Preparation and properties of A–B–A tri-block copolymer membranes consisting of N-hydroxypropyl-l-glutamine as the A component and l-alanine as the B component

Yodoya, Shinya; Takagi, Tetsuya; Kurotani, Michiyoshi; Hayashi, Takanori; Nagata, Minoru; Oka, M.; Hayashi, Toshio

doi:10.1016/s0014-3057(02)00349-x

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…Tri‐block copolymers have sparked much interest and their potential has been realized in many areas. These block copolymers have been used as thermoplastic elastomer,23 adhesives,24 hot‐melt adhesives,25 blend compatibilizers,26 membranes,27 drug delivery polymers,28 and biodegradable polymers 29. Synthesis of polyurethane‐polyvinyl multiblock copolymers through polyurethane‐based iniferters30, 31 were reported already and it was found that these block copolymers have been synthesized through CRP mechanism.…”

Section: Introductionmentioning

confidence: 98%

Novel poly(methyl methacrylate)‐block‐polyurethane‐block‐poly(methyl methacrylate) tri‐block copolymers through atom transfer radical polymerization

Kannan

Verma

Jang

et al. 2008

J of Applied Polymer Sci

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Poly(methyl methacrylate)-block-polyurethane-block-poly(methyl methacrylate) tri-block copolymers have been synthesized successfully through atom transfer radical polymerization of methyl methacrylate using telechelic bromo-terminated polyurethane/CuBr/ N,N,N,N 00 ,N 00 -pentamethyldiethylenetriamine initiating system. As the time increases, the number-average molecular weight increases linearly from 6400 to 37,000. This shows that the poly methyl methacrylate blocks were attached to polyurethane block. As the polymerization time increases, both conversion and molecular weight increased and the molecular weight increases linearly with increasing conversion. These results indicate that the formation of the triblock copolymers was through atom transfer radical polymerization mechanism. Proton nuclear magnetic resonance spectral results of the triblock copolymers show that the molar ratio between polyurethane and poly (methyl methacrylate) blocks is in the range of 1 : 16.3 to 1 : 449.4. Differential scanning calorimetry results show T g of the soft segment at 2358C and T g of the hard segment at 758C.

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Section: Introductionmentioning

confidence: 98%

Novel poly(methyl methacrylate)‐block‐polyurethane‐block‐poly(methyl methacrylate) tri‐block copolymers through atom transfer radical polymerization

Kannan

Verma

Jang

et al. 2008

J of Applied Polymer Sci

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“…However, its lack of biodegradability limits its application in the field of biomaterials. Previous studies have introduced L-amino acids into non-degradable polymers [ 7 , 8 , 9 ] to make the non-degradable materials biodegradable. The reason is that amino acids can endow the polymer materials with bioactive sites similar to peptide materials, and also provide enzymatic hydrolysis sites for the biodegradation of polymers [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Polyoxyethylene Diamine Modification of Poly(amide-imide)-polyethylene Glycol Exhibits Excellent Hydrophilicity, Degradability, and Biocompatibility

Chen

et al. 2022

Polymers

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We designed and synthesized the polyoxyethylene diamine (H2N-PEG-NH2) and poly(amide-imide)-polyethylene glycol (PAI-PEG) copolymers. The physical and chemical properties, mechanical properties, and in vitro biocompatibility of the materials were characterized. The results showed that the best elongation at break and recovery were obtained when the amount of PEG was 5 wt%. With the increase in PEG content, the degradation rate, hydrophilic property, tensile strength and tensile modulus of the copolymer decreased to a certain extent. The material had the best thermal stability and mechanical properties when 5 wt% PEG was added. Cytocompatibility evaluation showed that the addition of PEG could enhance the cell compatibility of the material and make it potentially suitable for application in bone repair.

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“…The incorporation of l -amino acids into a polymeric molecular chain has attracted significant attention because of the broad applications of biodegradable polymers in biomedical, drug-delivery, pharmaceutical and tissue engineering [ 11 , 12 , 13 , 14 ]. Many studies have shown that non-biodegradable polymers become biodegradable when incorporated with l -amino acid [ 15 , 16 , 17 , 18 , 19 , 20 ]. The reason why l -amino acid-incorporated polymers are biodegradable is thought to be that the incorporation of l -amino acid may be targeted for cleavage by proteases [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

A Highly Hydrophilic and Biodegradable Novel Poly(amide-imide) for Biomedical Applications

et al. 2016

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A novel biodegradable poly(amide-imide) (PAI) with good hydrophilicity was synthesized by incorporation of L-glycine into the polymer chain. For comparison purposes, a pure PAI containing no L-glycine was also synthesized with a three-step method. In this study, we evaluated the novel PAI's thermal stability, hydrophilicity, solubility, biodegradability and ability to support bone marrow mesenchymal stem cell (BMSC) adhesion and growth by comparing with the pure PAI. The hydrophilic tests demonstrated that the novel PAI has possible hydrophilicity at a 38 • water contact angle on the molecule surface and is about two times more hydrophilic than the pure PAI. Due to an extra unit of L-glycine in the novel PAI, the average degradation rate was about 2.4 times greater than that of the pure PAI. The preliminary biocompatibility studies revealed that all the PAIs are cell compatible, but the pure PAI exhibited much lower cell adhesion than the L-glycine-incorporated novel PAI. The hydrophilic surface of the novel PAI was more suitable for cell adhesion, suggesting that the surface hydrophilicity plays an important role in enhancing cell adhesion and growth.

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Preparation and properties of A–B–A tri-block copolymer membranes consisting of N-hydroxypropyl-l-glutamine as the A component and l-alanine as the B component

Cited by 7 publications

References 13 publications

Novel poly(methyl methacrylate)‐block‐polyurethane‐block‐poly(methyl methacrylate) tri‐block copolymers through atom transfer radical polymerization

Novel poly(methyl methacrylate)‐block‐polyurethane‐block‐poly(methyl methacrylate) tri‐block copolymers through atom transfer radical polymerization

Polyoxyethylene Diamine Modification of Poly(amide-imide)-polyethylene Glycol Exhibits Excellent Hydrophilicity, Degradability, and Biocompatibility

A Highly Hydrophilic and Biodegradable Novel Poly(amide-imide) for Biomedical Applications

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