Preparation and properties of triethyl citrate plasticized chitosan‐based membranes for efficient release of curcumin

Li, Huo; Wei, Yuru; Zhang, Haixia; Wang, Ying; Deng, Bo; Wang, Yaxiong; Jin, Lisheng

doi:10.1002/app.51908

Cited by 5 publications

(3 citation statements)

References 46 publications

(38 reference statements)

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“…When the amount of EC and TEC increased, folding endurance that was positively correlated increased. Because of the high polymer matrix and plasticizer, EC and TEC might also make the film more flexible [23]. According to another report, adding more plasticizers to a plasticized polymer system decreased the force needed to break the films and the resistance to deformation because the presence of plasticizers reduced the interaction between polymer chains [24].…”

Section: Resultsmentioning

confidence: 99%

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Monton

Suksaeree

2023

Trends Sci

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With the guidance of Design-Expert® software version 11, the mechanical properties of topical films containing Ganoderma applanatum (G. applanatum) extracts were investigated. While ethyl cellulose (EC), G. applanatum extracts, and triethyl citrate (TEC) were independent factors, ultimate tensile strength (UTS), elongation at break, and folding endurance were dependent variables. The best relationships between UTS, elongation at break, and folding endurance could be predicted more accurately using quadratic, 2FI, and linear models, respectively. The ratio of EC, G. applanatum extracts, and TEC was predicted by the Design of Experiments (DoE) to be 2.6: 2.8: 2.8. The model’s suitability for predicting outcomes inside the design space without necessitating extra trials was established by proving that the ratio’s value of prediction was more than 4. The experimental values of UTS, elongation at break, and folding endurance were 82.15±7.42 MPa, 87.40±15.56 %, and 79±6 folds, respectively. The percent errors of prediction were 12.27, 15.49, and 11.82 %, respectively. The Design-Expert® software’s DoE effectively demonstrated a low percent error of the prediction of less than 20 %. This was suitable and acceptable for developing film formulation in drug delivery systems. HIGHLIGHTS The formulations of topical films containing applanatum extract were optimized, and they were improved EC and TEC were used as polymer matrix and plasticizer, respectively The best relationships between UTS, elongation at break, and folding endurance could be predicted more accurately using quadratic, 2FI, and linear models, respectively UTS, elongation at break, and folding endurance experimental values were 82.15±7.42 MPa, 87.40±15.56 %, and 79±6 folds Less than 20 % was effectively proven which was enough and acceptable GRAPHICAL ABSTRACT

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Section: Resultsmentioning

confidence: 99%

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Monton

Suksaeree

2023

Trends Sci

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“…Although no definitive evidence of health risks associated with DBDA and BehD exists, this study revealed the extensive presence of these plasticizers in plastic-bottle-packaged PCPs, which could raise attention on potential human exposure through consumption. TEC is used as a plasticizer in the formation of membranes . It is also a food additive used to stabilize foams, especially to improve the whipping properties of egg whites .…”

Section: Resultsmentioning

confidence: 99%

“…TEC is used as a plasticizer in the formation of membranes. 51 It is also a food additive used to stabilize foams, especially to improve the whipping properties of egg whites. 52 In this study, TEC was detected in 90% of the SH samples and 100% of the HC samples, contributing to the highest mean peak areas of 1.24 × 10 08 and 3.00 × 10 08 among all classifications, respectively.…”

Section: Journal Of Thementioning

confidence: 99%

Target and Suspect Screening for Organic Additives in Six Classifications of Personal Care Products Using Liquid Chromatography–High-Resolution Mass Spectrometry

Shen,

Kang,

Choi

et al. 2024

J. Am. Soc. Mass Spectrom.

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Personal care products (PCPs) are integral components of daily human existence, including a large number of chemicals intentionally added for functional attributes (e.g., preservatives and fragrances) or unintentionally present, such as plasticizers. This investigation aimed to optimize the methodology for target and suspect screening via liquid chromatography− high-resolution mass spectrometry, focusing on nine prevalent organic additives (comprising bisphenols A, F, and S, methyl, ethyl, propyl, and butylparaben, 5-chloro-2-methyl-4-isothiazolin-3-one, and 4-hydroxybenzoic acid). A total of 50 high-selling PCPs were purchased from the local online market as samples. In detail, PCP samples were classified into body washes, shampoos, hair conditioners, facial cleansers, body lotions, and moisture creams. For calibration, the quality assurance and quality control results demonstrated a coefficient of determination (R 2 ) surpassing 0.999, with detection and quantification limits ranging from 2.5 to 100.0 ng/g. For recovery experiments, replicate recoveries (n = 5) ranged from 61 to 134%. In purchased PCP samples, five of the nine target compounds were detected via a target screening. Methylparaben exhibited the highest concentration (7860 mg/kg) in a facial cleanser, which is known as an endocrine-disrupting chemical. A total of 248 suspects of organic additives were screened in PCPs, leading to a tentative identification of 9. Confirmation (confidence level 1) via reference standards was achieved for three suspects, while six were tentatively identified with a confidence level of 2. This two-step extraction methodology utilizing methyl tert-butyl ether and isopropyl alcohol enabled simultaneous analysis of diverse chemical groups with distinct properties.

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Preparation and evaluation of antioxidant activity of citric acid-polyethylene glycol-tannin elastomers

Wang,

Huo,

Jia

et al. 2023

Colloid Polym Sci

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Preparation and properties of triethyl citrate plasticized chitosan‐based membranes for efficient release of curcumin

Cited by 5 publications

References 46 publications

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Target and Suspect Screening for Organic Additives in Six Classifications of Personal Care Products Using Liquid Chromatography–High-Resolution Mass Spectrometry

Preparation and evaluation of antioxidant activity of citric acid-polyethylene glycol-tannin elastomers

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