Preparation and optimization of various parameters of enteric coated pellets using the Taguchi L9 orthogonal array design and their characterization

Shravani, D.; Lakshmi, P. K.; Balasubramaniam, J.

doi:10.1016/j.apsb.2011.04.005

Cited by 38 publications

(15 citation statements)

References 14 publications

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“…In 0.1 N HCl (pH 1.2), formulation F1 exhibited a release of approximately 3 % in 120 min as well as a faster release pattern (approximately 80 % in 60 min) of DLX in phosphate buffer (pH 6.8) as compared to formulations F2, F3, and the marketed product, respectively. This may be attributed to the low amount of enteric polymers present in the formulation (Cao et al 2013;Mohamed et al 2013;Shravani et al 2011), which could not resist the release of drug in the acidic dissolution medium. On the other hand, formulations F2, F3, and the marketed product showed no release of drug in 0.1 N HCl (pH 1.2) in 120 min indicating the effectiveness of the enteric coating polymer.…”

Section: In Vitro Dissolution Studies Of Enteric-coated DLX Pelletsmentioning

confidence: 95%

“…dual inhibition, tolerability, safety, faster recovery, fewer side effects, and low affinity for other neuronal receptors (Bymaster et al 2001;Sharma et al 2000;Westanmo et al 2005). However, the drug was found to be acid labile, which results in its degradation in a gastric environment, thus necessitating the need for development of an entericcoated system (Shravani et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Preparation and evaluation of enteric-coated delayed-release pellets of duloxetine hydrochloride using a fluidized bed coater

et al. 2015

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In this study, the enteric-coated delayed-release pellets of duloxetine hydrochloride (DLX) were formulated using a fluidized bed coater. Three separate layers, the drug layer, the barrier layer, and the enteric layer, were coated onto inert core pellets. Among the three formulations (F1-F3), the dissolution profiles of formulation F2 were most similar to those of the marketed product, with similarity and difference factors of 83.99 and 3.77, respectively. In addition, pharmacokinetic parameters of AUC, C(max), T(max), t(1/2), K(el), and MRT of DLX for the developed formulation (F2) did not differ significantly from those for the marketed product in beagle dogs, suggesting that they were bioequivalent. Our results demonstrated that the in vitro dissolution data resembled the in vivo performance of the drug. Therefore, this study has a positive scope for further scale up and development of the formulation for achievement of the generic product.

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Section: In Vitro Dissolution Studies Of Enteric-coated DLX Pelletsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of enteric-coated delayed-release pellets of duloxetine hydrochloride using a fluidized bed coater

et al. 2015

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“…This saves both time and resources. 12 Taguchi techniques can determine the experimental conditions with the least variability as the optimal condition. The Taguchi method uses the signalto-noise (S/N) ratio to measure the quality characteristic deviating from the desired value.…”

Section: Taguchi Techniquementioning

confidence: 99%

Influence of nickel recovery efficiency on crystallinity and microhardness of electroless Ni–P coatings and optimisation using Taguchi technique

Muraliraja

Elansezhian

2015

Transactions of the IMF

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This research paper reports on the improvement of nickel recovery efficiency (NRE) and microhardness of the electroless Ni-P coating process. At present, in the electroless nickel coating process, the NRE is very low. Owing to this reason, the coating cost of electroless nickel is very high. Earlier researchers have tried to recover the nickel from the used bath after coating is completed and some achieved success in their attempt by further improving the nickel recovery from 25 to 35%. To overcome the above problem, the excess amount of reducing agent (RA) is supplied to the bath during the coating process to compensate for the consumed amount of electrons. The influence of adding excess amount of RA on NRE and other properties of the deposit have been investigated in this study. The NRE was significantly increased from 35 to 61%.The various coatings parameters used in the electroless bath were optimised to get the high NRE using a Taguchi optimisation technique.

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“…Orthogonal array design (OAD), a type of factorial design, was used to optimize the experimental conditions with a fewer number of experiments [24,25]. OAD is particularly advantageous for the rapid characterization of complicated processes using fewer experiments.…”

Section: Optimization Of Magnetic Solid Base Catalyst Preparation Conmentioning

confidence: 99%

Magnetic Solid Base Catalysts for the Production of Biodiesel

Guo

Huang

Zheng

et al. 2011

J Americ Oil Chem Soc

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Magnetic solid base catalysts were prepared by loading Na 2 SiO 3 on Fe 3 O 4 nano-particles with Na 2 OÁ3SiO 2 and NaOH as precipitator. The catalysts were used to catalyze the transesterification reactions for the production of fatty acid methyl esters (FAME, namely biodiesel) from cottonseed oil. The optimum conditions of the catalysts' preparation and transesterification reactions were investigated by orthogonal experiments. The catalyst with the highest catalytic activity was obtained when Si/Fe molar ratio of 2.5, aging time of 2 h, calcination temperature of 350°C, calcination time of 2.5 h. Magnetic of the catalyst was characterized with Vibrating Sample Magnetometer (VSM) and transmission electron microscopy photograph (TEM), and the results showed the catalyst Na 2 SiO 3 /Fe 3 O 4 had good specific saturation magnetization and paramagnetism, and its water resistance was better than the traditional homogeneous base catalysts; under the transesterification conditions of methanol/oil molar ratio of 7:1, catalyst dosage of 5%, reaction temperature of 60°C, reaction time of 100 min and stirring speed of 400 rpm, yield of biodiesel was 99.6%. The lifetime and recovery rate of the magnetic solid base catalyst were much better than those of Na 2 SiO 3 .

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Preparation and optimization of various parameters of enteric coated pellets using the Taguchi L9 orthogonal array design and their characterization

Cited by 38 publications

References 14 publications

Preparation and evaluation of enteric-coated delayed-release pellets of duloxetine hydrochloride using a fluidized bed coater

Preparation and evaluation of enteric-coated delayed-release pellets of duloxetine hydrochloride using a fluidized bed coater

Influence of nickel recovery efficiency on crystallinity and microhardness of electroless Ni–P coatings and optimisation using Taguchi technique

Magnetic Solid Base Catalysts for the Production of Biodiesel

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