on L-Cysteine for Progesterone Intravaginal Delivery

Cassano

Trombino

2019

International Journal of Polymer Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…PEG-40 stearate is a synthetic polyethyleneglycol lipid based on stearic acid, with 18 carbons in its chain, and glyceryl behenate is a lipid formed by glycerides of 22 carbon fatty acid and behenic acid. Previous reports indicated that stearic acid was able to emulsify with both poloxamer 188 and 407 in presence of PEG 4000 for lopinavir-loaded solid lipid nanoparticle formation, whereas glyceryl behenate, more hydrophobic, only emulsified with poloxamer 407, used herein, which has a larger proportion of more hydrophobic polyoxypropylene portion than polyoxyethylene [21][22][23]. Noteworthy, the use of these delivery systems for tyrosinase inhibition is an innovative aspect addressed herein.…”

Section: Introductionmentioning

confidence: 97%

Comparative Study of Glyceryl Behenate or Polyoxyethylene 40 Stearate-Based Lipid Carriers for Trans-Resveratrol Delivery: Development, Characterization and Evaluation of the In Vitro Tyrosinase Inhibition

et al. 2018

View full text Add to dashboard Cite

Trans-resveratrol (RSV) is a natural compound with several properties, such as the ability to inhibit the tyrosinase enzyme, with potential application as a skin-lightning agent and for the treatment of skin disorders associated with hyperpigmentation and melanogenesis. However, the drug faces several drawbacks which altogether limit its therapeutic application. Thus, drug loading into nanocarriers emerge as an alternative to circumvent these problems. Herein, nanostructured lipid carriers (NLCs) have been employed for RSV encapsulation, with comparison of two different lipids, glyceryl behenate (more hydrophobic), and polyoxyethylene 40 (PEG 40) stearate. PEG 40 stearate-containing NLCs presented smaller particle size and polydispersity compared with glyceryl behenate, attributed to better emulsification and nanoparticle formation, resulting in higher RSV encapsulation efficiency. Drug was loaded in both carriers as a molecular dispersion. Furthermore, the formulations had very low RSV release, which occurred due to the crystallinity degree of lipid matrix, in accordance with the DSC data. Moreover, RSV cytotoxicity against L-929 cells was not increased when loaded into nanocarriers. Interestingly, RSV-loaded formulation prepared with PEG-40 stearate resulted on greater tyrosinase inhibition than RSV solution and formulation containing glyceryl behenate, equivalent to 1.31 and 1.83 times higher, respectively, demonstrating that the incorporation of RSV into NLC allowed an enhanced tyrosinase inhibitory activity. Overall, the results obtained herein evidence potential for future in vivo evaluation of RSV-loaded NLCs.

show abstract

“…Solid lipid nanoparticles (SLNs) which were introduced in 1991 are used as alternative nanocarrier systems to traditional colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles (Cassano et al, 2014;Rostami et al, 2014;Pandey et al, 2015). Compared with these traditional colloidal carriers, SLNs offer the following advantages: improved biocompatibility; controlled drug release; potential for site-specific drug delivery, etc.…”

Section: Introductionmentioning

confidence: 99%

Folate-modified, cisplatin-loaded lipid carriers for cervical cancer chemotherapy

et al. 2015

View full text Add to dashboard Cite

Background: Cervical cancer chemotherapy calls for the efficiently delivery of anticancer drug into cancer cells by nanoparticles. In this study, folate (FA) modified, cisplatin (CIS)-loaded nanostructured lipid carriers (NLCs) were constructed and evaluated. Methods: FA containing polyethylene glycol (PEG)-distearoylphosphatidylethanolamine (DSPE) (FA-PEG-DSPE) was synthesized. FA-PEG-DSPE modified, CIS-loaded NLCs (FA-CIS-NLCs) were prepared. Their particle size, zeta potential, drug encapsulation efficiency (EE) and in vitro delivery behavior were evaluated. In vitro cytotoxicity study of FA-CIS-NLCs was tested in human cervix adenocarcinoma cell line (HeLa cells). In vivo anti-tumor efficacies of the carriers were evaluated on a mice-bearing cervical cancer model.

show abstract

Preparation, characterization and in vitro activities evaluation of solid lipid nanoparticles based on PEG-40 stearate for antifungal drugs vaginal delivery

Cited by 42 publications

References 20 publications

Solid Lipid Nanoparticles Based on L-Cysteine for Progesterone Intravaginal Delivery

Solid Lipid Nanoparticles Based on L-Cysteine for Progesterone Intravaginal Delivery

Comparative Study of Glyceryl Behenate or Polyoxyethylene 40 Stearate-Based Lipid Carriers for Trans-Resveratrol Delivery: Development, Characterization and Evaluation of the In Vitro Tyrosinase Inhibition

Folate-modified, cisplatin-loaded lipid carriers for cervical cancer chemotherapy

Contact Info

Product

Resources

About