Preparation and in vitro evaluation of the antiviral activity of the Acyclovir complex of a β-cyclodextrin/poly(amidoamine) copolymer

Bencini, Marco; Ranucci, Elisabetta; Ferruti, Paolo; Trotta, Francesco; Donalisio, Manuela; Cornaglia, Maura; Lembo, David; Cavalli, Roberta

doi:10.1016/j.jconrel.2007.11.004

Cited by 42 publications

(22 citation statements)

References 19 publications

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“…[13–16] β-CD might be the best natural β-CD due to its drug complexation and availability in pure form. [17] Meanwhile, its low cost and simple synthesis also have expanded its application.…”

Section: Introductionmentioning

confidence: 99%

Effect of β-cyclodextrin complexation on solubility and enzymatic hydrolysis rate of icariin

et al. 2013

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Objective:The aim of this work was to investigate the effect of β-cyclodextrin complexation on the solubility and hydrolysis rate of icariin.Material and Methods:The inclusion complex of icariin at the molar ratio of 1:1 was obtained by the dropping method and was characterized by differential scanning calorimetry. The solubility of icariin complex in water at 37°C was 36 times greater than that of free icariin. Enzymatic hydrolysis conditions were tested for the bioconversion of icariin by mono-factor experimental design.Methods:The inclusion complex of icariin at the molar ratio of 1:1 was obtained by the dropping method and was characterized by differential scanning calorimetry. The solubility of icariin complex in water at 37°C was 36 times greater than that of free icariin. Enzymatic hydrolysis conditions were tested for the bioconversion of icariin by mono-factor experimental design.Results:The enzymatic hydrolysis experiment showed that icariin can be transformed into baohuoside I. The optimum conditions determined were as follows: pH 5.0, 50°C, the ratio of cellulase/substrate (0.6), the concentration of icariin 20 mg/ml, and reaction time 12 h. Under these enzymatic conditions, 98.2% transforming rate of baohuoside I from icariin in inclusion complexes was obtained.ConclusionThe aqueous solubility and enzymatic hydrolysis rate of icariin were improved owing to the inclusion complexation.

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Section: Introductionmentioning

confidence: 99%

Effect of β-cyclodextrin complexation on solubility and enzymatic hydrolysis rate of icariin

et al. 2013

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“…Rifampicin Oral E. coli, S. aureus ND [44] HPβ-CD Solubility and stability Ciprofloxacin Ocular ND ND [33] γ-CD Stability Dicloxacillin ND ND ND [34] β-CD Stability Erythromycin Parenteral S. aureus ND [30] β-, γ-CD Stability Amoxicillin Oral ND ND [35] β-CD Stability Doxycycline ND E. coli ND [38] HPβ-CD Stability Doxycycline Ocular ND ND [24] HPβ-CD Stability Doxycycline Ocular E. coli, P. aeruginosa, S. aureus ND [39] HPβ-CD Stability Ciprofloxacin Ocular P. aeruginosa, S. aureus ND [32] β-CD Controlled release TSC Ocular P. aeruginosa, S. aureus ND [48] Viral β-CD Solubility Acyclovir Ocular ND ND [62] HPβ-CD Solubility Saquinavir Oral ND ND [56] HPβ-CD Solubility Saquinavir Vaginal HIV-infected MT-4 cells ND [61] β-, HPβ-, Mβ-CD Solubility UC781 Vaginal ND ND [60] β-CD Solubility Acyclovir ND Two clinical isolates of HSV-1 ND [63] HPβ-, HPγ-, Mβ-CD Solubility and stability TSC ND ND ND [6] HPβ-CD Solubility and stability TSC ND Hepatitis C virus ND [107] HPβ-CD Solubility and stability Ganciclovir Ocular ND Rabbit (ex vivo assay) [51] HBenβ-CD Solubility and bioavailability Saquinavir Oral ND Rat [55] Mβ-CD Solubility and bioavailability Saquinavir Oral ND Rat …”

Section: Application Of Cyclodextrins In Infectious Diseasesmentioning

confidence: 99%

“…In this context, Bencini et al produced a synthetic, biocompatible, biodegradable, nontoxic and water-soluble derivative based on β-CD and poly(amidoamine) that was used to complex ACV [63]. This ACV/complex was evaluated in vitro against two clinical isolates of herpes simplex virus revealing a higher antiviral activity than the free drug [63]. These findings are an additional example of the versatility that can be achieved with CDs in drug delivery.…”

Section: Figure 3 Stability Of Natamycin and Natamycin/γ-cd Inclusiomentioning

confidence: 99%

Cyclodextrin Complexes for Treatment Improvement in Infectious Diseases

Imperiale

Sosnik

2015

Nanomedicine (Lond.)

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Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented.

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“…Other PAA derivatives, such as branched polymers with arginine, maintain the cell internalization capacity of the amino acid, but having increased biocompatibility than argininerich cell penetrating peptides [66]. PAAs have been used as carriers for the antiviral compound Acyclovir [67], where in vitro experiments showed that polymer conjugation of the drug increased its activity. More recent results [68,69], indicate that agmatine-containing PAAs possess antiviral activity which is not a mere consequence of cytotoxicity.…”

Section: Paa Applications In Drug Deliverymentioning

confidence: 99%

Polyamidoamine Nanoparticles as Nanocarriers for the Drug Delivery to Malaria Parasite Stages in the Mosquito Vector

Urbán

Ranucci

Fernàndez‐Busquets

2015

Nanomedicine (Lond.)

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SummaryMalaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium spp. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial compounds exclusively to Plasmodium-infected cells, thus increasing drug efficacy and minimizing the induction of resistance to newly developed therapeutic agents. Poly(amidoamine) (PAA)-derived nanovectors combine into a single chemical structure drug encapsulating capacity, antimalarial activity, low unspecific toxicity, specific targeting to Plasmodium, optimal in vivo activity, and affordable synthesis cost. After having shown their efficacy in targeting drugs to intraerythrocytic parasites, now PAAs face the challenge of spearheading a new generation of nanocarriers aiming at the malaria parasite stages in the mosquito vector.

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Preparation and in vitro evaluation of the antiviral activity of the Acyclovir complex of a β-cyclodextrin/poly(amidoamine) copolymer

Cited by 42 publications

References 19 publications

Effect of β-cyclodextrin complexation on solubility and enzymatic hydrolysis rate of icariin

Effect of β-cyclodextrin complexation on solubility and enzymatic hydrolysis rate of icariin

Cyclodextrin Complexes for Treatment Improvement in Infectious Diseases

Polyamidoamine Nanoparticles as Nanocarriers for the Drug Delivery to Malaria Parasite Stages in the Mosquito Vector

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