Preparation and performance evaluation of tetracycline hydrochloride loaded wound dressing mats based on electrospun nanofibrous poly(lactic acid)/poly(ϵ‐caprolactone) blends

Abstract

ABSTRACT:In this article, we present the drug-release rate, water uptake, water permeability, morphology, and mechanical properties of a series of active wound dressing nanofibrous mats prepared via an electrospinning process of poly(lactic acid) (PLA), poly(e-caprolactone) (PCL), and their (50/50) blends loaded with different doses of tetracycline hydrochloride antibiotic. The performance of these active wound dressings in terms of a sustained and suitable drug-release rate, adequate water uptake and water permeability, and antibacterial activities were compared with those of a commercial wound dressing (Comfeel Plus). The results show that the dressings made from PCL and PLA/PCL blends showed better performance compared with the commercial wound dressing sample as far as these properties were concerned. The improved performance could be explained on the basis of the nanofibrous structure of the mats and the hydrophilicity of PCL and PLA.

Centrifugal spun ultrafine fibrous web as a potential drug delivery vehicle

“…Tetracycline released from the C-spun fibrous web effectively inhibits the growth of gram positive bacteria such as S.epidermidis and B.megaterium which gives the zone of inhibition 42 mm 46 mm and moderately inhibits the growth of gram negative bacterium such as E.coli and P.aeruginosa which gives the zone of inhibition around 33 mm, 31 mm. The antimicrobial activity of tetracycline is more efficient to gram positive bacteria than gram nega- tive and it can be attribute the cell wall differentiations as reported in the literature [29]. Figure 9 shows the release profile of tetracycline loaded C-spun fibers for both PCL, PCL/PVP blends.…”

Multilayered Controlled Released Topical Patch Containing Tetracycline for Wound Dressing

“…In the Zamani et al [8] study, a PCL electrospun sheet provided a sustainable drug release system which lasted for 19 days [8]. Similarly, the Zahedi et al [17] showed that a PVA/PCL (80/20) electrospun sheet had a much better drug release rate for Tetracycline as a drug model compared with cast film samples containing the same drug [17].…”

Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials

“…[34] With electrospun materials being suited for bandaging applications, drug loaded electrospun mats have been prepared for wound dressings, such as antibacterial tetracycline hydrochloride loaded poly-ε-caprolactone (PCL)/polylactic acid blend electrospun materials. [35] These materials showed superior performance to commercial Comfeel wound dressings, with improved water-uptake capacity, 600% versus 100% respectively, as well as adding effective antibacterial properties, showing continuous release of tetracycline hydrochloride over 48 h and effectively killing all Escherichia coli and Staphylococcus aureus in agar plates. [35] This approach can be used for protein growth factors, whose large size and instability can be an obstacle for delivery from the blood stream across size-selective membranes such as the BBB.…”

“…[35] These materials showed superior performance to commercial Comfeel wound dressings, with improved water-uptake capacity, 600% versus 100% respectively, as well as adding effective antibacterial properties, showing continuous release of tetracycline hydrochloride over 48 h and effectively killing all Escherichia coli and Staphylococcus aureus in agar plates. [35] This approach can be used for protein growth factors, whose large size and instability can be an obstacle for delivery from the blood stream across size-selective membranes such as the BBB. Human β-NGF, in the presence of the stabilizing carrier protein bovine serum albumin, has been successfully electrospun with PCL dissolved in chloroform (CHCl 3 ) [36] and PCL/ poly-ε-caprolactone ethyl ethylene phosphate blend in dichloromethane.…”