pH‐ and temperature‐responsive IPN hydrogels based on soy protein and poly(<i>N</i>‐isopropylacrylamide‐<i>co</i>‐sodium acrylate)

Liu, Yong; Cui, Yaodong; Liao, Miaochan

doi:10.1002/app.39781

Cited by 9 publications

(3 citation statements)

References 45 publications

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“…Blends have many applications, but in particular they are being proposed for using in drug delivery based on polymers [2][3][4] ; or on composites [5] . pH-sensitive systems are a particular case and several materials were proposed for preparing them, including silica particles [6,7] , other inorganic particles [8] , polymeric blends [9][10][11][12] , copolymers [13][14][15] and hybrid materials [16,17] .…”

Section: Introductionmentioning

confidence: 99%

Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Echeverría¹,

Pardini²,

Debandi

et al. 2015

Polímeros

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SbstractA pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film-forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.

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Section: Introductionmentioning

confidence: 99%

Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Echeverría¹,

Pardini²,

Debandi

et al. 2015

Polímeros

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“…These changes indicated the presence of the electrostatic interaction between the amine groups of CS (NH 3 + ) and the carboxyl groups of 7S (COO − ) . Additionally, compared with 7S (band at 3413 cm −1 ) and CS (band at 3425 cm −1 ), the OH stretching vibration band of 7S–CS shifted to a low wave number (band at 3374 cm −1 ); this indicated that intermolecular hydrogen bonds were also involved in the nanoparticles …”

Section: Resultsmentioning

confidence: 98%

Nanoparticles based on β‐conglycinin and chitosan: Self‐assembly, characterization, and drug delivery

Liu

Liang

Wei

et al. 2015

J of Applied Polymer Sci

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The purpose of this study was to fabricate and evaluate nanoparticles based on β‐conglycinin (7S) and chitosan (CS) to deliver 5‐fluorouracil (5‐FU). The nanoparticles were prepared with a self‐assembly method. Turbidity measurements performed at 600 nm were used to investigate the formation of the nanoparticles as a function of the pH, 7S‐to‐CS mass ratio, and total concentration of 7S and CS. The optimum conditions for the preparation of the nanoparticles were a pH of 5.5, a 7S‐to‐CS mass ratio of 4 : 1, and total concentration of 7S and CS of 9 mg/mL. Under these conditions, the nanoparticles in solution had a high turbidity and good stability. Fourier transform infrared spectroscopy revealed that the nanoparticles were formed mainly through electrostatic interactions between the amine groups (NH3+) of CS and the carboxyl groups (COO−) of 7S. Scanning electron microscopy micrographs and dynamic light scattering analysis showed that the nanoparticles had an approximately spherical morphology with a smooth surface, and the mean particle size was about 120 nm with a narrow size distribution. The release of 5‐FU showed an initial burst release followed by a sustained release, and the release was pH‐dependent. The release mechanism of 5‐FU was Fickian diffusion according to the Ritger–Peppas model. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41963.

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“…An overview has been reported on developed cold‐set soy protein hydrogels for pH‐dependent controlled release of riboflavin . Similarly, pH‐responsive soy protein and poly[( N ‐isopropylacrylamide)‐ co ‐(sodium acrylate)]‐based interpenetrating polymer network hydrogels crosslinked with glutaraldehyde have been fabricated for potential applications in drug delivery . Swelling studies of the hydrogels were also conducted under different pH conditions.…”

Section: Introductionmentioning

confidence: 99%

Size‐controlled preparation of nanosoy for potential biomedical applications

Singh

Gupta

2016

Polymer International

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Soy protein isolate nanoparticles (nanosoy) have significant applications in drug delivery, wound care systems and tissue engineering. We report an optimum technique named nanoprecipitation which enabled one-step formation of near-monodisperse nanosoy based on solvent displacement. Excellent control over protein aggregation was achieved, producing nanoparticles in the size range of 5-15 nm. The effect of various process parameters such as temperature, solvent/non-solvent ratio, crosslinker content and type of surfactant on the particle size was investigated. The structural and morphological features were analysed using dynamic light scattering, X-ray diffraction and high-resolution transmission electron microscopy. The morphological examination indicated that the particles formed were spherical in shape and further reduction in the average particle diameter was achieved by reducing the temperature and solvent/non-solvent ratio of the reaction medium. Surface charge and stability of nanosoy dispersions were analysed using zeta potential measurements. Further, ciprofloxacin release was monitored using nanosoy as a drug carrier. This technique provides an effective and straightforward approach offering considerable advantages in terms of economic, technical and environmental performance.

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pH‐ and temperature‐responsive IPN hydrogels based on soy protein and poly(N‐isopropylacrylamide‐co‐sodium acrylate)

Cited by 9 publications

References 45 publications

Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Nanoparticles based on β‐conglycinin and chitosan: Self‐assembly, characterization, and drug delivery

Size‐controlled preparation of nanosoy for potential biomedical applications

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