Preparation and in Vitro Bioactivity of Micron-sized Bioactive Glass Particles Using Spray Drying Method

Abstract

In recent years, bioactive glasses (BGs) have attracted enormous attention with their superior bioactivity, non-toxicity and degradability. Owing to their properties, they have been applied in various biological applications. In the present work, we demonstrated that micron-sized BGs can be prepared with a spray drying method. This technique offers the advantages of low contamination and the ability of mass production, in contrast to the two major synthetic methods, conventional glass-melting and sol-gel, previously used for preparation of BGs. Characterizations of phase composition, morphology and specific surface area of spray dried BG powders were carried out and bioactivity was examined in vitro with respect to the ability to form a hydroxyapatite layer on the surface of the particles after they were immersed in simulated body fluid.

Correlation of Morphology and In-Vitro Degradation Behavior of Spray Pyrolyzed Bioactive Glasses

“…Next, the spray drying method gives high control over shape and morphology through a fast kinetic process. However, when the process is performed by spraying inflammable solvents, both safety and economic concerns will rise in view of an effective process [14,15]. Instead, the SP method offers the following merits: easy to operate, economical, continuous processing, and short process time [16,17].…”

Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

“…The BG used in this study was 58S with a melting point of 1400 °C, which was quite close to that of 1650 °C of Ti-6Al-4V. The 58S BG comprised 60 mol% SiO 2 , 36 mol% CaO, and 4 mol% P 2 O 5 [ 39 ]. Our research findings indicated that 0.25% was the most appropriate concentration of BG for the additive manufacturing process, with the best mechanical properties.…”

“…Based on the authors’ earlier study, the BG composition of 58S exhibited a higher growth rate of HA and better bioactivity [ 39 ]. Therefore, we were motivated to conduct further extensive research on bone incorporation and osseointegration performance of pedicle screw implants comprising Ti-6Al-4V doped with BG composite material with optimal shape design of the healing chamber through in vivo studies.…”

Mesoporous Properties of Bioactive Glass Synthesized by Spray Pyrolysis with Various Polyethylene Glycol and Acid Additions

“…The fabrication process of BG includes glass melting, sol-gel, and spray pyrolysis processes [ 12 ]. Glass melting process is the conventional process that requires high temperatures (1250–1400 °C) and the product may contain impurities and further result in low bioactivity of synthetic glass [ 13 , 14 ]. Sol-gel process is introduced to BG synthesis in 1991 [ 15 ] and became a popular alternative method because of the relatively lower heat treatment temperature (600–800 °C) compared to the glass melting processes, and ease of control of textural properties [ 16 , 17 ].…”