Preparation and structure of drug-carrying biodegradable microspheres designed for transarterial chemoembolization therapy

Abstract

Biodegradable poly(D,L-lactic acid) drug-eluting microspheres containing anti-tumor drugs, cisplatin, and sorafenib tosylate have been prepared by the emulsion solvent evaporation method with diameter between 200 and 400 μm. Scanning electron microscopy showed that cisplatin microspheres had smooth surfaces, while sorafenib tosylate microspheres and cisplatin + sorafenib tosylate microspheres were porous at the surface and the pits of the latter were larger than those of the former. Notably, cisplatin + sorafenib tosylate microspheres had a fast drug release rate compared with microspheres containing one drug alone. In vitro cytotoxicity experiments and classical matrigel endothelial tube assay certificated the maintaining bioactivity of cisplatin and sorafenib tosylate released from the microspheres, respectively. This work provides a useful approach for the fabrication of drug-eluting beads used in transarterial chemoembolization.

The studies about doxorubicin-loaded p(N-isopropyl-acrylamide-co-butyl methylacrylate) temperature-sensitive nanogel dispersions on the application in TACE therapies for rabbit VX2 liver tumor

“…Especially as combined TAC and TAE, TACE could block tumor blood-vessel and cause tumor necrosis via combined injection of chemotherapeutic and embolizing agents. Therefore, it has become the most widely used treatment for unresectable liver cancer due to its higher efficacy and safeness than other therapies to liver cancer [10,11].…”

Poly(lactide-co-glycolide) microspheres for MRI-monitored delivery of sorafenib in a rabbit VX2 model

“…Poly(lactide- co -glycolide) (PLG) is a biodegradable polymer already used in FDA approved devices such as Lupron Depot® and in POLYSORB ™ sutures. Previous studies have validated the potential to fabricate PLG microspheres for TACE procedures [20–22]. The advantageous drug loading mechanism for PLG platforms involves encapsulating the drug during the fabrication process [23].…”

Effect of Inhibiting Tumor Angiogenesis After Embolization in the Treatment of HCC with Apatinib-Loaded p(N-Isopropyl-Acrylamide-co-Butyl Methyl Acrylate) Temperature-Sensitive Nanogel

“…[54][55][56] At present, research on interventional embolization materials for HCC mainly focuses on the preparation of drug-eluting microspheres. 57,58 Although drug-eluting microspheres transarterial chemoembolization shows a specific slowrelease effect, it does not last long. The drug in the liver decreased to minimal levels (less than 10 ng/mL) within 2 weeks to 1 month after the operation.…”