Preparation and optimization of monodisperse polymeric microparticles using modified vibrating orifice aerosol generator for controlled delivery of letrozole in breast cancer therapy
Abstract:Letrozole (LTZ) is effective for the treatment of hormone-receptor-positive breast cancer in postmenopausal women. In this work, and for the first time, using vibrating orifice aerosol generator (VOAG) technology, monodisperse poly-ε-caprolactone (PCL), and poly (D, L-Lactide) (PDLLA) LTZ-loaded microparticles were prepared and found to elicit selective high cytotoxicity against cancerous breast cells with no apparent toxicity on healthy cells in vitro. Plackett-Burman experimental design was utilized to ident… Show more
“…The size of formulation at least doubles the AUC, suggesting that the dose might be halved, thereby reducing side effects associated with this otherwise important drug. Recently, an Iron-Doped Fullerene Cage of Thiotepa has been prepared by Xuan Young to modify drug delivery (Alemrayat et al, 2018;Pandey et al, 2020). C3 N nanotubes (Ge et al, 2012;Torabifard and Fattahi, 2012;Fox et al, 2021).…”
Section: Tepadinamentioning
confidence: 99%
“…It has poor water solubility, rapid metabolism, and a range of side effects. Polymer-based nanoparticles (FDA, 2012a;Alemrayat et al, 2018;Caulfield et al, 2019;Leo et al, 2020), Lipid nanocomplex (Bhatnagar, 2007;Azandaryani et al, 2019;Yassemi et al, 2020), solid lipid nanoparticles (Khan et al, 2022), Pegylated nanoparticles (Kelly and Buzdar, 2010), are few of the novel formulations explored to overcome the limitations and side effects associated with Letrozole.s.…”
Breast cancer is one of the most diagnosed solid cancers globally. Extensive research has been going on for decades to meet the challenges of treating solid tumors with selective compounds. This article aims to summarize the therapeutic agents which are either being used or are currently under approval for use in the treatment or mitigation of breast cancer by the US FDA, to date. A structured search of bibliographic databases for previously published peer-reviewed research papers on registered molecules was explored and data was sorted in terms of various categories of drugs used in first line/adjuvant therapy for different stages of breast cancer. We included more than 300 peer-reviewed papers, including both research and reviews articles, in order to provide readers an useful comprehensive information. A list of 39 drugs are discussed along with their current status, dose protocols, mechanism of action, pharmacokinetics, possible side effects, and marketed formulations. Another interesting aspect of the article included focusing on novel formulations of these drugs which are currently in clinical trials or in the process of approval. This exhaustive review thus shall be a one-stop solution for researchers who are working in the areas of formulation development for these drugs.
“…The size of formulation at least doubles the AUC, suggesting that the dose might be halved, thereby reducing side effects associated with this otherwise important drug. Recently, an Iron-Doped Fullerene Cage of Thiotepa has been prepared by Xuan Young to modify drug delivery (Alemrayat et al, 2018;Pandey et al, 2020). C3 N nanotubes (Ge et al, 2012;Torabifard and Fattahi, 2012;Fox et al, 2021).…”
Section: Tepadinamentioning
confidence: 99%
“…It has poor water solubility, rapid metabolism, and a range of side effects. Polymer-based nanoparticles (FDA, 2012a;Alemrayat et al, 2018;Caulfield et al, 2019;Leo et al, 2020), Lipid nanocomplex (Bhatnagar, 2007;Azandaryani et al, 2019;Yassemi et al, 2020), solid lipid nanoparticles (Khan et al, 2022), Pegylated nanoparticles (Kelly and Buzdar, 2010), are few of the novel formulations explored to overcome the limitations and side effects associated with Letrozole.s.…”
Breast cancer is one of the most diagnosed solid cancers globally. Extensive research has been going on for decades to meet the challenges of treating solid tumors with selective compounds. This article aims to summarize the therapeutic agents which are either being used or are currently under approval for use in the treatment or mitigation of breast cancer by the US FDA, to date. A structured search of bibliographic databases for previously published peer-reviewed research papers on registered molecules was explored and data was sorted in terms of various categories of drugs used in first line/adjuvant therapy for different stages of breast cancer. We included more than 300 peer-reviewed papers, including both research and reviews articles, in order to provide readers an useful comprehensive information. A list of 39 drugs are discussed along with their current status, dose protocols, mechanism of action, pharmacokinetics, possible side effects, and marketed formulations. Another interesting aspect of the article included focusing on novel formulations of these drugs which are currently in clinical trials or in the process of approval. This exhaustive review thus shall be a one-stop solution for researchers who are working in the areas of formulation development for these drugs.
Numbers of developments are implemented in drug delivery system to achieve the goals of optimized efficacy, cost effectiveness of therapy. One of the latest, novel and highly evolving technologies is microsponge drug delivery system which gives controlled release and site specific delivery of active ingredients. They are highly cross linked, porous and polymeric microspheres with size range of 5-300µm. This system is emerging as valuable option for topical delivery of drugs due to characteristics like decreased side effects, improved stability, better formulation flexibility, superior product performance. It is having number of applications in oral, topical, ocular and biopharmaceuticals delivery. The current review describes microsponge technology and details of the formulation methods, evaluation, programmable release mechanisms and applications.
Keywords: Microsponges; Controlled release; Quasi emulsion solvent diffusion; Programmable drug release; Oral administration; Topical drug delivery.
“…Both methods can generate monodisperse particles and both offer flexibility in the size of the emulsions generated. In addition, monodisperse poly-ε-caprolactone was prepared by Alemrayat et al using vibrating orifice aerosol generator technology for the first time in 2018 [29]. Electrohydrodynamic atomization, a subfield of fluid mechanics, is also used in the preparation of monodisperse microspheres.…”
Staphylococcus aureus (SA) is one of the most common causes of hospital-acquired infections and foodborne illnesses and is commonly found in nature in air, dust, and water. The spread and transmission of SA aerosols in the air has the potential to cause epidemic transmission among humans and between humans and animals. To effectively provide the timely warning of SA aerosols in the atmosphere, the identification and detection of SA aerosol concentrations are required. Due to their homogeneous physicochemical properties, highly monodisperse submicron polystyrene (PS) microspheres can be used as one of the simulants of SA aerosols. In this study, 800 nm monodisperse fluorescent PS (f-PS) microspheres with fluorescence spectra and particle size distribution similar to those of SA were prepared. The 800 nm monodisperse f-PS microspheres had a fluorescence characteristic peak at 465 nm; in aerosols, 800 nm monodisperse f-PS microspheres with a similar particle size distribution to that of SA were further verified, mainly in the range of 500 nm–1000 nm; finally, it was found that the f-PS microspheres still possessed similar fluorescence characteristics after 180 days. The f-PS microspheres prepared in this study are very close to SA in terms of particle size and fluorescence properties, providing a new idea for aerosol analogs of SA.
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