Preparation and Reactions of 1-Cyanoformimidic Acid Hydrazide

Microwave-Assisted Preparations of Amidrazones and Amidoximes

“…Reactions of nitriles with hydrazines [Scheme , (i)] is frequently used for the preparation of amidrazones, ,− but the outcome depends on the nature of the nitrile, and further reaction can give dihydrotetrazines and subsequently tetrazines ) for the synthesis of amidrazones avoid the use of nitriles by reaction of hydrazine with (ii) imidates or their salts (X = O, S; R 2 = Alk), 8a,b (iii) imidoyl halides, , (iv) amides and thioamides in the presence of POCl 3 , ,10a,b (v) dihydroxathiazoledioxides, or (vi) ketenimines (R, R 1 = Ar) .…”

Chemistry of amidrazones

“…The earlier work in this part of the field has been reviewed;17 however, this aspect has again been the subject of renewed interest, and more recently the cyanoformamidrazone (19) has been isolated in good yield from the interaction of the reagents cyanogen and hydrazine (1:1) in dioxane-methanol at 5°. 18,19 yNNH2 (CN)2 + NH2NH2 -> NCC(f xNH2…”

Expanding the chemical space of 3(5)-functionalized 1,2,4-triazoles

“…5-Methyl-1 H -1,2,4-triazole-3-carbonitrile (32b) was synthesized from compound 21b (630 mg). Yield 27 mg (5%), white solid, mp 132–133°C (mp 135–136°C (PhMe) 63 ). 1 H NMR spectrum (500 MHz, DMSO- d 6 ), δ, ppm: 14.76 (1H, br.…”