Preparation and properties of hyperbranched poly(amidoamine) grafted onto a colloidal silica surface

Kaneko, Yutaka; Imai, Yuhsuke; Shirai, Kumi; Yamauchi, Takeshi; Tsubokawa, Norio

doi:10.1016/j.colsurfa.2006.04.036

Cited by 39 publications

(32 citation statements)

References 15 publications

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“…The basic chemical structure of HPAE-OHs4 and HPAE-co-PLA were further confirmed by 13 C-NMR, and the spectra were shown in Figure 2 C-NMR spectra of the HPAE-co-PLA copolymer showed that the peak at $170 ppm was attributed to the C¼ ¼O group carbon peak of polylactide. The signals at 68 and 70 ppm were assigned to CH group carbon peak of the polylactide moiety located at the terminal groups and the repeat units of it in the chain.…”

mentioning

confidence: 72%

“…[8][9][10] It is also suitable for a wide range of biomedical applications including drug delivery, detoxication, microarray systems and catalysis. [11][12][13] Dendrimers which may have more defined and ordered branching structure have to be obtained step by step with time-consuming and expensive synthetic and purification procedures. 14,15 In comparison, hyperbranched polymer, which has similar figuration as dendrimer and was synthesized much easier than dendrimer, may be a new type of potential application for the drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

“…The polymers were then designed to introduce the PLA by modification of the surface hydroxyl groups of the product. The copolymers were characterized on the basis of 1 H-NMR, 13 C-NMR, and FTIR measurements. Bovine serum albumin is similar to serum albumin of in the abound presence of human body.…”

Section: Introductionmentioning

confidence: 99%

“…The chemical structures of copolymers were determined by FTIR, 1 H-NMR, 13 C-NMR, and TGA. Double emulsion (DE) and nanoprecipitation (NP) method were used to fabricate the nanoparticles of these copolymers encapsulating bovine serum albumin (BSA) as a model.…”

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confidence: 99%

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Synthesis and characterization of an amphiphilic hyperbranched poly(amine‐ester)‐co‐D,L‐lactide (HPAE‐co‐PLA) copolymers and their nanoparticles for protein drug delivery

Jiang

et al. 2010

J of Applied Polymer Sci

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A series of hyperbranched poly(amineester)-co-D,L-lactide (HPAE-co-PLA) copolymer were synthesized by ring-opening polymerization of D,L-lactide with Sn(Oct) 2 as catalyst to a fourth generation branched poly(amine-ester) (HPAE-OHs4). The chemical structures of copolymers were determined by FTIR, 1 H-NMR, 13C-NMR, and TGA. Double emulsion (DE) and nanoprecipitation (NP) method were used to fabricate the nanoparticles of these copolymers encapsulating bovine serum albumin (BSA) as a model. DSC thermo-grams indicated that the nanoparticles with BSA kept stable below 40 C. Different factors which influence on particular size and encapsulation efficiency (EE) were investigated. Their EE to BSA could reach 97.8% at an available condition. In vitro release behavior of NPs showed a continuous release after a burst release. The stability maintenance of BSA in the nanoparticle release in vitro was also measured via circular dichroism and fluorescence spectrometry. The results showed that the copolymer nanoparticles have a promising potential in protein delivery system.

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mentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Synthesis and characterization of an amphiphilic hyperbranched poly(amine‐ester)‐co‐D,L‐lactide (HPAE‐co‐PLA) copolymers and their nanoparticles for protein drug delivery

Jiang

et al. 2010

J of Applied Polymer Sci

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“…7,8 It was reported that the grafting of polymers from particle surface was successfully achieved by atom transfer polymerization initiated by the system consisting of surface groups and transition metal complex. 9,10 The grafting of polymers onto colloidal silica surface was also reported by Yoshinaga et al [11][12][13] On the other hand, various kinds of antibacterial polymer polymers were reported. [14][15][16][17] For example, alkyl phosphonium polymer shows extremely strong antibacterial nature to Escherichia coli and Staphylococcus aureus.…”

mentioning

confidence: 99%

Preparation of Antibacterial Polymer-grafted Nano-sized Silica and Surface Properties of Silicone Rubber Filled with the Silica

Yamashita

Takeuchi

Kikuchi

et al. 2006

Polym J

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ABSTRACT:Antibacterial polymer was grafted onto nano-sized silica surface and the surface properties of silicone rubber filled with the silica were investigated. The grafting of antibacterial polymer was carried out by two-step reactions as follows. Poly(p-styrene sodium sulfate) (poly(St-SO 3 À Na þ )) was successfully grafted onto nano-sized silica surface by the radical polymerization of St-SO 3 À Na þ initiated by the system consisting of trichloroacetyl groups on the silica surface and Mo(CO) 6 : trichloroacetyl groups were introduced onto the silica surface by the reaction of amino groups with trichloroacetyl isocyanate. The percentage of poly(St-SO 3 À Na þ ) grafting increased with progress of the polymerization and reached about 30%. The poly(St-SO 3 À Na þ )-grafted silica was treated with tributyltetradecylphosphonium chloride (Bu 3

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Layer‐By‐Layer Dendritic Growth of Hyperbranched Thin Films for Surface Sol–Gel Syntheses of Conformal, Functional, Nanocrystalline Oxide Coatings on Complex 3D (Bio)silica Templates

Wang

Fang

Kim

et al. 2009

Adv Funct Materials

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Here, a straightforward and general method for the rapid dendritic amplification of accessible surface functional groups on hydroxylated surfaces is described, with focus on its application to 3D biomineral surfaces. Reaction of hydroxyl‐bearing silica surfaces with an aminosilane, followed by alternating exposure to a dipentaerythritol‐derived polyacrylate solution and a polyamine solution, allows the rapid, layer‐by‐layer (LBL) build‐up of hyperbranched polyamine/polyacrylate thin films. Characterization of such LBL‐grown thin films by AFM, ellipsometry, XPS, and contact angle analyses reveals a stepwise and spatially homogeneous increase in film thickness with the number of applied layers. UV–Vis absorption analyses after fluorescein isothiocyanate labeling indicate that significant amine amplification is achieved after the deposition of only 2 layers with saturation achieved after 3–5 layers. Use of this thin‐film surface amplification technique for hydroxyl‐enrichment of biosilica templates facilitates the conformal surface sol–gel deposition of iron oxide that, upon controlled thermal treatment, is converted into a nanocrystalline (∼9.5 nm) magnetite (Fe3O4) coating. The specific adsorption of arsenic onto such magnetite‐coated frustules from flowing, arsenic‐bearing aqueous solutions is significantly higher than for commercial magnetite nanoparticles (≤50 nm in diameter).

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Preparation and properties of hyperbranched poly(amidoamine) grafted onto a colloidal silica surface

Cited by 39 publications

References 15 publications

Synthesis and characterization of an amphiphilic hyperbranched poly(amine‐ester)‐co‐D,L‐lactide (HPAE‐co‐PLA) copolymers and their nanoparticles for protein drug delivery

Synthesis and characterization of an amphiphilic hyperbranched poly(amine‐ester)‐co‐D,L‐lactide (HPAE‐co‐PLA) copolymers and their nanoparticles for protein drug delivery

Preparation of Antibacterial Polymer-grafted Nano-sized Silica and Surface Properties of Silicone Rubber Filled with the Silica

Layer‐By‐Layer Dendritic Growth of Hyperbranched Thin Films for Surface Sol–Gel Syntheses of Conformal, Functional, Nanocrystalline Oxide Coatings on Complex 3D (Bio)silica Templates

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