Preparation and properties of nano-amorphous organic and inorganic particles via chemical and mechanochemical routes

Senna, Mamoru; Nakayama, Shinobu

doi:10.1016/j.jallcom.2008.09.212

Cited by 19 publications

(7 citation statements)

References 41 publications

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“…For example Shi et al [1] have studied the structural evaluation of mechanically alloyed nanocrystalline FeAl intermetallics, Zakeri et al [2] have synthesized Bi 2 Te 3 nanocrystalline materials by using mechanical alloying, Rafea et al [3] have studied the structural and optical properties of nanosized Zn 0.5 Cd 0.5 S thin films prepared by dip-coating methods, Yang et al [4] have performed controlled synthesis and characterization of ZnSe nanostructures by using solvothermal approach in a mixed solution, Tripathi et al [5] have studied the optical properties of Se-Te nanostructured thin films grown by thermal evaporation, and Kotkata et al [6] have synthesized CdS nanoparticles. The work on temperature and capping dependence of NIR emission from PbS nanomicrocrystallites with different morphologies by Pendyala and Rao [7], synthesis of Ag 2 S and Ag 2 Se nanoparticles in self-assembled block copolymer micelles and nanoarrays fabrication by Anthony [8], characterization of Bi 2 S 3 nanorods and nanostructured flowers prepared by hydrothermal methods by Phuruangrat et al [9], synthesis of nano-Cd x Zn 1−x S by precipitate-hydrothermal methods and their photocatalytic activities by Zu et al [10], preparation and properties of nanoamorphous organic and in-organic particles by Senna and Nakayama [11], influence of heat treatment and gamma rays irradiation on the structural and optical characterization of nanocrystalline cobalt phthalocyanine thin films by El-Nahass et al [12], fabrication of nanocrystalline silicon thin film at low temperature by using a neutral beam deposition method by Kang et al [13], and analysis of amorphous-nano crystalline multilayer structures by optical, photodeflection, and photocurrent spectroscopy by Gracin et al [14] are also worth mentioning.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Se₃₅Te_65−xGe_x Nanoparticle Films and Their Optical Properties

Salah

Habib

Khan

et al. 2012

Journal of Nanomaterials

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Thin films of () nanoparticles were synthesized using thermal evaporation method. They were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), and absorption and transmission spectra. XRD results show that these films are of amorphous nature, while SEM images show nanoparticles with average particle size around 30 nm. No significant changes are observed in morphology of the deposited films by changing concentrations of Te and Ge. The optical behaviors of these films have been studied using the absorption and transmission spectra in the spectral region 400–1100 nm. The absorption, extinction coefficients and refractive index were obtained and investigated in more detail. The optical band gap () values were also determined and are found to decrease from 0.83 to 0.69 eV by increasing the concentration of Ge from 0 to 12. The transmission spectra for the thin films of nanoparticles show strong absorption at wavelength less than 500 nm and become highly transparent at wavelength above 800 nm. No significant changes in the transmission spectra are observed by increasing concentration of Ge. These results might be useful for development of optical disks and other semiconducting devices based on these nanochalcogenides.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Se₃₅Te_65−xGe_x Nanoparticle Films and Their Optical Properties

Salah

Habib

Khan

et al. 2012

Journal of Nanomaterials

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“…Nanoparticles improve dissolution rate and bioavailability of poorly water-soluble drugs [38][39][40][41] owing to increased surface area available for dissolution as described by the Noyes-Whitney equation [42]. The co-grinding technique has already been employed for amorphization of drugs [43,44]. A two-fold enhancement of the extent of meloxicam dissolution was observed in the case of the meloxicam PEG 6000 co-ground product, in which meloxicam is in nanocrystal form.…”

Section: Resultsmentioning

confidence: 99%

Study of the parameters influencing the co-grinding process for the production of meloxicam nanoparticles

et al. 2011

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Co-grinding is a procedure for the preparation of nanoparticles in which the drug is ground together with one or more excipients. The grinding of meloxicam, a crystalline solid, together with amorphous polyvinylpyrrolidone (PVP) or semi-crystalline polyethylene glycol (PEG) as excipients, is expected to lead to a drastic reduction in particle size. We optimized meloxicam grinding using a three level full factorial response surface design. In the case of PVP the optimum co-grinding parameter set in our study proved to be a meloxicam to PVP-C30 ratio of 1:1, and a rotation frequency of 400 rpm. The best size reduction was achieved at a meloxicam to PEG 6000 ratio = 1:2 at a rotation frequency of 400 rpm: nanoparticles averaging d SEM = 174 nm in diameter and with a very narrow size distribution (standard deviation 35% of mean) were obtained. X-ray powder diffraction analysis indicated that the optimized products contained amorphous meloxicam nanoparticles in the PVP-C30 composition, although meloxicam nanocrystals could also be detected in the samples which contained PEG 6000. The dissolution properties were significantly increased under nasal conditions (pH 5.1, temperature 30°C), especially in the case of the amorphous product. Such dry powder systems can offer novel opportunities in systemic nasal drug delivery.

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“…The interactions between drug and polymer on a nanostructured system can promote greater difficulty in dissolving AmpB, and just as the physical formulation of the state, crystalline or amorphous, also play an important role in controlling the release of the drug (Essa et al, 2010;Freire et al, 2017). Amphotericin B has a crystalline structure, which contributes to their poor solubility (Senna and Nakayama, 2009). For this reason, the intensity of the diffraction peaks becomes slightly more pronounced, when amphotericin was incorporated into the nanofibers.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species

Gonçalves

Rocha

Pires

et al. 2020

Front. Bioeng. Biotechnol.

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The aim of this study was to develop polymeric nanofibers for controlled administration of Amphotericin B (AmpB), using the solution centrifugation technique, characterizing its microstructural and physical properties, release rate, and activity against Leishmania and Candida species. The core-shell nanofibers incorporated with AmpB were synthesized by Solution Blow Spinning (SBS) and characterized by scanning electron microscopy (SEM), differential scanning calorimetry, X-Ray diffraction, and drug release assay. In vitro leishmanicidal and antifungal activity were also evaluated. Fibrous membranes with uniform morphology and smooth surfaces were produced. The intensity of the diffraction peaks becomes slightly more pronounced, assuming the increased crystallization in PLA/PEG at high AmpB loadings. Drug release occurred and the solutions with nanofibers to encourage greater incorporation of AmpB showed a higher concentration. In the results of the experiment with promastigotes, the wells treated with nanofibers containing concentrations of AmpB at 0.25, 0.5, and 1%, did not have any viable cells, similar to the positive control. Various concentrations of AmpB improved the inhibition of fungal growth. The delivery system based on PLA/PEG nanofibers was properly developed for AmpB, presenting a controlled release and a successful encapsulation, as well as antifungal and antileishmanial activity.

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Preparation and properties of nano-amorphous organic and inorganic particles via chemical and mechanochemical routes

Cited by 19 publications

References 41 publications

Synthesis and Characterization of Se₃₅Te_65−xGe_x Nanoparticle Films and Their Optical Properties

Synthesis and Characterization of Se₃₅Te_65−xGe_x Nanoparticle Films and Their Optical Properties

Study of the parameters influencing the co-grinding process for the production of meloxicam nanoparticles

Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species

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Preparation and properties of nano-amorphous organic and inorganic particles via chemical and mechanochemical routes

Cited by 19 publications

References 41 publications

Synthesis and Characterization of Se35Te65−xGex Nanoparticle Films and Their Optical Properties

Synthesis and Characterization of Se35Te65−xGex Nanoparticle Films and Their Optical Properties

Study of the parameters influencing the co-grinding process for the production of meloxicam nanoparticles

Effectiveness of Core-Shell Nanofibers Incorporating Amphotericin B by Solution Blow Spinning Against Leishmania and Candida Species

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Synthesis and Characterization of Se₃₅Te_65−xGe_x Nanoparticle Films and Their Optical Properties

Synthesis and Characterization of Se₃₅Te_65−xGe_x Nanoparticle Films and Their Optical Properties