Abstract:Lumefantrine contributes significant roles in artemisinin-based combination therapy for malaria treatment but associated with a limitation of poor aqueous solubility and low permeability. This study investigated lumefantrine-2-hydroxypropyl-β-cyclodextrin complex to improve its solubility profile. A phase-solubility analysis and molecular modelling were carried out before the preparation of the complex by physical mixture, kneading, co-evaporation and freeze-drying methods. Fourier transform infrared (FT-IR) s… Show more
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