Preparation and investigation of hydrolyzed polyacrylonitrile as a preliminary biomedical hydrogel

Park, Ji Hoon; Tai, Guo Zhe; Lee, Bo Keun; Park, Seung Hun; Jang, Ja Yong; Lee, Jungsoo; Kim, Jae Ho; Jang, Ju Woong; Kim, Moon Suk

doi:10.1186/s40824-015-0043-1

Cited by 9 publications

(3 citation statements)

References 22 publications

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“…Currently, primary peripheral blood (PB), primary cord blood (CB), immortalized oncogenic immune cell lines (eg.THP-1, NK-92 cells), and iPSCs are the main sources for in vitro differentiation of immune cells [5]. In comparison, PB and CB-derived immune cells have limitations due to their variability in functional competence and expansion potential.…”

Section: Introductionmentioning

confidence: 99%

Integrating single-cell genomics for specific guidance of iPSCs fate commitment in adoptive cell therapy

Li,

2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

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Induced pluripotent stem cells (iPSCs) have immense potential for regenerative medicine, particularly as a main source of adoptive immune cells. However, due to the variation of genetic and epigenetic factors on the differentiation of iPSCs cells, the final desired outcome is often impure. Therefore, fully harnessing the capabilities of iPSCs requires precise control over their fate commitment, ensuring the generation of desired cell lineages with functional properties. In recent years, the integration of single-cell genomics has emerged as a powerful approach for guiding iPSCs fate commitment with unparalleled resolution and specificity. In this paper, we aim to discuss the methodologies and technologies utilized in single-cell genomics, specifically focusing on single-cell RNA sequencing, T cell receptor sequencing, and advanced computational analysis methods. We further explore how these techniques have been applied to uncover the genetic and epigenetic changes involved in iPSCs fate commitment, identify important regulators, and track lineage trajectories at the single-cell level. Additionally, we also provide a concise pipeline to guide iPSCs differentiation by integrating single-cell genomic approaches.

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Section: Introductionmentioning

confidence: 99%

Integrating single-cell genomics for specific guidance of iPSCs fate commitment in adoptive cell therapy

Li,

2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

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“…Moreover, PAN is the most used polymer in SBS due to its excellent mechanical properties [39][40][41][42] and exceptional chemical stability [39]. PAN has become a focus of significant research for a long time, not only owing to its good mechanical and fiber-forming properties for textiles and carbon fibers, but also as hydrogels [43] and membrane surfaces [44] for biomedical applications [45]. Thus, it is ideal to be used as a co-precursor for SBS of pectin.…”

Section: Introductionmentioning

confidence: 99%

Preparation of mango peel-waste pectin-based nanofibers by solution blow spinning (SBS)

Martin¹,

Flores²,

Siacor³

et al. 2022

Nanotechnology

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An essential prerequisite for successful solution blow spinning (SBS) is the presence of effective molecular entanglements of polymers in the solution. However, the fabrication of biopolymer fibers is not as straightforward as synthetic polymers. Particularly for biopolymers such as pectin, molecular entanglements are essential but insufficient for successful spinning through the SBS production method. Such a challenge is due to the biopolymer's complex nature. However, incorporating an easily spinnable polymer precursor, such as polyacrylonitrile (PAN), to pectin effectively enabled the production of fibers from the SBS process. In this process, PAN-assisted pectin nanofibers are produced with average diameters ranging from 410.75 ± 3.73 nm to 477.09 ± 6.60 nm using a feed flow rate of 5 mL/hr, air pressure of 3 bars, syringe tip to collector distance at 30 cm, and spinning time of 10 minutes. PAN in DMSO solvent at different volume ratios (i.e., 35% – 55% v/v) was critical in assisting pectin to produce nanofibers. The addition of a high molecular weight polymer, PAN, to pectin also improved the viscoelasticity of the solution, eventually contributing to its successful SBS process. Furthermore, the composite SBS-spun fibers obtained suggest that its formation is concentration-dependent.

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“…13 PAN fibers have a high melting point (317 °C-322 °C) and a high degree of molecular orientation as well as non˗toxic and ecofriendly. 14 Due to these features, it is used as a yarn in textile industry, as a membrane in water purification 15,16 and biomedical aplications, 17,18 a separator in Li˗ion batteries, 19,20 a carbon precursor in supercapacitors, 21,22 and a matrix in flexible electronics 23,24 and, electrochromic applications. 25,26 Considering these wide˗scale application areas of PAN, in this study, it was investigated whether PAN could be used as an interfacial layer in Schottky type structures.…”

mentioning

confidence: 99%

Dielectric Characterization of Al/PAN/n˗Si/Al Structure as a Function of Frequency and Voltage

Turan¹

2022

ECS J. Solid State Sci. Technol.

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In this study, the voltage and frequency dependencies of dielectric properties of Al/Polyacrylonitrile (PAN)/n˗Si/Al metal/polymer/semiconductor (MPS) were analyzed. To determine the dielectric characteristics, capacitance˗voltage (C–V) and conductance˗voltage (G–V) of Al/PAN/n˗Si/Al were measured depending on the frequency and bias voltage ranges in 10 kHz–1 MHz and ±5 V at room temperature. Using the C–V and G–V measurements, dielectric parameters; ε′, ε″, and tan δ, M′and M″, were evaluated depending on voltage and frequency. As the frequency increased, ε′ and ε″ decreased, while peaks related to the relaxation mechanism were observed in M″ and tan δ. The ε′ values at 10 kHz and 1 MHz are 15.2 and 4.58 for 1 V, respectively. Relaxation times were calculated using the peaks in the M″˗f plot and it was seen that the relaxation time decreased as the bias voltage increased. Relaxation mechanism is related to non˗Debye relaxation in PAN/n–Si structure. The existence of relaxation peaks in M″ curves showed that the studied material is an ionic conductor.

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Preparation and investigation of hydrolyzed polyacrylonitrile as a preliminary biomedical hydrogel

Cited by 9 publications

References 22 publications

Integrating single-cell genomics for specific guidance of iPSCs fate commitment in adoptive cell therapy

Integrating single-cell genomics for specific guidance of iPSCs fate commitment in adoptive cell therapy

Preparation of mango peel-waste pectin-based nanofibers by solution blow spinning (SBS)

Dielectric Characterization of Al/PAN/n˗Si/Al Structure as a Function of Frequency and Voltage

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