Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

Abstract

Cyclodextrin polymers and cyclodextrin-based nanosponges have been widely investigated for increasing drug bioavailability. This study examined curcumin’s complexation stability and solubilization with β-cyclodextrin and β-cyclodextrin-based nanosponge. Nanosponges were prepared through the cross-linking of β-cyclodextrin with different molar ratios of diphenyl carbonate. Phase solubility experiments were conducted to evaluate the formed complexes and evaluate the potential of using β-cyclodextrin and nanosponge in pharmaceutical formulations. Furthermore, physicochemical characterizations of the prepared complexes included PXRD, FTIR, NMR, and DSC. In addition, in vitro release studies were performed for the prepared formulations. The formation of β-cyclodextrin complexes enhanced curcumin solubility up to 2.34-fold compared to the inherent solubility, compared to a 2.95-fold increment in curcumin solubility when loaded in β-cyclodextrin-based nanosponges. Interestingly, the stability constant for curcumin nanosponges was (4972.90 M−1), which was ten times higher than that for the β-cyclodextrin complex, where the value was 487.34 M−1. The study results indicated a decrease in the complexation efficiency and solubilization effect with the increased cross-linker amount. This study’s findings showed the potential of using cyclodextrin-based nanosponge and the importance of studying the effect of cross-linking density for the preparation of β-cyclodextrin-based nanosponges to be used for pharmaceutical formulations.

β-Cyclodextrin-Based Nanosponges Inclusion Compounds Associated with Gold Nanorods for Potential NIR-II Drug Delivery

“…Furthermore, the thermograms of the ICs indicate the disappearance of the characteristic peaks in the drugs, suggesting the complexation of the guests inside the cavities of NSs, while excluding the possibility of a physical mixture. Similar results have been observed for other NSs–drug complexes [ 43 , 45 , 62 , 63 , 64 , 65 , 66 ].…”

“…This suggests that MPH might be more aptly sized than CUR to be included in the supramolecular sites of NSs. The encapsulation efficiency and loading capacity values for NSs–CUR and NSs–MPH complexes increased, compared to native β-CD, where the calculated values were 30% (EE%) and 20% (LC%) for β-CD–CUR [ 65 , 73 ], and 70% (EE%) and 61% (LC) for β–CD–MPH [ 74 ].…”

Cyclodextrin-Based Nanosponges: Overview and Opportunities

“…The cavity of the CDs allows the inclusion of hydrophobic molecules and the more hydrophilic outer polymeric network is able to accommodate less lipophilic molecules. Furthermore, CDNSs combine high biocompatibility, biodegradability and low cytotoxicity, conferred by the cyclodextrins, with high thermal stability and insolubility that arises from the fact that they are highly crosslinked polymers ( Tejashri et al, 2013 ; Shende P. et al, 2015 ; Krabicová et al, 2020 ; Deng et al, 2021 ; Mashaqbeh et al, 2021 ). Thus, it is not surprising that this type of nanomaterials has been explored for the oral, topical and parenteral delivery of numerous drugs, in controlled drug delivery systems as, for example, for target cancer therapy ( Allahyari et al, 2022 ).…”

Novel Hydrogels for Topical Applications: An Updated Comprehensive Review Based on Source

“…Nanosponge (NS) is a novel preparation that is a nanoporous carrier with a sponge-like network shaped by hyper cross-linking polymeric materials to form three-dimensional covalent structures used to incorporate nanoparticles with a non-collapsible and porous formation [ 69 , 70 ]. Clobetasol propionate (CP), a potent topical corticosteroid, possesses a high therapeutic potential for psoriasis.…”