Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy

Cao, Junpeng; Wang, Yongxian; Yu, Jiahui; Xia, Jiaoyun; Zhang, Chunfu; Yin, Duanzhi; Häfeli, Urs O.

doi:10.1016/j.jmmm.2003.10.022

Cited by 139 publications

(43 citation statements)

References 27 publications

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“…Magnetic nanoparticles offer great potential applications in a variety of biomedical fields, such as improved contrast agents for magnetic resonance imaging (MRI) [1], cell separation [2], hyperthermia tumor treatment [3] and as magnetic field-guided carriers for localizing drugs or radioactive therapies [4]. Superparamagnetic CoFe 2 O 4 nanoparticles are considered as promising materials for above biomedical application, due to high magnetocrystalline anisotropy, moderate saturation magnetization, high chemical stability and high biocompatibility [5,6].…”

Section: Introductionmentioning

confidence: 99%

Salt-assisted combustion synthesis of highly dispersed superparamagnetic CoFe2O4 nanoparticles

Zhang¹,

Jiang²,

Duan³

et al. 2009

Journal of Alloys and Compounds

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Section: Introductionmentioning

confidence: 99%

Salt-assisted combustion synthesis of highly dispersed superparamagnetic CoFe2O4 nanoparticles

Zhang¹,

Jiang²,

Duan³

et al. 2009

Journal of Alloys and Compounds

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“…Magnetic particles are currently used for magnetic separation, to collect tagged cells or DNA sequences, [1][2][3] and for magnetically guided drug delivery. [4][5][6] A key advantage of magnetism lies in the ability to control motion at a distance without perturbing the biological system, as would occur with a large electric field. Noble-metal nanostructures are beneficial not only because of their relative ease of biofunctionalization, but also for plasmonic biosensing.…”

mentioning

confidence: 99%

Synthesis and Single‐Particle Optical Detection of Low‐Polydispersity Plasmonic‐Superparamagnetic Nanoparticles

et al. 2008

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Both magnetic and plasmonic particles are of increasing interest for biomedical applications. Magnetic particles are currently used for magnetic separation, to collect tagged cells or DNA sequences, [1][2][3] and for magnetically guided drug delivery. [4][5][6] A key advantage of magnetism lies in the ability to control motion at a distance without perturbing the biological system, as would occur with a large electric field. Noble-metal nanostructures are beneficial not only because of their relative ease of biofunctionalization, but also for plasmonic biosensing. [7][8][9][10] Unlike quantum dots, [11] these particles do not show optical bistability or blinking making them competitive with fluorophores for quantifying the number of cell surface markers. [12,13] The main advantages of plasmonic particles are their extremely large molar extinction coefficients and resonant Rayleigh scattering efficiencies, [8] and the exceptional sensitivity of the surface plasmon resonance peak wavelength to changes in the local dielectric environment. Individual plasmonic nanoparticles and nanorods have been detected by using dark field optical microscopy. [13][14][15][16][17] In fact, by using nonmagnetically responsive gold-coated silica particles ($150 nm), Halas and co-workers have demonstrated the capability of gold-shell nanoparticles in detecting low concentrations of analytes in whole blood within minutes without any sample preparation.[18]Here we describe the preparation of iron oxide/gold core/ shell nanoparticles that can be moved magnetically and imaged optically. The synthesis of large-diameter ($150 nm) magnetic plasmonic three-layer composite particles has previously been reported, [19] but our focus here is on smaller particles. The small size of these nanoparticles approaches that of cellmembrane-bound antigens, and is in a range in which particles can be spontaneously internalized by endocytosis. We expect that the combination of magnetic responsiveness, facile bioconjugation, and a localized surface plasmon resonance in these smaller nanoparticles will open new possibilities for in vitro molecular and cell biological applications, including intracellular mechanical and chemical composition analyses, and magnetophoretic cell sorting according to the expression level of cell surface receptors. The magnetic forcẽ F m ¼ ðm pt Á rÞB * that can be applied to a particle depends on the particle magnetic moment m pt . Since m pt ¼ M s V pt , where M s is the saturation magnetization of the material and V pt is the particle volume, a larger size is generally preferable for a strong magnetic response. Thus there is a compromise between large magnetic moments and the desirability of small sizes for new applications.Gold, silver, and SiO 2 core/Au shell particles have been used for plasmonic sensing, where the surface plasmon peak wavelength shifts in response to small changes in the dielectric environment near the particle surface. A core/shell structure with the noble metal in the shell enables the surface plasmon resona...

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“…[183] A modification of the magnetically guided drug delivery is the use of composite magnetic particles with radionuclides. [184] Most magnetic separation strategies use the composite magnetic particles in solution with mixtures of biological species. [185][186][187] After selective reaction is allowed to occur, the bound species are separated magnetically.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…The advantage of this approach is that drug side-effects could be minimized, since the drug would not be distributed throughout the body. Anticancer treatments are now being tested using attached radioisotopes, [184] and chemotherapy drugs. [189] One type uses hyperthermia to release the drug from a hydrogel surrounding the particles.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Magnetic Nanoparticles and Their Applications

Majetich

2007

Nanostructured Materials

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Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy

Cited by 139 publications

References 27 publications

Salt-assisted combustion synthesis of highly dispersed superparamagnetic CoFe2O4 nanoparticles

Salt-assisted combustion synthesis of highly dispersed superparamagnetic CoFe2O4 nanoparticles

Synthesis and Single‐Particle Optical Detection of Low‐Polydispersity Plasmonic‐Superparamagnetic Nanoparticles

Magnetic Nanoparticles and Their Applications

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