Preparation and study of release kinetics of rosin pentaerythritol ester microcapsules

Sheorey, D. S.; Dorle, A. K.

doi:10.3109/02652049409040434

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…Owing to these, rosin participates in esterification and Diels-Alder cycloaddition reactions. Consequently, researchers have synthesized numerous ester-adduct derivatives of rosin (Mandaogade, Satturwar, Fulzele, Gogte & Dorle, 2002;Pathak & Dorle, 1986;Pathak & Dorle 1987;Pathak, Nikore & Dorle, 1985;Satturwar, Fulzele, et al, 2004;Satturwar et al, 2002;Sheorey and Dorle, 1994). These derivatives exhibited an excellent film-forming ability and could be used as coating and microencapsulating material particularly for sustained drug delivery.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Aqueous and Organic-Based Films and Coatings of PEGylated Rosin Derivative

Morkhade

Nande

Barabde

et al. 2008

Drug Development and Industrial Pharmacy

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Rosin was partially esterified with polyethylene glycol 400 and reacted with maleic-anhydride to form an ester-adduct derivative. Derivative and native rosin were characterized for physicochemical properties. Aqueous coating system of derivative was developed by ammonia neutralization method. Organic-based films were produced using acetone. Aqueous and organic-based films were comparatively evaluated. Derivative exhibited an excellent coat-forming ability on spherical-units. Aqueous-based film exhibited very high water vapor transmission rate, wettability, water uptake, and leaching at pH 6.8. A 20% w/w aqueous-based coat could sustain diclofenac sodium release for 8 h, whereas, 20% w/w organic-based coat released 20.11% of drug in 8 h. In conclusion, aqueous coating system of synthesized rosin derivative can be developed; however, aqueous-coats are less efficient to retard the drug release rate. Instead, the organic-based coatings can efficiently be used for sustained drug delivery.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study of Aqueous and Organic-Based Films and Coatings of PEGylated Rosin Derivative

Morkhade

Nande

Barabde

et al. 2008

Drug Development and Industrial Pharmacy

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“…Rosin esters are reaction products of rosin and polyhydroxyl alcohols such as pentaerythritol and glycerol (Frihart et al 2003). Rosin esters have many commercial applications, including in tackifiers for packaging and in pressure-sensitive adhesives (Anderson 1969), in resins for traffic paints and inks (Baker and Reitnauer 1998;Everhardus et al 2000), in sizing agents for papermaking (Tanaka 1999), emulsifiers for synthetic rubbers, modifiers for rubber (Okita and Yoshida 1973), medicine packaging Dorle 1985, 1986;Sheorey and Dorle 1994), and in cosmetic formulations (Takatsu 1991). Some disadvantages of common rosin esters are their deep color, poor thermal stability, and susceptibility to weathering.…”

Section: Introductionmentioning

confidence: 98%

Synthesis of light-colored rosin glycerol ester

Wang¹

2007

Holzforschung

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A light-colored rosin glycerol ester was synthesized from gum rosin and glycerol in the presence of a highly effective decolorizing agent. The effects of the type and dosage of the decolorizing agent and the reaction temperature and time on the yield, softening point, color, and acid number of the rosin glycerol ester were investigated. Experimental results showed that 4,49-thio-bis(6-tertbutyl-3-methyl phenol) was the best decolorizing agent. It promoted esterification at an optimal dosage of 0.5% (based on the weight percentage of starting material rosin). Suitable conditions for esterification of rosin and glycerol were: reaction temperature, 260-2708C; reaction time, 6-8 h; and rosin/glycerol molar ratio, 2.5:1 (mol mol -1 ). The characteristics of the rosin glycerol ester obtained under these conditions were as follows: softening point, 90-948C (ball and ring method); color, 1-2 (Gardner value); acid number, 7-8; and yield, )88% (based on the total weight of rosin and glycerol). The selected additive has a multifunctional effect involving bleaching, disproportionation, and catalysis.

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“…4 Initially, polyhydric alcohols like glycerol, mannitol, sorbitol, and pentaerythritol have been used to synthesize rosin derivatives. [5][6][7][8] These derivatives showed excellent film properties and could be used successfully to formulate matrix tablets, coated tablets, and microparticles for controlled drug release. However, due to the presence of polyhydric alcohols and complex compositions, it was difficult to understand the precise chemistry and the impact of components of derivatives on their physicochemical and film properties.…”

Section: Introductionmentioning

confidence: 99%

Study of biodegradation and biocompatibility of PEGylated rosin derivatives

Morkhade

Nande

Barabde

et al. 2017

Journal of Bioactive and Compatible Polymers

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PEGylated rosin derivatives are improved in series ester-adduct derivatives of rosin. The aim of this study was to assess biodegradation and biocompatibility of PEGylated rosin derivatives. Study employed two different PEGylated rosin derivatives, namely, D1 and D2, with constant weight of rosin and increasing amounts of polyethylene glycol 400. PEGylated rosin derivatives were synthesized and tailored into spherical beads and disks with smooth surface for use. In vitro degradation was studied at pH 4.0, 7.4, and 10 for 60 days. In vivo study was performed in Wistar rats using poly(d,l-lactide-co-glycolide) (50:50) as a control. Post 3, 7, 14, and 21 days of implantation, PEGylated rosin derivatives disks were retrieved and evaluated for weight loss, molecular weight decline, morphology, and tissue response. D1 and D2 beads showed 21.68% and 32.37% weight loss, respectively, at pH 7.4 post 60 days. Degradation was increased substantially with increase in pH of medium. Degradation of disks was markedly slower than that of beads. In vivo degradation of PEGylated rosin derivative disks was faster than in vitro. Post 60 days of implantation, weight loss of D1 and D2 disk was 7.57% and 11.84%, whereas molecular weight was declined by about 19% and 26%, respectively. Owing to higher amounts of polyethylene glycol 400, in vitro and in vivo degradation of D2 was faster than D1. Poly(d,l-lactide-co-glycolide) as well as PEGylated rosin derivative implants evoked mild inflammatory responses characterized by few macrophages and absence of exudation at tissue–disk interface. The cellular density in tissue surrounding PEGylated rosin derivative disks increased initially with time up to 7 days and decreased eventually at the end of 21 days. The trend was similar for poly(d,l-lactide-co-glycolide) implants. Increase in polyethylene glycol 400 improved biodegradation and biocompatibility of PEGylated rosin derivatives. Results revealed that PEGylated rosin derivatives degrade slowly in vivo over a period of time, possess fair biocompatibility, and thus are promising biomaterial for drug delivery applications.

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Preparation and study of release kinetics of rosin pentaerythritol ester microcapsules

Cited by 9 publications

References 17 publications

A Comparative Study of Aqueous and Organic-Based Films and Coatings of PEGylated Rosin Derivative

A Comparative Study of Aqueous and Organic-Based Films and Coatings of PEGylated Rosin Derivative

Synthesis of light-colored rosin glycerol ester

Study of biodegradation and biocompatibility of PEGylated rosin derivatives

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