Mesoporous Properties of Bioactive Glass Synthesized by Spray Pyrolysis with Various Polyethylene Glycol and Acid Additions

Abstract

Mesoporous bioactive glass (MBG) has a high specific surface area, promoting the reaction area, thereby improving the bioactivity; thus, MBG is currently gaining popularity in the biomaterial field. Spray pyrolysis (SP) is a one-pot process that has the advantages of shorter process time and better particle bioactivity, therefore, MBG was prepared by SP process with various polyethylene glycol (PEG, molecular weight ranged from 2000–12,000) and acid (HCl and CH3COOH) additions. In vitro bioactivity and mesoporous properties of the so-obtained MBG were investigated. The experimental results showed that all the MBG exhibited amorphous and mesoporous structure. Increasing the molecular weight of PEG can improve the mesoporous structure and bioactivity of MBG. Whereas optimized MBG was prepared with suitable concentration of PEG and CH3COOH. In the present work, MBG synthesized via spray pyrolysis by adding 5 g of PEG with a molecular weight of 12,000 and 50 mL of CH3COOH exhibited the best in vitro bioactivity and mesoporous structure.

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

“…There are multiple approaches to synthesize MBG NPs, which allow modulating not only the inherent properties of MBGs but also their size, morphology and structure, as reported elsewhere [65][66][67][68][69][70]. In this sense, the possibility to obtain the core-shell structure of MBG may be expanded to the biomedical field, such as tissue ingrowth, vascularization, nutrient delivery, etc., as it has been described elsewhere [59,71].…”

“…Normally, biomaterials exhibiting nanodimensions show higher surface energy and reactivity than micrometric ones [56]. Actually, in the last decade, there has been growing demand of mesoporous bioactive glass nanoparticles (MBG NPs), which can be fabricated by using different synthesis methods such sol-gel [57] or spray pyrolysis [58,59]. Their diminished size allows MBG NPs to be integrated into a wide range of biomedical devices such as cements [60], coatings [61], composite materials [62], scaffolds [62,63] and drug delivery systems [64], making them ideal nanoplatforms for bone tissue regeneration [65,66].…”

Cerium Containing Bioactive Glasses: A Review

“…Since the 1990s, the interest toward the sol–gel synthesis has increased; , in 1991 some BGs in ternary SiO 2 –CaO–P 2 O 5 systems were synthesized by the sol–gel method. The main steps involved are preparation of sol, casting, gelation, aging, drying, and thermal stabilization. , The addition of an acid catalyst (acid water-based solutions, such as HCl, HNO 3 , and CH 3 COOH) during the sol–gel process is necessary in order to obtain a 3D reticulated structure. With respect to MQGs, SGGs are purer, more homogeneous in composition, and more porous and have higher specific surface area (SSA, usually ∼100–650 m 2 /g).…”