A Comparative Study of Aqueous and Organic-Based Films and Coatings of PEGylated Rosin Derivative

Abstract

Rosin was partially esterified with polyethylene glycol 400 and reacted with maleic-anhydride to form an ester-adduct derivative. Derivative and native rosin were characterized for physicochemical properties. Aqueous coating system of derivative was developed by ammonia neutralization method. Organic-based films were produced using acetone. Aqueous and organic-based films were comparatively evaluated. Derivative exhibited an excellent coat-forming ability on spherical-units. Aqueous-based film exhibited very high water vapor transmission rate, wettability, water uptake, and leaching at pH 6.8. A 20% w/w aqueous-based coat could sustain diclofenac sodium release for 8 h, whereas, 20% w/w organic-based coat released 20.11% of drug in 8 h. In conclusion, aqueous coating system of synthesized rosin derivative can be developed; however, aqueous-coats are less efficient to retard the drug release rate. Instead, the organic-based coatings can efficiently be used for sustained drug delivery.

Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

“…The IR spectra of derivatives at 0 hour show C=O stretching ratio at 1690 cm -1 higher than 1721 cm -1 and reduced when the reaction time was increased suggested that the conversion of acid to ester was occurred and increased when increasing reaction time. This is consistent with the previous study [14]. These results suggest that ester group presented in all kinds of rosin-PEG derivatives.…”

“…From this result it can suggest than melting point of derivative was affected from rosin content and melting point of PEG. This result shows consistent with previous study [4], [14], [19]. C-NMR spectra of rosin-PEG 1500 derivatives.…”

Effects of plasticizers and surfactants on the film forming properties of hydroxypropyl methylcellulose for the coating of diclofenac sodium tablets

“…In vitro release studies (Morkhade et al, 2008;Fulzele et al, 2002;Ghosh et al, 2007) The release measurements were performed using 8 stage USP dissolution apparatus-1 (Disso-2000, Lab India). The dissolution parameters (one tablet; 37 ± 0.5°C; 100 rpm; 900 ml of 0.1(N) hydrochloric acid).…”

“…Our present study is aimed in the preparation of a 25 mg DFS tablet and subsequent development of an optimized film coating formula after properly studying the effects of plasticizer and surfactants for the purpose of coating the tablets (Motola et al, 2001;Morkhade et al, 2008).…”

Investigation of the effects of curing and casting methods on the physicochemical properties of polymeric coating systems

“…The effect of curing time and temperature on the glass transition temperatures of SR30D films is illustrated in Figure 3 such as acid groups [22,23], ionic concentration [24,25], category of counter ion [26][27][28][29], plasticizers [30][31][32] and thermal treatment [25,[33][34][35][36]. Dynamic mechanical analysis After curing at 60°C for 4 hours, there were two endothermic peaks.…”