Preparation and mechanistic aspect of natural xanthone functionalized gold nanoparticle

Patra, Nabanita; Dehury, Niranjan; Pal, Abhisek; Behera, Anindita; Patra, Srikanta

doi:10.1016/j.msec.2018.04.091

Cited by 24 publications

(15 citation statements)

References 43 publications

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“…In the images related to MG4, agglomerations of nanoparticles can be seen, which were counted 100 particles independents, and Figure 3d shows the Pareto diagram of the size distribution of NPs. Previous studies show a similar behavior in agglomerated nanoparticles of the same polymer loaded with catechins larger than 500 nm; however, there is evidence that nanometer sizes are achieved with PLGA-loaded gold [25,26]. The results shown by SEM coincide with peak two of Figure 2e, which shows an average size of 67.14.…”

Section: Mangiferin Release Profilesupporting

confidence: 76%

Mangiferin-Loaded Polymeric Nanoparticles: Optical Characterization, Effect of Anti-topoisomerase I, and Cytotoxicity

Razura-Carmona

Pérez-Larios

González-Silva

et al. 2019

Cancers

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Mangiferin is an important xanthone compound presenting various biological activities. The objective of this study was to develop, characterize physicochemical properties, and evaluate the anti-topoisomerase activity of poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing mangiferin. The nanoparticles were developed by the emulsion solvent evaporation method and the optimal formulation was obtained with a response surface methodology (RSM); this formulation showed a mean size of 176.7 ± 1.021 nm with a 0.153 polydispersibility index (PDI) value, and mangiferin encapsulation efficiency was about 55%. The optimal conditions (6000 rpm, 10 min, and 300 μg of mangiferin) obtained 77% and the highest entrapment efficiency (97%). The in vitro release profile demonstrated a gradual release of mangiferin from 15 to 180 min in acidic conditions (pH 1.5). The fingerprint showed a modification in the maximum absorption wavelength of both the polymer and the mangiferin. Results of anti-toposiomerase assay showed that the optimal formulation (MG4, 25 µg/mL) had antiproliferative activity. High concentrations (2500 µg/mL) of MG4 showed non-in vitro cytotoxic effect on BEAS 2B and HEPG2. Finally, this study showed an encapsulation process with in vitro gastric digestion resistance (1.5 h) and without interfering with the metabolism of healthy cells and their biological activity.

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Section: Mangiferin Release Profilesupporting

confidence: 76%

Mangiferin-Loaded Polymeric Nanoparticles: Optical Characterization, Effect of Anti-topoisomerase I, and Cytotoxicity

Razura-Carmona

Pérez-Larios

González-Silva

et al. 2019

Cancers

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“…HB is rich in polyphenols, of which MGF (62.721 mg/g) and hesperidin (40.742 mg/g) are the most abundant [ 22 ]. Although the synthesis of AuNPs has been reported for both MGF and hesperidin [ 6 , 10 , 23 ], MGF with its four hydroxyl groups and a glucose unit exhibits stronger bio-reduction of metal precursors to form nanoparticles. It is therefore likely that MGF found abundantly in M. indica L., and HB extracts (HBE) can act as both reducing and stabilizing agent during the synthesis of AuNPs.…”

Section: Resultsmentioning

confidence: 99%

“…This further shows that C-H functional groups could also be involved in the reduction of gold ions [ 45 ]. Furthermore, the disappearance of peaks at 1488 and 1099 cm −1 corresponding to C-O-C and RCH 2 OH in MGF-AuNPs indicates the removal of the glucose unit from MGF [ 10 ]. Interestingly, these peaks are retained in HB-AuNPs indicating that the glucose units found in MGF might not be involved in the reduction and stabilization of HB-AuNPs.…”

Section: Resultsmentioning

confidence: 99%

“…These results indicate that the two AuNPs might be biocompatible when used in vivo. Independent studies have reported the biocompatibility and low cytotoxic effects of biogenic AuNPs; MGF-AuNPs (up to 100 µM) were shown to be non-toxic on non-cancerous breast MCF-10A cells following a 24 h treatment [ 10 ]. Another study also reported that AuNPs synthesized from Hibiscus sabdariffa extracts had very little toxic effect in non-cancerous 293 cells [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…The health benefits of MGF have prompted a rigorous research to find other sources of this valuable compound [ 4 , 5 ]. While the extracts from mango ( Mangifera indica L.) fruit peel [ 6 ], seeds, leaves [ 2 , 7 , 8 ], bark and roots [ 2 , 7 ] have been shown to contain this compound, MGF is also found abundantly in other plant species such as Salacia chinensis , Swertia chirata , Hypericum aucheri and Cyclopia intermedia [ 6 , 9 , 10 ]. The xanthones (MGF and isomangiferin) and flavanones (hesperitin and hesperidin) are the major components of C. intermedia extracts, and are thought to be responsible for most of its pharmacological effects, including anti-diabetic, anti-cancer, anti-obesity, antioxidant and antimicrobial activities [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Gold Nanoparticles Synthesized Using Extracts of Cyclopia intermedia, Commonly Known as Honeybush, Amplify the Cytotoxic Effects of Doxorubicin

et al. 2021

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Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported to have numerous biological activities, including anti-tumor activity. MGF and extracts that contain high concentrations of MGF, such as extracts from Mangifera indica L. or mango have been used to synthesize gold nanoparticles (AuNPs) using green nanotechnology. It has previously been shown that when AuNPs synthesized from M. indica L. extracts are used in combination with doxorubicin (DOX) and Ayurvedic medicine, the anti-tumor effects appear to be augmented. It has also been demonstrated that MGF used in combination with DOX resulted in enhanced anti-tumor effects. In this study, C. intermedia (HB) and MGF were used to synthesize HB-AuNPs and MGF-AuNPs, respectively. The physicochemical properties of the AuNPs were characterized by the UV-Visible Spectroscopy (UV-Vis), dynamic light scattering (DLS), Fourier transform infra-red spectroscopy (FTIR), X-ray diffraction spectroscopy (XRD) and high-resolution transmission electron microscopy (HR-TEM). The cytotoxicity of HB-AuNPs and MGF-AuNPs were assessed on human colon (Caco-2), prostate (PC-3) and glioblastoma (U87) cancer cells; as well as normal breast epithelial (MCF-12A) cells using the MTT assay. Both HB-AuNPs and MGF-AuNPs demonstrated relatively low cytotoxicity in these cells. However, when these nanoparticles were used in combination with DOX, the cytotoxicity of DOX was significantly augmented.

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Human Serum Albumin−Gold Nanoparticle Based Impedimetric Sensor for Sensitive Detection of miRNA‐200c

et al. 2020

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Here, human serum albumin conjugated gold nanoparticles (HSA−AuNPs) were synthesized by a simple route to develop an impedimetric sensor for miRNA‐200c detection based on a selective oligo‐hybridization process without any labeling. The synthetic DNA capture probe for miRNA‐200c was decorated onto the HSA−AuNPs modified pencil graphite electrodes. Impedimetric signals were monitored after the hybridization process between the DNA probe and target miRNA‐200c. HSA−AuNPs adsorption time, incubation time of the capture probe and hybridization time‐temperature were optimized. The proposed miRNA‐200c biosensor demonstrated proper sensitivity and selectivity, low detection limit (1.13 fM), good reproducibility and simple direct detection of miRNA‐200c in serum.

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Preparation and mechanistic aspect of natural xanthone functionalized gold nanoparticle

Cited by 24 publications

References 43 publications

Mangiferin-Loaded Polymeric Nanoparticles: Optical Characterization, Effect of Anti-topoisomerase I, and Cytotoxicity

Mangiferin-Loaded Polymeric Nanoparticles: Optical Characterization, Effect of Anti-topoisomerase I, and Cytotoxicity

Gold Nanoparticles Synthesized Using Extracts of Cyclopia intermedia, Commonly Known as Honeybush, Amplify the Cytotoxic Effects of Doxorubicin

Human Serum Albumin−Gold Nanoparticle Based Impedimetric Sensor for Sensitive Detection of miRNA‐200c

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