Expanding the chemical space of 3(5)-functionalized 1,2,4-triazoles

Crystal structure and Hirshfeld-surface analysis of diaquabis(5-methyl-1H-1,2,4-triazole-3-carboxylato)copper(II)

“…Generally, compounds containing a carboxylic function are probably the most important materials for high-throughput synthesis and 1,2,4-triazoles are not an exception. Recently, as part of our efforts to prepare new synthesis building blocks, we obtained a series of carboxylic acids and their derivatives (Khomenko et al, 2022). One of those compounds was used to synthesize a copper complex.…”

“…H 2 L: LiHL (Khomenko et al, 2022) (1.33 g, 10 mmol) was dissolved in H 2 O (10 ml). The obtained solution was cooled and slowly acidified with concentrated HCl (1 ml), maintaining the temperature between 273 and 278 K. The precipitation of colourless crystals occurred after addition of all the HCl.…”

Synthesis and crystal structure of N 1,N 2-dimethylethanedihydrazide

“…Currently, there is significant research interest in developing new methods for their synthesis, focusing on efficient and atom-economical routes (Favi, 2020;Pathan et al, 2020). Among these novel synthetic approaches, the utilization of hydrazides stands out as one of the most appealing methods for synthesizing heterocyclic compounds such as pyrazoles, triazoles, oxadiazoles and pyridazines (Majumdar et al, 2014;Mittersteiner et al, 2021;Hosseini & Bayat, 2018;Khomenko et al, 2022).…”

Solvent- and functional-group-assisted tautomerism of 3-alkyl substituted 5-(2-pyridyl)-1,2,4-triazoles in DMSO–water

“…1,2,4-Triazoles have attracted great interest due to their applications in fields such as organic synthesis, 1 coordination chemistry, 2 materials sciences, 3 agriculture 4 and pharmaceutical medicine. 5 As medicinal products, they are characterised by a broad therapeutic range including antibacterial, 6 antifungal, 7 anticancer, 8 antinematode, 9 and anticonvulsant 10 activities and have shown considerable potential for the treatment of neglected diseases.…”