Preparation and Properties of Novel pH-Sensitive Soy Protein/Poly(sodium acrylate) Interpenetrating Polymer Network Hydrogels

J of Applied Polymer Sci

2011

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A series of the thermosensitive interpenetrating polymer network hydrogels composed of soy protein and poly(N-isopropylacrylamide) were successfully prepared. The structure and properties were systematically characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and differential scanning calorimetry. It was found that the hydrogels had good miscibility and high porosity, and the volume phase transition temperatures of the hydrogels were around 32 C. The release behavior and the release mechanism of a model protein, bovine serum albumin (BSA), were also investigated in detail. The results indicated that the release behavior of BSA had strong temperature dependence and the release percentage of BSA could be controlled by modulating the amount of soy protein or crosslinking agent. The analysis of the release mechanism revealed that the Fickian diffusion controlled release was dominant under the experimental conditions. V C 2011 Wiley Periodicals, Inc. J Appl Polym Sci 120: [3613][3614][3615][3616][3617][3618][3619][3620] 2011

Section: Resultsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Thermosensitive soy protein/poly(n‐isopropylacrylamide) interpenetrating polymer network hydrogels for drug controlled release

J of Applied Polymer Sci

2011

Self Cite

“…The ESRs are low in the pH range from 1.2 to 4.0, but high when pH > 4.0. Soy protein has high glutamic acid (11.9%) and aspartic acid (20.5%) contents and its isoelectric point is near pH 4.5, and the p K a of PAA is ca. 4.8.…”

Section: Resultsmentioning

confidence: 99%

“…Poly( N ‐isopropylacrylamide) (PNIPAAm) is a well‐known temperature‐responsive polymer with a volume phase transition temperature (VPTT) of ∼32°C in aqueous solution, whereas poly(acrylic acid) (PAA) is a typical pH‐responsive polymer . Both the polymers have been widely studied in biomedical field because of their responses to external stimuli .…”

Section: Introductionmentioning

confidence: 99%

pH‐ and temperature‐responsive IPN hydrogels based on soy protein and poly(N‐isopropylacrylamide‐co‐sodium acrylate)

J of Applied Polymer Sci

Liao

2013

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pH‐ and temperature‐responsive interpenetrating polymer network (IPN) hydrogels based on soy protein and poly(N‐isopropylacrylamide‐co‐sodium acrylate) were successfully prepared. The structure and properties of the hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry, and thermogravimetric analyzer. The equilibrium and dynamic swelling/deswelling behaviors and the drug release properties of the hydrogels responding to pH and/or temperature were also studied in detail. The hydrogels have the porous honeycomb structures, good miscibility and thermal stability, and good pH‐ and temperature‐responsivity. The volume phase transition temperature of the hydrogels is ca. 40°C. Changing the soy protein or crosslinker content could be used to control the swelling behavior and water retention, and the hydrogels have the fastest deswelling rate in pH 1.2 buffer solutions at 45°C. Bovine serum albumin release from the hydrogels has the good pH and temperature dependence. The results show that the proposed IPN hydrogels may have potential applications in the field of biomedical materials such as in drug delivery systems. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39781.

“…1 Increasing interest in a new class of materials based on blends of natural and synthetic polymers has been observed during the last three decades, 2-4 as the blends have the advantages of both natural and synthetic polymers. In recent years, natural polymers due to their renewability, biodegradability and biocompatibility have attracted great interest in blending with stimuli-responsive polymers for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation and properties of fast temperature-responsive soy protein/PNIPAAm IPN hydrogels

et al. 2014

JSCS

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The interpenetrating polymer network of fast temperature-responsive hydrogels based on soy protein and poly(N-isopropylacrylamide) were successfully prepared using sodium bicarbonate (NaHCO 3 ) solutions as the reaction medium. The structure and properties of the hydrogels were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, differential scanning calorimetry and thermal gravimetric analysis. The swelling and deswelling kinetics were also investigated in detail. The results showed that the proposed hydrogels had a highly porous structure, good miscibility and thermal stability, and a fast temperature response. The presence of NaHCO 3 had little effect on the volume phase transition temperature (VPTT) of the hydrogels, and the VPTTs were at about 32 °C. Compared with the traditional hydrogels, the proposed hydrogels had much faster swelling and deswelling rates. The swelling mechanism of the hydrogels was non-Fickian diffusion. These fast temperature-responsive hydrogels may have potential applications in the field of biomedical materials.