Preparation and investigation of the tenoxicam/β-cyclodextrin complex

Şenel, Sevda; Çakoĝlu, Önder; Şumnu, Murat; Duchêne, Dominique; Hıncal, A. A.

doi:10.1007/bf01029665

Cited by 11 publications

(5 citation statements)

References 12 publications

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“…The average value, A h , for the three experi- ments is 1.0 ( 0.05, as usually found for most CD:guest systems. 20-22, [29][30][31][32][33][34] Conductivity StudysIn Figures 3 and 4, the values of the molar conductance (Λ ) 1000κ/[NaSA]) of the drug solutions are plotted as a function of sodium salicylate concentration (at various constant [DIMEB]) and as a function of DIMEB concentration (at various constant [NaSA]), respectively. Similar plots have been obtained for the system -CD + NaSA.…”

Section: Speed Of Sound Studysinmentioning

confidence: 99%

“…Several features regarding CD/drug/water systems need to be remarked upon in order to choose the most suitable model: (i) Most drug molecules are known to form 1:1 inclusion complexes with CD's. 5,6,[30][31][32][33][34] This fact, together with the well-known cavity size of the -CD and derivatives [35][36][37] and the small size of the SAmolecule, leads us to assume that complexes such as CD 2 :SAor CD: (SA -) 2 or those with even higher stoichiometries are not expected. Furthermore, this fact has been confirmed in this work through speed of sound and conductivity measurements.…”

Section: Figure 4splotmentioning

confidence: 99%

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Binding of Sodium Salicylate by β-Cyclodextrin or 2,6-Di-O-methyl-β-cyclodextrin in Aqueous Solution

Junquera

Peña

Aicart

1998

Journal of Pharmaceutical Sciences

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Speed of sound and conductivity experiments have been done at 298.15 K to study the encapsulation process of sodium salicylate (NaSA) by beta-cyclodextrin (beta-CD) and 2,6-di-O-methyl-beta-cyclodextrin (DIMEB) in aqueous solutions. Since the concentration of the salicyclic form (HSA), coming from the hydrolysis of SA-, is negligible at biological pH, the binding process studied in this work is that of the SA- species. The stoichiometries of the complexes DIMEB: SA- and beta-CD:SA- have been found to be 1:1, as usually determined for most CD:drug complexes. Their association constants and their ionic molar conductivities at infinite dilution have been obtained by fitting the experimental conductivity data with a nonlinear regression method (NLR). For that purpose, a model based on that of Gelb and co-workers has been used. From the values of K beta-CD:SA- = (105 +/- 15)M-1 and KDIMEB:SA- = (140 +/- 20)M-1 obtained, the bioavailability of the salicylate drug in the complexed form has been discussed.

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Section: Speed Of Sound Studysinmentioning

confidence: 99%

Section: Figure 4splotmentioning

confidence: 99%

Binding of Sodium Salicylate by β-Cyclodextrin or 2,6-Di-O-methyl-β-cyclodextrin in Aqueous Solution

Junquera

Peña

Aicart

1998

Journal of Pharmaceutical Sciences

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“…33 Stability constant of LXM-b-CD inclusion complex was higher than that with either g-CD or a-CD (values were 10.959, 6.400 and 3.700 M À1 for b-CD, g-CD and a-CD, respectively). Stability constants of different oxicam derivatives were of lower values compared to nding by other investigators [36][37][38] which may be attributed to the high pH value of the complexation medium used (5 Â 10 À2 mol L À1 NaOH). 34,35 The stability constants for different OXM derivatives with b-CDs (III-V), assuming a 1 : 1 stoichiometry are listed in Table 1.…”

Section: Characterization Of Lxm/b-cds Inclusion Complexesmentioning

confidence: 61%

“…Phase solubility experiments at 25 C showed an increase of the drug solubility in a linear form as a function of CDs concentration indicating formation of a soluble complex of the A L type. Stability constants of different oxicam derivatives were of lower values compared to nding by other investigators [36][37][38] which may be attributed to the high pH value of the complexation medium used (5 Â 10 À2 mol L À1 NaOH). 36 Moreover, the apparent stability constants of the four investigated oxicam derivatives with b-CDs (III-V) lie in the following order: 2,3,…”

Section: Characterization Of Lxm/b-cds Inclusion Complexesmentioning

confidence: 64%

Novel screen printed potentiometric sensors for the determination of oxicams

et al. 2015

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The construction and performance characteristics of new sensitive and selective sensors based on functionalized multi-walled carbon nanotubes/b-cyclodextrin nanocomposite (FMWCNTs/b-CD) was demonstrated for potentiometric determination of different anti-inflammatory agents including lornoxicam, meloxicam, piroxicam and tenoxicam. Screen printed sensors (SPEs) modified with FMWCNTs/b-CD composite, hyamine (Hy) and 2-fluorophenyl 2-nitrophenyl ether (f-PNPE) showed proper electroanalytical performances with a Nernstian compliance range between 61.2 and 52.6 mV decade À1 activity and a detection limit of 6.0 Â 10 À7 mol L À1 for different oxicam derivatives. Modification with carbon nanotube composite as sensing material remarkably improved the potential stability and lifetime of the fabricated sensors. The proposed sensors offer a simple analytical tool for determination of different oxicam derivatives in their pharmaceutical formulations under batch and flow injection analysis (FIA) conditions.

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“…Several authors have used SEM, TGA, SDC, UV and FTIR spectroscopy experiments, to show that it is possible to form inclusion complexes between the Tenox and a, b and c cyclodextrins in the solid phase [3,6]. Notwithstanding, the assessment of the inclusion constant between the Tenox and the cyclodextrins in aqueous media have been little studied.…”

Section: Introductionmentioning

confidence: 98%