Preparation, characterization, and antibacterial effect of doxycycline loaded kefiran nanofibers

Dadashi, Sepideh; Boddohi, Soheil; Soleimani, Neda

doi:10.1016/j.jddst.2019.06.012

Cited by 31 publications

(13 citation statements)

References 42 publications

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“…The grains are capable of producing an exopolysaccharide matrix, known as kefiran, which is much studied today. This polysaccharide has been presented as an excellent alternative for application in some fields such as tissue engineering [8] , regenerative medicine [9] , and drug delivery [10,11] . However, this polysaccharide matrix has also been observed to harbor microorganisms such as bacteria and yeasts [3] .…”

Section: Introductionmentioning

confidence: 99%

Nanoscale morphology, structure and fractal study of kefir microbial films grown in natura

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Nanoscale morphology, structure and fractal study of kefir microbial films grown in natura

et al. 2020

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“…Kefir was supplied from Golestan city. Kefir grains were grown in skim milk at room temperature, and the medium was exchanged daily with new culture medium to maintain grain viability [ 10 ]. After the culture process continued for 7 days, the grains can be considered active.…”

Section: Methodsmentioning

confidence: 99%

Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment

Fatahi

Soleimani

Afrough

2021

International Journal of Food Science

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Kefir drink is one of the most important probiotic products, which is made using kefir microorganisms in fermenting the milk. Numerous investigation have been accomplished in the field of the therapeutic property of probiotic products. In the present study, we assessed the cytotoxic effect of kefir on the rate of growth and increase of glioblastoma cancer cell as the most severe form of brain tumors. In this experimental study, we used a U87 cancer cell line (glioblastoma). The interaction between cancer cells and different concentrations of kefir drink and supernatants at 24 and 48 hours was considered. The cell cytotoxicity of kefir and sedimentation of cell lysate and extract of kefir was assessed using the MTT test after 24 and 48 hours. The result of the MTT test, treatment of the cells with the 48-hour fermented drink, demonstrated the most cell cytotoxicity in comparison with the control group. Results showed that the toxicity effect in all groups was dose-dependent, and by increasing the concentration, cell survival decreased noticeably. The results indicated that the supernatant of fermented kefir drink as a probiotic product has more toxicity and lethality effect on the glioblastoma cancer cell. This product can be utilized as a replacement or a complementary therapy of cancer.

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“…Nanofiber loaded with doxycycline for wound dressing [34] Lactobacillus hilgardii, L. rhamnosus, L. kefir, L. kefiranofascien Antitumor properties [10] L. kefiranofascien Mucosal adjuvant [35] Gellan…”

Section: Bifidobacteriummentioning

confidence: 99%

Biomedical Applications of Bacterial Exopolysaccharides: A Review

et al. 2021

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Bacterial exopolysaccharides (EPSs) are an essential group of compounds secreted by bacteria. These versatile EPSs are utilized individually or in combination with different materials for a broad range of biomedical field functions. The various applications can be explained by the vast number of derivatives with useful properties that can be controlled. This review offers insight on the current research trend of nine commonly used EPSs, their biosynthesis pathways, their characteristics, and the biomedical applications of these relevant bioproducts.

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Preparation, characterization, and antibacterial effect of doxycycline loaded kefiran nanofibers

Cited by 31 publications

References 42 publications

Nanoscale morphology, structure and fractal study of kefir microbial films grown in natura

Nanoscale morphology, structure and fractal study of kefir microbial films grown in natura

Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment

Biomedical Applications of Bacterial Exopolysaccharides: A Review

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