Preparation, characterization and antitumor activity of a cationic starch-derivative membrane embedded with a β-cyclodextrin/curcumin inclusion complex

Gularte, Matheus S.; Quadrado, Rafael F.N.; Pedra, Nathália Stark; Soares, Mayara Sandrielly Pereira; Bona, Natália Pontes; Spanevello, Rosélia Maria; Fajardo, André R.

doi:10.1016/j.ijbiomac.2020.01.104

Cited by 43 publications

(11 citation statements)

References 66 publications

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“…The inclusion complex of curcumin with cyclodextrin polymer [ 23 , 51 , 52 , 53 , 54 ] and with cyclodextrin-based nanosponges [ 55 , 56 , 57 , 58 , 59 , 60 ] was studied thoroughly in previously published research and was reported to have an effect on the enhancement of curcumin solubility, release rate, stability, and cytotoxicity [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. However, there was no comparison between nanosponges and direct β-cyclodextrin complexations for curcumin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

2021

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Cyclodextrin polymers and cyclodextrin-based nanosponges have been widely investigated for increasing drug bioavailability. This study examined curcumin’s complexation stability and solubilization with β-cyclodextrin and β-cyclodextrin-based nanosponge. Nanosponges were prepared through the cross-linking of β-cyclodextrin with different molar ratios of diphenyl carbonate. Phase solubility experiments were conducted to evaluate the formed complexes and evaluate the potential of using β-cyclodextrin and nanosponge in pharmaceutical formulations. Furthermore, physicochemical characterizations of the prepared complexes included PXRD, FTIR, NMR, and DSC. In addition, in vitro release studies were performed for the prepared formulations. The formation of β-cyclodextrin complexes enhanced curcumin solubility up to 2.34-fold compared to the inherent solubility, compared to a 2.95-fold increment in curcumin solubility when loaded in β-cyclodextrin-based nanosponges. Interestingly, the stability constant for curcumin nanosponges was (4972.90 M−1), which was ten times higher than that for the β-cyclodextrin complex, where the value was 487.34 M−1. The study results indicated a decrease in the complexation efficiency and solubilization effect with the increased cross-linker amount. This study’s findings showed the potential of using cyclodextrin-based nanosponge and the importance of studying the effect of cross-linking density for the preparation of β-cyclodextrin-based nanosponges to be used for pharmaceutical formulations.

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Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

2021

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“…After heating for 6 h at 50 °C under continuous stirring, the pH of the mixtures was adjusted to 7.0 to terminate etherification reaction. Finally, the quaternary ammonium cationic starch was washed using absolute ethanol 3 times and lyophilized to obtain CLRS …”

Section: Methodsmentioning

confidence: 99%

“…Finally, the quaternary ammonium cationic starch was washed using absolute ethanol 3 times and lyophilized to obtain CLRS. 21 Preparation of Que-HQP-EGCG-CLRS Micelles. Initially, quercetin was dissolved in absolute ethanol to prepare quercetin stock solution (10 mg/mL).…”

Section: Preparation Of Cationic Lotus Root Starch (Clrs)mentioning

confidence: 99%

Hydrolytic Quinoa Protein and Cationic Lotus Root Starch-Based Micelles for Co-Delivery of Quercetin and Epigallo-catechin 3-Gallate in Ulcerative Colitis Treatment

Liu

Chen

et al. 2022

J. Agric. Food Chem.

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The accumulation and sustained release of drugs in the colonic inflammatory region are the favorable strategy for treating ulcerative colitis (UC). In this study, we developed a synergistic anti-inflammatory drug (quercetin/EGCG)-loaded micelle using hydrolytic quinoa protein (HQP) and cationic lotus root starch (CLRS) by a layer-by-layer assembly method. The encapsulation efficiency of quercetin and EGCG in the Que-HQP-EGCG-CLRS micelles reached 91.5 and 89.4%, respectively. This composite micelle exhibited a core−shell structure, where Que-HQP-EGCG was the core and CLRS was the coating shell. Moreover, the in vitro experiments indicated that these micelles can make Que/EGCG pass through gastric environments stably and delay their release in the intestine. Animal experiments further confirmed that the Que-HQP-EGCG-CLRS micelles can efficiently accumulate in the colonic inflammatory region and enable sustained release of drugs (more than 24 h), thus notably alleviating the symptoms of UC. These results suggested that Que-HQP-EGCG-CLRS micelles have good gastric stability, colonic inflammatoryaccumulated effect, and sustained drug release ability, which are a promising co-delivery system for UC treatment.

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“…A minimum (critical) concentration of cellulose is required to retain the integrity (shape) of the produced cryogel (i.e., to retain the integrity of the network after removing the liquid phase) [22,77,78]. This critical concentration is probably related to percolation within the precursor network [82,83], where overlap or interaction between cellulose chains results in the formation of an autonomous network [34]. At a concentration below the critical value, the network is unstable, and shrinkage increases with decreasing cellulose concentration [83].…”

Section: Concentration and Molecular Weight Of The Polymermentioning

confidence: 99%

Biopolymers in Drug and Gene Delivery Systems

2023

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[2007][2008][2009][2010][2011][2012][2013][2014][2015][2016]). Skorik's current research interests focus on the chemical modification and properties of polysaccharides; biopolymer drug and gene delivery systems-polymer-drug conjugates, microand nanoparticles, and polyplexes; and polysaccharide biomaterials for tissue engineering and regenerative medicine-films, nonwovens, sponges, and gels. To date, Dr. Skorik has co-authored more than 120 peer-reviewed publications (h-index 32 and 2600 total citations-Google Scholar).vii

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Preparation, characterization and antitumor activity of a cationic starch-derivative membrane embedded with a β-cyclodextrin/curcumin inclusion complex

Cited by 43 publications

References 66 publications

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

Hydrolytic Quinoa Protein and Cationic Lotus Root Starch-Based Micelles for Co-Delivery of Quercetin and Epigallo-catechin 3-Gallate in Ulcerative Colitis Treatment

Biopolymers in Drug and Gene Delivery Systems

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