Preparation and Properties of Chitosan Graft Copolymer Nanoparticles Using Potassium Diperiоdatоnickelate

Abstract

Nanoparticles comprising chitosan-graft-poly (methyl methacrylate) (CS-g-PMMA) copolymer were successfully synthesized in aqueous solution by using potassium diperiоdatоnickelate (Ni (IV)) as an initiator. The nanoparticles were characterized in terms of Fourier transform infrared (FTIR), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results indicated that chitosan was covalently linked to poly (methyl methacrylate) (PMMA) and the particles were uniform, spherical and well dispersed with narrow size distribution. Paclitaxel-loaded nanoparticles were prepared and in vitro release showed that these nanoparticles provided an initial burst release followed by a slowly sustained release for more than 16 days. Therefore, this process method would be used for synthesizing natural polymer graft copolymer nanoparticles with wide prospect.