Microsponge as an Emerging Technique in Novel Drug Delivery System

Microsponges are those drug delivery systems which are intended in a way to deliver a minimum dose of the drug or pharmaceutically active ingredient to increase the stability of formulation, to alter drug release profile. Ketoconazole is an imidazole anti-fungal agent belonging to BCS class II. The main objective of this research work is to formulate and evaluate ketoconazole microsponge for topical delivery by using various polymers such eudragit S-100, eudragit L-100 in four ratios 1:2, 1:3, 1:4, 1:5 by quasi emulsion method. The formulations prepared were labelled based on the ratios as ES 2. ES 3, ES 4, ES 5 for eudragit S-100 and EL 2, EL 3, EL 4, EL 5 for eudragit L-100. Evaluation tests like entrapment efficiency, production yield, drug content was performed and formulation of eudragit L-100 (EL 5) and eudragit S-100 (ES 5) showed better results. ES 5 and EL 5 formulations were optimized and tests like in vitro dissolution studies were conducted which showed that the formulation ES 5 showed released upto 8 hours and can be used in the formulation of gel. The gel (GES5) was prepared by usingmicrosponges containing the drug ketoconazole equivalent to 1 % w/w and was incorporated into the gel base made up of Carbopol 934. The microsponges were sieved and were dispersed in Carbopol gel. Evaluation tests like pH measurement, visual inspection, spreadability studies, drug content and in vitro diffusion studies. This method of formulating microsponges has improved drug delivery therefore helping in the enhancement of the bioavailability of the drug and also acts as an efficient carrier through the skin.

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“…The gel formulation containing microsponges was visually inspected by their colour, appearance and texture [10].…”

Section: Evaluation Of Ketoconazole Gel Visual Inspectionmentioning

confidence: 99%

Formulation and Evaluation of Ketoconazole Microsponge Topical Gel

Booravilli

Sirisolla

Saluru

2022

Int. J. Res. Pharm. Sci.

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“…Microsponges have the potential to deliver a wide range of compounds in a regulated way, including antimicrobials, sunscreens, anti-acne, and antiinflammatory agents. 9 In order to minimize transdermal penetration into the body and maximize the amount of time an active substance is available on the skin's surface or in the epidermis, delivery methods are required. The only polymeric microspheres that satisfy these criteria are those based on microsponge technology.…”

Section: Introductionmentioning

confidence: 99%

Microsponge: A Review

Kaur,

Rani,

Singh

et al. 2024

J. Drug Delivery Ther.

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Microsponge are little spherical molecules with a broad porous surface that resemble sponges. The use of microsponges is a unique medication delivery method that has several benefits. For a range of illnesses, the Microsponges drug delivery system is utilized to improve the effectiveness of oral, parenteral, or topical medicine administration. A novel approach of managing drug release and administering medication to specific locations is microsponge technology. The efficient and novel way that microsponge medicine administration advances properties, boosts item stability, and improves security can all contribute to the effectiveness of topically dynamic operators. In an effective and creative way, it can boost the efficiency of topically active medications while improving safety, product stability, and aesthetic qualities. Recently, microsponges, which are typically used topically, have also been employed for oral delivery. Microsponge Systems may suspend or trap a wide range of substances. They can also be integrated into a product that is made to resemble a gel, cream, liquid, or powder. Microsponge Systems are built on atomic, polymer-based microspheres. In topical medication solutions, microsponge technology has been employed to provide controlled release of active drug into the skin, therefore decreasing systemic exposure and local cutaneous responses to active pharmaceuticals. We will talk about microsponge's characteristics, benefits, and drawbacks as well as the drug release mechanism, formulation techniques, and assessment in this review paper. Keywords: Microsponge, NDDS, Novel drug delivery system, MDS

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“…In our previous works we presented the synthesis and physicochemical, functional, and biopharmaceutical characterization of diltiazem-loaded Eudragit RS microsponges [ 13 , 14 ]–a highly preferable drug-carrier system in solid as well as in semisolid dosage forms [ 15 , 16 ]. The microsponges were designated to serve as a controlled delivery system in diltiazem 2% rectal hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Ammonio Methacrylate Copolymer (Type B)-Diltiazem Interactions in Solid Dispersions and Microsponge Drug-Delivery Systems

et al. 2022

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This paper presents a complex analytical study on the distribution, solubility, amorphization, and compatibility of diltiazem within the composition of Eudragit RS 100-based particles of microspongeous type. For this purpose, a methodology combining attenuated total reflectance Fourier transform infrared (ATR-FTIR) absorption spectroscopy, differential scanning calorimetry (DSC), scanning electron microscopy with energy-dispersive X-ray microanalysis (SEM-EDX), and in vitro dissolution study is proposed. The correct interpretation of the FTIR and drug-dissolution results was guaranteed by the implementation of two contrasting reference models: physical drug–polymer mixtures and casting-obtained, molecularly dispersed drug–polymer composites (solid dispersions). The spectral behavior of the drug–polymer composites in the carbonyl frequency (νCO) region was used as a quality marker for the degree of their interaction/mutual solubility. A spectral-pattern similarity between the microsponge particles and the solid dispersions indicated the molecular-type dispersion of the former. The comparative drug-desorption study and the qualitative observations over the DSC and SEM-EDX results confirmed the successful synthesis of a homogeneous coamorphous microsponge-type formulation with excellent drug-loading capacity and “controlled” dissolution profile. Among them, the drug-delivery particles with 25% diltiazem content (M-25) were recognized as the most promising, with the highest population of drug molecules in the polymer bulk and the most suitable desorption profile. Furthermore, an economical and effective analytical algorithm was developed for the comprehensive physicochemical characterization of complex delivery systems of this kind.

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Microsponge as an Emerging Technique in Novel Drug Delivery System

Cited by 9 publications

References 13 publications

Formulation and Evaluation of Ketoconazole Microsponge Topical Gel

Formulation and Evaluation of Ketoconazole Microsponge Topical Gel

Microsponge: A Review

Ammonio Methacrylate Copolymer (Type B)-Diltiazem Interactions in Solid Dispersions and Microsponge Drug-Delivery Systems

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