Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes

Liu, Shan; Li, Yunfei; Wang, Xiaowei; Ma, Jinling; Zhang, Lili; Xia, Guimin

doi:10.1016/j.xphs.2015.10.026

Cited by 13 publications

(11 citation statements)

References 25 publications

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“…In fact, using liposomes composed of DMPC, DMPG:DMPC (7:3 and 3:7) as well as DMPG, it was observed that the presence of DMPG was essential for the NDDP activity. These studies demonstrated that NDDP was inactive, and the reaction intermediate between DMPG and NDDP was the active product (Orena et al, 1991; Perez-Soler et al, 1991; Perez-soler and Khokhar, 1992; Liu et al, 2016). Interestingly, even though miriplatin has similar structure to NDDP, it is active on its own and does not require DMPG.…”

Section: Innovative Cisplatin-based Therapeutic Strategiesmentioning

confidence: 99%

“…Interestingly, even though miriplatin has similar structure to NDDP, it is active on its own and does not require DMPG. Nevertheless, the loading capacity of different liposomes to miriplatin was shown to be higher for DMPC, DMPG and DPPC in comparison to HSPC, DPPG, and DSPG (Liu et al, 2016).…”

Section: Innovative Cisplatin-based Therapeutic Strategiesmentioning

confidence: 99%

“…These modifications have been generally carried by chelation with anionic groups (e.g., carboplatin and oxaliplatin) or alterations to the amine (e.g., oxaliplatin) as can be observed in Figure 2. Furthermore, other substantial modifications to platinum(II) complexes have been tested including the addition of aliphatic chains (e.g., miriplatin) (Liu et al, 2016) or using a trans -configuration and positive charge as in the case of BBR3464 and BBR3571 (Billecke et al, 2006; Liu et al, 2006). These changes in platinum(II) complexes ultimately result in variations in size and spatial configurations that affect their permeation, hydrolysis and reactivity rate, as well as impact on cells-resistance mechanisms (Abu-Surrah and Kettunen, 2006).…”

Section: General Considerations On the Physicochemical Properties Of mentioning

confidence: 99%

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Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

et al. 2019

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Cisplatin and other platinum(II) analogs are widely used in clinical practice as anti-cancer drugs for a wide range of tumors. The primary mechanism by which they exert their action is through the formation of adducts with genomic DNA. However, multiple cellular targets by platinum(II) complexes have been described. In particular, the early events occurring at the plasma membrane (PM), i.e., platinum-membrane interactions seem to be involved in the uptake, cytotoxicity and cell-resistance to cisplatin. In fact, PM influences signaling events, and cisplatin-induced changes on membrane organization and fluidity were shown to activate apoptotic pathways. This review critically discusses the sequence of events caused by lipid membrane-platinum interactions, with emphasis on the mechanisms that lead to changes in the biophysical properties of the membranes (e.g., fluidity and permeability), and how these correlate with sensitivity and resistance phenotypes of cells to platinum(II) complexes.

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Section: Innovative Cisplatin-based Therapeutic Strategiesmentioning

confidence: 99%

Section: Innovative Cisplatin-based Therapeutic Strategiesmentioning

confidence: 99%

Section: General Considerations On the Physicochemical Properties Of mentioning

confidence: 99%

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Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

et al. 2019

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“…Zeta potential is another significant parameter in liposome characterisation which is about the total charge of a lipid vesicle attains in a specific medium (Liu et al 2016). Particularly, Zeta potential is an amount of the magnitude of attraction or excretion between particles in lipid vesicles.…”

Section: Zeta Potentialmentioning

confidence: 99%

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Panahi

Farshbaf

Mohammadhosseini

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

195

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Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability; accompanied by their nanosize they have potential applications in nanomedicine, cosmetics, and food industry. Nanoliposome technology offers thrilling chances for food technologists in fields including encapsulation and controlled release of food ingredients, also improved bioavailability and stability of sensitive materials. Amid numerous brilliant new drug and gene delivery systems, liposomes provide an advanced technology to carry active molecules to the specific site of action, and now days, various formulations are in clinical use. In this paper, we provide review of the main physicochemical properties of liposomes, current methods of the manufacturing and introduce some of their usage in food nanotechnology as carrier vehicles of nutrients, enzymes, and food antimicrobials and their applications as drug carriers and gene delivery agents in biomedicine.

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“…Particle size distribution and zeta potential of APN or SAPN were determined as described previously using a ZETA-SIZER Nano-ZS (Malvern Instruments, Ltd., UK) at 25 °C. 19 APN or SAPN stock solution (1 mg/mL corresponding to AP9 or SC-AP9) was diluted at 1:100 with HEPES buffer (0.01M, pH 6.5) before measurement. Each measurement was performed in triplicate.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Nanoparticle Delivery of CD147 Antagonistic Peptide-9 Protects against Acute Ischemic Brain Injury and tPA-Induced Intracerebral Hemorrhage in Mice

Liu

Jin

Wang

et al. 2020

ACS Appl. Bio Mater.

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CD147 has emerged as a potential therapeutic target in many human diseases. We have demonstrated that inhibition of CD147 using its function-blocking antibody ameliorates acute ischemic brain injury and promotes long-term functional recovery in mice. Recently, peptide–nanoparticle conjugates have emerged as powerful tools for biomedical applications. The present study aimed to investigate the therapeutic potential of CD147 antagonist peptide-9 (AP9) in acute ischemic stroke in mice using nanomaterial as the drug delivery vehicles. AP9-conjugated nanoparticles (APN), with an average size of about 40 nm, were fabricated by maleimide linkage and characterized using dynamic light scattering and transmission electron microscopy. We found that APN specifically bound to CD147 in cultured mouse brain endothelial cells (bEnd.3) and to ischemia-induced CD147 in mouse cerebral microvessels. Using a mouse model of transient middle cerebral artery occlusion (tMCAO), we demonstrated, for the first time, that systemic delivery of APN (2.5 mg/kg, I.V.) initiated at 1 h after tMCAO significantly reduced brain infarct size, improved functional outcome, and attenuated delayed (5 h after tMCAO) tPA-induced intracerebral hemorrhage in acute ischemic stroke. These protective effects were associated with profound inhibition of MMP-9 and MMP-3 in both ischemic brain and plasma. In conclusion, the CD147 antagonist peptide-9 represents a potentially promising therapeutic candidate for the treatment of ischemic stroke.

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Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes

Cited by 13 publications

References 25 publications

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity

Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications

Nanoparticle Delivery of CD147 Antagonistic Peptide-9 Protects against Acute Ischemic Brain Injury and tPA-Induced Intracerebral Hemorrhage in Mice

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