Preparation and physico-chemical characterization of chitin and chitosan from the pens of the squid species, and

Chandumpai, Ausa; Singhpibulporn, Narongsak; Faroongsarng, Damrongsak; Sornprasit, Prasart

doi:10.1016/j.carbpol.2004.08.015

Cited by 104 publications

(76 citation statements)

References 15 publications

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“…DNC-fabrication techniques are classified as either "top-down" or "bottom-up" methods, based on the size-change process. 183 The top-down method starts from large crystals to small NCs in a step-by-step manner during a high-energy process, such as pearl milling and high-pressure homogenization. 182,[184][185][186] The bottom-up method involves procedures that start from molecules to NCs, such as solvent exchange, 21,[187][188][189] high-gravity-control precipitation, 188,190,191 evaporative precipitation, 192 rapid expansion of supercritical solution, 193 and supercritical antisolvent methods.…”

Section: Drug Nanocrystalsmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Drug Nanocrystalsmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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“…Two protocols of deacetylation were developed and implemented based on reports from different authors, in order to generate a standard working protocol [6,[12][13][14].…”

Section: Chitosan Isolationmentioning

confidence: 99%

“…Chitosan is at present one of most studied biopolymers because of its solubility in aqueous solutions of some acids since it shows some alkylations [4][5][6], and as a consequence the number of applications in various fields has increased.…”

Section: Introductionmentioning

confidence: 99%

Isolation of chitosan from Ganoderma lucidum mushroom for biomedical applications

Ospina

Álvarez

Sierra

et al. 2015

J Mater Sci: Mater Med

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Chitin biopolymer production and its by-product chitosan show great potential. These biomaterials have great applicability in various fields because they are non-toxic, biodegradable, biocompatible, and have antimicrobial effects. The most common source of chitin and chitosan is the crustaceous shell; however, mushrooms are an alternative source for isolating these biopolymers because their cellular wall has a high content of chitin, which may be transformed into chitosan through a deacetylation reaction. The main objective of this research was to obtain chitosan through the deacetylation of chitin isolated from the Ganoderma lucidum basidiomycetes mushroom, which is obtained through biotechnological culture. The material characterization was performed using X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, and an evaluation of cytotoxicity comparing the results obtained with results for commercial chitosan. Protocol results showed that chitosan obtained from this mushroom had a significant similitude with commercial chitosan, yet the one obtained using P2 protocol was the one that rendered the best results: including diffractogram peaks, characteristic infrared analysis bands, and an 80.29 % degree of deacetylation. Cytotoxicity in vitro testing showed that the material was non-toxic; furthermore, it rendered very promising information regarding the evaluation of future applications of this biomaterial in the field of biomedicine.

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“…Squid is another important source of chitin in which it exists in the β form which was found to be more amenable for deacetylation. It also shows higher solubility, higher reactivity, and higher affinity toward solvents and swelling than α-chitin due to much weaker intermolecular hydrogen bonding ascribable to the parallel arrangement of the main chains (Pawadee et al 2003;Gardner and Blakwell 1975;Hunt and Elsherief 1990;Chandumpaia et al 2004). The production of chitosan from crustacean shells obtained as a food waste is economically feasible, especially if it includes the recovery of carotenoids.…”

Section: Introductionmentioning

confidence: 97%

Chitosan-Based Edible Films

Elsabeé¹

2015

Polysaccharides

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Preparation and physico-chemical characterization of chitin and chitosan from the pens of the squid species, and

Cited by 104 publications

References 15 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Isolation of chitosan from Ganoderma lucidum mushroom for biomedical applications

Chitosan-Based Edible Films

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