Preparation and properties of dense and porous calcium phosphate

Milosevski, M.; Bossert, J.; Milosevski, D.; Gruevska, N.

doi:10.1016/s0272-8842(99)00003-6

Cited by 79 publications

(46 citation statements)

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“…Control of the microporosity and roughness of the ceramic walls and struts will also help to manipulate cell attachment and osseointegration, issues that will be addressed in the future work. Compressive strength of lamellar HA scaffolds prepared by freeze casting vs. reported values for materials fabricated using conventional techniques [2][3][4][5][6][7][8][9][10]. The typical pore sizes of conventional porous HA scaffolds are on the order of 100 to 800 µm in order to allow bone ingrowth.…”

Section: Discussionmentioning

confidence: 99%

“…Our preliminary tests indicate that the compressive strength of the robocasted grids ranges between 25 to 40 MPa. This is of the order of porous calcium phosphates with similar porosity (~ 45 %) fabricated by conventional techniques [2][3][4][5][6][7][8][9][10] and slightly higher than the corresponding value for cancellous bone (7-10 MPa) [20]. No de-bonding of the lines was observed during testing, indicating excellent adhesion between the printed lines.…”

Section: Robocastingmentioning

confidence: 98%

“…The scaffold must provide the necessary support for cells to proliferate and slowly degrade and resorb as the tissue structures grow in vitro and/or in vivo [1]. In conventional porous scaffold fabrication methods [2][3][4][5][6][7][8][9][10] it is difficult to precisely control pore size, geometry and spatial distribution, to create internal channels within the scaffold for vascularization, and to produce scaffolds with arbitrary and complex 3-D anatomical shapes.…”

Section: Introductionmentioning

confidence: 99%

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Porous ceramic scaffolds with complex architectures

Munch

Franco

Deville

et al. 2008

JOM

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This work compares two novel techniques for the fabrication of ceramic scaffolds for bone tissue engineering with complex porosity: robocasting and freeze casting. Both techniques are based on the preparation of concentrated ceramic suspensions with suitable properties for the process. In robocasting, the computer-guided deposition of the suspensions is used to build porous materials with designed three dimensional (3-D) geometries and microstructures. Freeze casting uses ice crystals as a template to form porous lamellar ceramic materials. Preliminary results on the compressive strengths of the materials are also reported.

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Section: Discussionmentioning

confidence: 99%

Section: Robocastingmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Porous ceramic scaffolds with complex architectures

Munch

Franco

Deville

et al. 2008

JOM

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“…Es tambiŽn interesante comparar las propiedades mec ‡nicas del material cer ‡mico ternario desarrollado aqu' con las de TiO 2 puro obtenido por sinterizado de polvos de sol-gel (14). TiO 2 es bien conocido por ser un material bio-inerte que tambiŽn despierta interŽs para aplicaciones en medicina (15).…”

Section: Resultados Y Discusiînunclassified

Preparación y propiedades de materiales cerámicos bioinertes en el sistema Al2O3-TiO2-SiO2

Milosevski¹,

Milosevska²,

Spaseska³

et al. 1998

Bol. Soc. Esp. Ceram. Vidr.

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Se han obtenido polvos cer ‡micos muy finos (100-600 nm) y de alta sinterabilidad, en el sistema Al 2 O 3 -TiO 2 -SiO 2 , por el mŽto-do de co-hidr-lisis controlada a partir de precursores organo-met ‡licos. Los compactos fabricados a partir del polvo de cohidr-lisis calcinado fueron sinterizados en el rango de temperaturas 1320-1380 ¡C, obteniŽndose densidades elevadas (~ 92% D.T.). El coeficiente de expansi-n tŽrmica tŽcnico del material cer ‡mico sinterizado fue medido por dilatometr'a. El valor obtenido, 8.8 10 -6 ¡C -1 , es muy similar al de titanio met ‡lico y por lo tanto el material cer ‡mico Al 2 O 3 -TiO 2 -SiO 2 puede ser candidato para la fabricaci-n de implantes compuestos cer ‡mico/metal. Las propiedades mec ‡nicas: m-dulo de elasticidad, resitencia a la flexi-n y resistencia a la compresi-n, del material denso sinterizado, fueron determinadas, resultando muy superiores a las de TiO 2 puro. Se obtuvieron materiales cer ‡micos de alta porosidad (P~ 65 %) por el mŽtodo de evaporaci-n de per-xido de hidr-geno. Estos materiales exhibieron porosidad interconectada y sus propiedades mec ‡nicas, en particular el m-dulo de Young, resultaron similares a las de material -seo, como se requiere para el dise-o de implantes quiroergicos. Palabras clave: biocer ‡micos, aloemina-titania-silica, co-hidr-lisis, resistencia mec ‡nica, porosidad Proccessing and properties of bioinert ceramic materials in the system Al 2 O 3 -TiO 2 -SiO 2Very fine and sinterable ceramic powders (100-600 nm) in the system Al 2 O 3 -TiO 2 -SiO 2 were obtained by the method of cohydrolisis from organo-metallic precursors. Isostatically pressed powder compacts could be densified to a relative high density (~ 92 % th. density) at relative low temperatures (1320-1380¡C). The technical coefficient of thermal expansion was measured by dilatometry. The value obtained (8.8 10 -6 1/¡C) corresponds closely to that of Ti, opening the possibility to use Al 2 O 3 -TiO 2 -SiO 2 ceramics to fabricate metal/ceramic composite implants. The measured mechanical properties of dense sintered Al 2 O 3 -TiO 2 -SiO 2 material: YoungÕs modulus, flexure strength and compression strength, are higher than those of pure TiO 2 . Highly porous Al 2 O 3 -TiO 2 -SiO 2 ceramics (P~ 65%) were obtained by the method of evaporation of hydrogen peroxide. These materials exhibited interconnected porosity and their properties, particularly the YoungÕs modulus, resulted very similar to those of bone, which is an important pre-requisite for the design of quirurgical implants. Keywords: bioceramics, alumina-titania-silica, co-hydrolysis, mechanical resistance, porosity INTRODUCCIîNMateriales biocer ‡micos son aquellos materiales cer ‡micos espec'ficamente dise-ados para ser usados en la fabricaci-n de implantes quiroegicos, pr-tesis y -rganos artificiales y para cumplir una determinada funci-n fisiol-gica en el cuerpo humano (1). De acuerdo a su actividad qu'mica en el entorno del organismo humano, los materiales biocer ‡micos se clasifican en tres grupos, que incluyen : I) mater...

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“…The mentioned ceramics have excellent biocompatibility and bone bonding or bone regeneration properties. They have been widely used in no or low load-bearing applications (Milosevski et al 1999). Furthermore, natural polymers like collagen have been used for bone tissue engineering purposes (Hutmacher et al 2001a;Lauer et al 2001).…”

Section: Pre-conditions Of Bone Surrogatesmentioning

confidence: 99%