Preparation and properties of morphology controlled poly(2-hydroxyethyl methacrylate)/poly(N-vinyl pyrrolidone) double networks for biomedical use

Tang, Qingfeng; Yu, Junrong; Chen, Lei; Zhu, Jing; Hu, Zuming

doi:10.1016/j.cap.2009.09.012

Cited by 17 publications

(15 citation statements)

References 21 publications

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“…37 The use of PVP opens additional opportunities for the synthesis and stabilization of metal nanopowders, modification of various substances and materials, improvement of modern technologies, production of new functional materials, and the respective expansion of their fields of use. [38][39][40][41][42] Preliminary research has established the prospects for the use of materials based on pHEMA-gr-PVP copolymers [43][44][45][46][47][48] in the biomedical field, which is possible due to their high sorption capacity, elasticity, stability of form in solvents, and biotolerance. These characteristics make it possible to saturate pHEMA-gr-PVP copolymers with medicinal plant extracts and obtain materials that can be used for prolonged enrichment of the skin with biologically active components.…”

Section: Introductionmentioning

confidence: 99%

Improving the Long-Term Performance of Poly(Vinyl Chloride)

Brostow¹,

Fałtynowicz²,

Hnatchuk³

et al. 2022

ChChT

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Since neat PVC is rigid, in all applications a plasticizer is added. Migration of the plasticizer results in brittleness of flexible PVC and environmental pollution. We have used three types of cross-linking agent blended with commercial PVC, plasticizer and thermal stabilizer. Heat treatments at 100С, 121С and 136C were performed. We made tensile tests, dynamic friction tests, wear rate determination, scratch resistance determination, water absorption tests and SEM analysis – to make selection of compositions suitable for sufficient cross-linking for long term applications.

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Section: Introductionmentioning

confidence: 99%

Improving the Long-Term Performance of Poly(Vinyl Chloride)

Brostow¹,

Fałtynowicz²,

Hnatchuk³

et al. 2022

ChChT

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“…Among a wide range of hydrophilic polymers, the copolymers based on 2-hydroxyethylmethacrylate (HEMA) with polyvinylpyrrolidone (PVP) are promising [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. These materials are characterized by technological advantages of obtaining and a combination of unique properties, which open up the prospect of their use, such as hydrogel medical dressings [ 21 , 22 ], contact lenses [ 23 , 24 ], vascular prostheses [ 25 ], materials for regeneration of injured tissues [ 26 ], hydrogel membranes [ 27 ], enzyme immobilization systems [ 28 ], drug delivery systems [ 29 , 30 ], for the removal of adhesives from the back of canvas paintings [ 31 ], electrically controlled elements of optical systems [ 32 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Features of Structure and Properties of pHEMA-gr-PVP Block Copolymers, Obtained in the Presence of Fe2+

et al. 2020

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This paper presents the research results of the copolymer structure and properties of 2-hydroxyethylmethacrylate (HEMA) with polyvinylpyrrolidone (PVP) and their hydrogels, obtained by block polymerization in the presence of iron sulfate (II). By the methods of chemical analysis, IR spectroscopy, Thermogravimetric (TG) and Differential Thermal Analysis (DTA), the course of grafted copolymerization of HEMA on PVP with the formation of a cross-linked copolymer was confirmed. The results received by scanning electron microscopy showed that due to the copolymerization of HEMA with PVP, macroporous hydrogels with a pore size of 10–30 μm were obtained. The peculiarities of the structure formation of the obtained copolymers depending on the initial composition formulation were established and their structural parameters were investigated: PVP grafting efficiency, PVP content in copolymer, molecular weight of internodal fragment of polymer network, crosslinking degree, and crosslinking density. The interrelation of sorption–diffusion, physical–mechanical and thermophysical properties along with the structure of the obtained materials was proved. It was shown that with the increasing PVP content in the original composition, the efficiency of its grafting and crosslinking density of the polymer network decreased, but the surface hardness, heat resistance, sorption capacity of copolymers in the dry state, as well as ion permeability and elasticity in the swollen state increased, while their tensile strength deteriorated. It is proved that by changing the original composition formulation it is possible to change the structure and hence the properties of the copolymers in the desired direction.

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“…Xu et al reported an increase in the ESR of the neat PHEMA from ~45% to ~65% observed for the poly(HEMA-co-VP) hydrogels with 25% PVP content. Similarly, the PVP component increases the ESR of PHEMA/PVP IPNs from 49.1 to 72.3% upon increasing the PVP content from 25.3 to 78.7% [ 17 ]. While the PVP inclusion enhances the swelling capacity of PHEMA hydrogels with ~20%, the PDMAM component inclusion could increase almost twice the PHEMA/PDMAM IPN swelling ability, which is also expected to enhance their drug loading capacity.…”

Section: Resultsmentioning

confidence: 99%

Interpenetrating Polymer Networks of Poly(2-hydroxyethyl methacrylate) and Poly(N, N-dimethylacrylamide) as Potential Systems for Dermal Delivery of Dexamethasone Phosphate

Simeonov,

Kostova,

Vassileva

2023

Pharmaceutics

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In this study, a series of novel poly(2-hydroxyethyl methacrylate) (PHEMA)/poly(N,N′-dimethylacrylamide) (PDMAM) interpenetrating polymer networks (IPNs) were synthesized and studied as potential drug delivery systems of dexamethasone sodium phosphate (DXP) for dermal application. The IPN composition allows for control over its swelling ability as the incorporation of the highly hydrophilic PDMAM increases more than twice the IPN swelling ratio as compared to the PHEMA single networks, namely from ~0.5 to ~1.1. The increased swelling ratio of the IPNs results in an increased entrapment efficiency up to ~30% as well as an increased drug loading capacity of DXP up to 4.5%. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show the formation of a solid dispersion between the drug DXP and the polymer (IPNs) matrix. Energy-dispersive X-ray (EDX) spectroscopy shows an even distribution of DXP within the IPN structure. The DXP release follows Fickian diffusion with ~70% of DXP released in 24 h. This study demonstrates the potential of the newly developed IPNs for the dermal delivery of DXP.

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Preparation and properties of morphology controlled poly(2-hydroxyethyl methacrylate)/poly(N-vinyl pyrrolidone) double networks for biomedical use

Cited by 17 publications

References 21 publications

Improving the Long-Term Performance of Poly(Vinyl Chloride)

Improving the Long-Term Performance of Poly(Vinyl Chloride)

Features of Structure and Properties of pHEMA-gr-PVP Block Copolymers, Obtained in the Presence of Fe2+

Interpenetrating Polymer Networks of Poly(2-hydroxyethyl methacrylate) and Poly(N, N-dimethylacrylamide) as Potential Systems for Dermal Delivery of Dexamethasone Phosphate

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